87 research outputs found
Time spans of soil formation and late Pleistocene-Holocene climate changes in the Somma-Vesuvius volcano area, southern Italy
No full textMultidisciplinary study of Holocene archaeological soils in an upland Mediterranean site: Natural versus anthropogenic environmental changes at Cecita Lake, Calabria, Italy
No full textThis paper highlights results of a multidisciplinary and multi-analytical study of Holocene archaeological soils around Cecita Lake (Sila massif, Calabria, southern Italy), which represents a typical upland Mediterranean environment. It is focused on assessment of climatic and environmental changes that took place since late Neolithic to Roman times, trying to discriminate natural from anthropogenic signals. Based on an integration of archaeological, geomorphological, stratigraphic, pedological, volcanological and soil charcoal (pedoanthracological) data, the following paleoclimatic/environmental reconstruction is proposed: a warm and humid, seasonally contrasted climate, with an overall geomorphological stability suited for soil development, characterized the late prehistoric environment (Holocene climatic optimum), dominated by a widespread oak forest. The main pedogenetic processes consisted in organic matter accumulation, clay illuviation, phyllosilicate and short-range order mineral neogenesis from weathering of granite and volcanic ash, sourced from late Pleistocene-Holocene eruptions of the Aeolian Islands. One or more mid-Holocene episodes of climate deterioration towards drier conditions (indicated by a decrease of clay translocation processes and possible irreversible dehydration of poorly-crystalline aluminosilicates into phyllosilicate clay minerals) promoted intense land degradation. This was in turn enhanced by increasing human activities for settlement and resource exploitation (among which deforestation and ploughing for agriculture), which led to a shift of the vegetation cover towards a dominant pine forest between 3kaBP and the Roman epoch. Humid and possibly cooler climatic conditions during the late Holocene are indicated by the decrease of clay illuviation, coupled with short-range order components prevailing over phyllosilicate clays during Roman soil formation
Alcune osservazioni accanto agli alimenta Italiae
No full textAfter reconstructing the framework of the historical problems evoked by the book of Rossella Laurendi, the author proposes some reflection over the well-known book of evergetism by Paul Veyne concerning economic history,ancient demography and imperial coinag
Malevic
No full textL'A. espone il percorso dell'artista russo dalla sua formazione simbolista fino alla produzione tarda, insieme ai suoi scritti. Si dà particolare importanza alle relazioni con gli scritti teosofici, la cultura occultista e la meditazione orientale. The Author examines the russian artist from his symbolistic education until the last production, and his writings also. Particularly important are the relationships with theosophical writings, occultist culture and Eastern meditation. Dossier allegato alla rivista "Art e Dossier", maggio 200
Arte contemporanea: le avanguardie storiche
No full textL'A. prende in esame i fauves, il cubismo, l'orfismo, l'espressionismo della "Brücke" e del "Blaue Reiter", il futurismo, il suprematismo, il neoplasticismo e il costruttivismo russo; nonché concezioni architettoniche tra "Art Nouveau" e "Bauhaus". In ogni capitolo si dedica particolare attenzione alle metodologie critiche dall'inizio del secolo ad oggi. The Author examines Fauvism, Cubism, Orfhism, Expressionism of "Die Brücke" and "Der Blaue Reiter", Futurism, Suprematism, Neoplasticism, russian Konstruktivism; and concepts of architecture in the period from "Art Nouveau" to "Bauhaus". In every chapter are particularly focused the critical-methodological approaches from beginning of the XX century up to now
Severini e Denis
No full textL'A. prende in esame i controversi rapporti tra i due artisti, nel primo decennio del secolo e, più tardi, nella produzione di carattere religioso. Severini risulta influenzato da Denis più di quanto sostenga negli scritti teorici. The Author examines the controversial relationships between the two artists, in the first decade of the century and later on, in their religious production. Severini appears influenced by Denis more than he declares in his theoretic writings
La lingua di Shakespeare e l'ingiuria del tempo: tradurre Troilo e Cressida
