2,010 research outputs found
Book Discussion : PJ Powers
No full textThe UJ Campus Health Services and the Student Affairs Division in partnership with the UJ Library invite you to meet PJ Powers (Thandeka) the co-author of the book HERE I AM About the book: Here I Am, written with Marianne Thamm, is an intimate and hilarious account of the life and times of one of this country’s most recognisable and enduring performers. From the dizzying heights of international stardom to the dark depths of her struggle with alcohol, this is a must-read to explore the heady mix of politics and music of the time. More than just a story about the personal journey of one of South Africa’s most beloved music icons, this extraordinary memoir of PJ Powers – or Thandeka, as she was affectionately renamed by Soweto crowds – is set against the turbulent backdrop of South Africa’s recent political history. It features a gallery of political leaders and international celebrities, including the likes of Nelson Mandela, Graça Machel, Chris Hani, Joaquim Chissano, Queen Elizabeth II, Brenda Fassie, Sharon Stone and Robert De Niro. Facilitator: Prof Alban Burke, Director – PsyCad, University of Johannesburg PJ Powers will also perform a few songs on the day. Date: 27 August 2015 Time: 16:30 for 17:00 Venue: Auditorium (6th Floor), APK Library, University of Johannesburg (corner Kingsway and University Road, Auckland Park) RSVP: By Wednesday, 26 August 2015 to Theodorah Modise on [email protected] / 011 559 226
Book Discussion : PJ Powers
No full textThe UJ Campus Health Services and the Student Affairs Division in partnership with the UJ Library invite you to meet PJ Powers (Thandeka) the co-author of the book HERE I AM About the book: Here I Am, written with Marianne Thamm, is an intimate and hilarious account of the life and times of one of this country’s most recognisable and enduring performers. From the dizzying heights of international stardom to the dark depths of her struggle with alcohol, this is a must-read to explore the heady mix of politics and music of the time. More than just a story about the personal journey of one of South Africa’s most beloved music icons, this extraordinary memoir of PJ Powers – or Thandeka, as she was affectionately renamed by Soweto crowds – is set against the turbulent backdrop of South Africa’s recent political history. It features a gallery of political leaders and international celebrities, including the likes of Nelson Mandela, Graça Machel, Chris Hani, Joaquim Chissano, Queen Elizabeth II, Brenda Fassie, Sharon Stone and Robert De Niro. Facilitator: Prof Alban Burke, Director – PsyCad, University of Johannesburg PJ Powers will also perform a few songs on the day. Date: 27 August 2015 Time: 16:30 for 17:00 Venue: Auditorium (6th Floor), APK Library, University of Johannesburg (corner Kingsway and University Road, Auckland Park) RSVP: By Wednesday, 26 August 2015 to Theodorah Modise on [email protected] / 011 559 226
Technologically mediated learning: The future of training in Australia
No full textHosie, PJ ORCiD: 0000-0003-2585-024XFollowing a review of the economic imperatives currently facing Australia,
the future directions training will take are examined. Related training issues are considered; such as multiskilling, on-the-job training and legal issues. The author predicts that technologically mediated learning (TML),
especially interactive multimedia, will gain ascendancy as the predominant mode of delivery for training
A 0.7-V 0.43-pJ/cycle Wakeup Timer based on a Bang-bang Digital-Intensive frequency-Locked-Loop for IoT Applications
No full textA 40-nm CMOS wakeup timer employing a bang-bang digital-intensive frequency-locked loop for Internet-of-Things applications is presented. A self-biased ΣΔ digitally controlled oscillator (DCO) is locked to an RC time constant via a single-bit chopped comparator and a digital loop filter. Such highly digitized architecture fully exploits the advantages of advanced CMOS processes, thus enabling operation down to 0.7 V and a small area (0.07 mm 2 ). Most circuitry operates at 32× lower frequency than the DCO in order to reduce the total power consumption down to 181 nW. High frequency accuracy and a 10× enhancement of long-term stability is achieved by the adoption of chopping to reduce the effect of comparator offset and 1/f noise and by the use of ΣΔ modulation to improve the DCO resolution. The proposed timer achieves the best energy efficiency (0.43 pJ/cycle at 417 kHz) over prior art while keeping excellent on-par long-term stability (Allan deviation floor <;20 ppm) and temperature stability (106 ppm/°C).Accepted Author Manuscript(OLD)Applied Quantum Architecture
