1,721,067 research outputs found
Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones.
No full textAssignment of the mouse Gdnfra, the homologue of a new human HSCR candidate gene, to the telomeric region of mouse Chromosome 19.
No full textA top-down linguistic approach to the analysis of genomic sequences: The metabotropic glutamate receptors 1 and 5 in human and in mouse as a case study.
No full textHOX11L1, a gene involved in the Peripheral Nervous System development, maps to human chromosome 2p12-p13.1 and mouse chromosome 6C3-D1.
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Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer.
No full textIt has been suggested that common fragile sites (cFSs) are related to cancer development. This appears to be the case for FRA3B and FRA16D, localized in two tumor-suppressor genes (FHIT and WWOX, respectively) that are altered by deletions or
loss of heterozygosity (LOH) in many cancers. The features responsible for fragility have not yet been identified. Furthermore,
it is still unclear whether instability at these regions causes chance deletions and loss of function of the associated genes, or
whether the gene function itself is related to the appearance of fragility. In this study, we analyzed cFS expression in lymphocytes
from 20 healthy or thyroid cancer–affected subjects exposed to radiation after the Chernobyl accident. The same cells
were examined for apoptosis, a principal function of both the FHIT and WWOX genes. Exceptionally elevated chromosome fragility
was observed, particularly in cancer patients, affecting FRA3B, FRA16D, and a cluster of less highly expressed cFSs; levels
of chromosome fragility were found to be correlated among these cFSs. Interestingly, most expressed cFSs were sites of LOH
reported for thyroid tumors; moreover, cells with the highest fragility also had a reduced ability to undergo apoptosis. These
findings reveal previously unknown genetic interactions affecting fragile loci, suggestive of a shared function inside mitotic cells.
Attenuation of checkpoint control and apoptosis resistance seem to be the cell phenotypes associated with unusual chromosome
fragility. We propose that breakage at specific cFS could derive from early epigenetic events at loci involved in radiation carcinogenesis
Neuronal defects in genotyped dominant megacolon (Dom) mouse embryos, a model for Hirschsprung disease.
No full textThe HIV-1 viral protein TAT modulates glutamate and GABA exocytosis from human and mouse neocortical nerve endings
No full textTotal colonic aganglionosis associated with an interstitial deletion of the long arm of chromosome 10. Molecular characterization of the region and family studies
No full textGroup I metabotropic glutamate receptors in ALS: knocking-down mGlu1 receptors ameliorates survival and disease progression in SOD1/G93A mice.
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