No full textIl saggio prende in esame la nuova traduzione italiana di Troilo e Cressida (W. Shakespeare) per Feltrinelli, pubblicata dall'autrice stessa, evidenziando le criticità che nascono nella resa contemporanea di un testo 'early modern', adottando una prospettiva di indagine storico-linguistica, e riflettendo su punti di contatto e divergenza tra traduzione per 'la pagina' e per 'la scena'.The essay deals retrospectively with the production of a new translation of Shakespeare's Troilus and Cressida into contemporary Italian (published by the author with Feltrinelli in 2015). Literary translation problems and open questions about the differences between translation 'for the page' and 'for the stage' are explored within a historical-linguistic perspective
Archiviare il contemporaneo. Lo Spazio di Via Lazzaro Palazzi come paradigma
No full textThe archive is an inclusive and never static memory device. Thus, it is necessary to take care of it, carefully considering the specificity of collectibles, reviewing and updating continuously the criteria and methods of selection, cataloging and conservation. Only through this assumption of responsibility, which also involves raising awareness of public attention, the archive
redefines itself in the present, and in anticipation of the future, as a
place of (mnestic, political, social, cultural) possibility. This article presents how the project of the enhancement of the Archive of the artist-run space Lo Spazio di Via Lazzaro Palazzi (Milan, 1989-1992) at the Museo del Novecento di Milano was created collectively -- as a collaboration between the artists, the museum and the scientific coordinators of the project (among which the author) -- with this awareness. The wish is that the constitution, donation
and enhancement of this specific Archive will represent a
paradigm for the preservation, accessibility and (public) knowledge of contemporary artist archives
Rationale and protocol of MetNET-2 trial: Lanreotide Autogel plus metformin in advanced gastrointestinal or lung neuroendocrine tumors
No full textMetformin (MET) has recently emerged as a potentially active agent in cancer prevention and treatment. MET is thought to exert its antitumor effects either via modification of systemic metabolism or through cell-autonomous effects (e.g., activation of AMPK and inhibition of the mTOR pathway). Preliminary findings of the PRIME-NET study suggest that the addition of MET to treatment with everolimus (EVE) and/or somatostatin analogs (SSAs) can provide clinical benefit in diabetic neuroendocrine tumor (NET) patients. In light of this and other retrospective evidence of MET’s anticancer activity in NETs, prospective studies are needed.
A pilot, single-arm, open-label, prospective study (MetNET-2 trial, NCT02823691) was designed to evaluate the safety of MET in combination with lanreotide in well-differentiated gastrointestinal (WD GI) and lung NETs
Target therapies plus somatostatin analogues in NETs: a network meta-analysis
No full textAlthough combination therapy is not recommended in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs), this strategy is widely used in clinical practice. This network meta-analysis of randomized trials evaluates targeted therapies and somatostatin analogues in GEP advanced NETs, either alone or in combination, comparing the efficacy of different single or combined treatment strategies in terms of progression-free survival (PFS). Interventions were grouped as analogues, everolimus, everolimus plus SSAs, sunitinib and placebo. In a secondary analysis, we also assessed the efficacy of individual specific pharmacological treatments versus placebo or each other. From 83 studies identified, 8 randomized controlled trials were selected, with a total of 1849 patients with either functioning or non-functioning NETs. The analysis confirmed the superiority of all treatments over placebo (HR ranging from 0.34, 95% CI: 0.24-0.37 with the combination of everolimus plus SSAs to 0.42, 0.31-0.57 with the analogues; moderate quality of evidence). On ranking analysis, the combination of everolimus plus SSA (P score=0.86) and then everolimus alone (P score=0.65) ranked highest in increasing PFS. On comparative evaluation of different interventions, pasireotide (P score=0.96) and everolimus+octreotide (P score=0.82) ranked as the best pharmacological treatment options. Our findings support the use of combination therapy in the treatment of functioning and non-functioning GEP NETs. The role of pasireotide should be explored in selected subgroups of patients. Last, the combination of everolimus and octreotide appears promising and should be more widely considered in clinical practice
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