EFEKTIVITAS PASAL 1 PERATURAN DIREKTUR JENDRAL PAJAK NOMOR PER-18/PJ/2017
No full textTahap Penelitian atau yang penulis biasa sebut dengan validasi SSP (Surat Setoran Pajak) merupakan tahap final dimana seorang wajib pajak telah melakukan kewajibannya dalam penyetoran pajak, dan dalam proses validasi itu sendiri tidak semua akan diterima oleh kantor pajak setempat karena masih akan dilakukan penelitian baik penelitian serara formil maupun materiil. Untuk mekanismenya validasi telah ditetapkan dalam Per-18/Pj/2017 Tentang Cara Penelitian Bukti Pemenuhan Kewajiban Penyetoran Pajak Penghasilan Atas Penghasilan Dari Pengalihan Hak Atas Tanah Dan/Atau Bangunan, Dan Perjanjian Pengikatan Jual Beli Atas Tanah Dan/Atau Bangunan Beserta Perubahannya. Efektifitas pasal 1 Peraturan Direktur Jendral Pajak Nomor Per-18/Pj/2017 di Kantor Pajak Pratama Kota Malang telah sesuai akan tetapi untuk pasal 1 ayat 2 masih belum dan untuk pengikatan jual beli, dan mengenai cara pembuktian bahwa wajib pajak telah memenuhi kewajiban penyetoran adalah dengan cara validasi ataupun telah di telitiKata Kunci: kewajiban, penyetoran, pemenuhan, pajak, validasiThe Research Phase or what the author commonly refers to as SSP validation (Tax Payment Deposit) is the final stage in which a taxpayer has carried out his obligations in tax payments, and in the process of validation itself not all will be accepted by the local tax office because there will still be done a research both formal and material. For the mechanism of validation, it has been stipulated in Per-18 / Pj / 2017 Regarding the Method of Research of Evidence of Fulfillment of Obligation of Income Tax on Income from Transfer of Land and / or Building Rights, and Agreement on Binding of Sale and Purchase of Land and / or Buildings and Amendments. The effectiveness of article 1 of the Regulation of the Director General of Tax Number Per-18 / Pj / 2017 in the Pratama Tax Office Malang is appropriate but for article 1 paragraph 2 it is still not yet for the binding of buying and selling, and regarding the means of proving that the taxpayer has fulfilled the payment obligation is by validation or thoroughlyKeywords: oblilgation, deposit, fulfillment, tax, validatio
A Versatile and Efficient 0.1-to-11 Gb/s CML Transmitter in 40-nm CMOS
No full textWe present a wireline transmitter (TX) for re-configurable chip-to-chip links. The proposed design features a frequency-adaptive clock chain, a fast 16:1 clocked-CMOS multiplexer (C2MOS MUX) tree, and a full-rate synchronous current-mode logic (CML) clock driver. A prototype realized in 40-nm CMOS accomplishes a wide 0.1-to-11 Gb/s operation range (fmax/fmin = 110×). At 11 Gb/s, the prototype achieves 3.98 pJ/bit for a bit error rate (BER) < 10-12 with a 60.9-ps eye width.Accepted author manuscriptElectronic
The role of viruses in chronic rhinosinusitis
No full textThe original research contents of this PhD thesis followed an extensive review of the literature in terms of the viral contribution to chronic rhinosinusitis (CRS); this is described in chapter one. Understanding of the aetiopathogenesis of the disease is of course integral to CRS prevention and treatment. It is also a subject of debate; the roles of bacteria, fungi and disordered innate and adaptive immunity have been investigated. Viruses, however, have received little attention. A commonly encountered clinical paradigm is that of a patient complaining of a viral upper respiratory tract infection (URTI) with the development of CRS symptoms thereafter. This has been investigated in population virome studies, however results regarding any relationship between viruses and CRS these have been inconsistent. Most of these studies have been limited in terms of size, seasonality, viral collection methods and the viral species for which investigators assayed. None have validated their collection methods or investigated for any association between viral presence and more severe disease. In addition to these none have investigated virally-induced changes in the bacterial microbiome in CRS. Microbial disarray is an area of burgeoning interest in many chronic disease processes, CRS included. Respiratory viruses are known to augment local bacterial binding, penetration and persistence. Could virus-induced respiratory epithelial changes be contributing to the disease also? In order to investigate the above, the first step is to establish and validate a robust sinonasal viral collection method. This is described in the second chapter of this thesis. Sterile cytology brushes under direct endoscopic vision were used for this. 24 patients had two sites sampled immediately prior to endoscopic sinus surgery; the middle and inferior meatuses (MM and IM). Sample DNA and RNA were extracted and underwent PCR for a panel of common respiratory viruses, including the Herpesviridae and endogenous retrovirus 3 (ERV3). The former were chosen for their near-omnipresence in the adult sinuses, and the latter as a marker of sample quality. 18/24 were positive for virus in at least one site, including 8 who were positive at both sites. Only 3 of those 8 demonstrated the same viral species at both sites. 6 showed no virus at either site. All samples demonstrated ERV3 well within published ranges indicating adequate sample quality. From this we concluded that the cytobrushes are an effective method for viral sampling in the nose and sinuses. We also identified a significant discord in viral species between the MM and IM. As such we recommended that both sites are sampled in order to gain truly representative data. The third chapter of this thesis addresses the shortcomings of published population virome studies. The collection method detailed in the previous paragraph was used to sample from 288 patients over the period of one year. Disease severity data were also collected from these patients (Sino-Nasal Outcome Test 22 scores (SNOT-22), Adelaide Disease Severity Scores (ADSS), Lund MacKay scores (LMS) and Lund Kennedy scores (LKS)). Virus was found to be significantly more prevalent in CRS patients without nasal polyps (CRSsNP) than in controls or CRS patients with nasal polyps (CRSwNP). Viral presence was also found to be associated with significantly worse objective disease (LMS and LKS) but not subjective disease (SNOT-22 and ADSS). This is the first and only CRS virome study to encompass all subsets of the disease, to allow for seasonal variation in viral presence, and to use validated sample collection and processing techniques. We confirmed the long-held suspicion that viruses are more common in patients with CRS. As such we highlighted viruses as important potential targets for CRS prevention and therapy. The fourth chapter investigates the role of eosinophilia and T cell infiltrates in virus-positive versus virus-negative CRS and controls. Sinonasal tissue samples were taken and analysed for presence of eosinophils, CD8⁺, CD103⁺ and CD8⁺/CD103⁺ double-positive T cells (Trms). CRS was found to be associated with increased eosinophil and CD8⁺ CD103⁺ T cells in excess of that seen in virus-positive controls, implicating viruses in CRS aetiopathogenesis. The study detailed in the fifth chapter aimed to investigate virus-associated changes in the bacterial CRS sinonasal microbiome again by taking brushings of the sinonasal mucosa. These were analysed for viral presence and the bacterial microbiome was also characterised, using 16S ribosomal RNA gene-targeted amplicon sequencing. Patients were divided into control, non-polyp and polyp groups. Half of each group was virus-positive. No significant differences were seen in relative abundances of the bacterial genera detected, their diversity or stability in any of the groups. A trend towards greater relative abundance of Haemophilus spp. was seen in patients reporting a viral illness two to four weeks prior. This early microbiome shift may represent a nidus for superinfection contributing to the development of CRS.Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 202
Repurposing Mesalazine as a Potential Treatment Option for Chronic Rhinosinusitis
No full textThe research enclosed in this thesis revolves around investigating the therapeutic viability of repurposing the drug mesalazine into a sinonasal wash for the potential treatment of chronic rhinosinusitis (CRS). This body of work utilises an in vitro and in vivo experiments to evaluate the safety and efficacy of mesalazine as an emerging treatment option. This thesis is comprised of 6 chapters, each chapter representing different aspects of developing potential treatments for CRS. This includes exploring the current understanding and treatment options available in CRS, repurposing mesalazine into an appropriate sinonasal wash, testing it’s safety and efficacy in vitro, developing an appropriate in vivo inflammatory model and finally, establishing the effects of mesalazine on sinonasal inflammation in vivo. Chapter 1 functions as an introductory chapter, exploring the fundamental concepts of CRS that lay the foundational work for the coming chapters. This chapter is broken down into six parts. The first and second section provide a concise overview and epidemiology of CRS, respectively. The third section focuses on the aetiology of CRS. The fourth section delves deeper into the immune system and the cells within it that are associated with CRS. The final sections concentrate on the current treatment options for CRS and lastly propose mesalazine as a potential treatment option for CRS. Chapter 2 is a manuscript examining repurposing mesalazine into a sinus wash, and investigating its safety in vitro on human nasoepithelial cells, whilst still retaining its antiinflammatory function. From this an appropriate dosing range was established which maximised anti-inflammatory effects and minimised cell toxicity. Chapter 3 is rat sinusitis model. This chapter centered around creating a new inflammatory small animal model that is cheap, easily accessible and non-invasive, and mimics the lymphoplasmacytic histopathology seen in a subset of patients with difficult to treat CRS. Chapter 4 is a manuscript that ties the two previous chapter together by investigating the effects of mesalazine on sinonasal inflammation in the established rat model. Mesalazine was also compared to current treatments available for CRS in vivo. The systemic effects were also investigated. Finally, in Chapter 6, conclusions are drawn and future directions of research are reflected upon. Mesalazine presents as a potential therapeutic option for the treatment of CRS through its anti-inflammatory effects. Whilst the work embodies in this thesis looks at the effects of mesalazine in vitro and in vivo, future directions should be aim at investigating its effects in human clinical trials.Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 202
Dacryocystorhinostomy ostium: parameters to evaluate and DCR ostium scoring
No full textMohammad Javed Ali,1 Alkis James Psaltis,2 Peter John Wormald2 1Dacryology Service, L V Prasad Eye Institute, Hyderabad, Telangana, India; 2Department of Surgery–Otorhinolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia Aim: This study aims to provide a systematic protocol for the evaluation of a dacryocystorhinostomy (DCR) ostium and to propose a scoring system to standardize the assessment.Methods: Retrospective evaluation of 125 consecutive lacrimal ostia post-DCR was performed. Medical records were screened, and photographs and videos were assessed to note the details of various ostial parameters. The major time points in evaluation were 4 weeks, 6 weeks, 3 months, and 6 months post-DCR. The ostia were defined and parameters like shape, size, location, and evolution of ostium were noted. Evaluation parameters were defined for internal common opening (ICO), ostium stents, and ostium granulomas. Ostium cicatrix and synechiae were graded based on their significance. Surgical success rates were computed and ostium characteristics in failed cases were studied.Results: A total of 125 ostia were evaluated on the aforementioned ostium parameters. Because five ostia showed a complete cicatricial closure with no recognizable features, the remaining 120 ostia were studied. The ostium location was anterior to the axilla of middle turbinate in 85.8% (103/120) of the cases. Moreover, 76.6% (92/120) of the ostia were circular to oval in shape, with a shallow base. The ostium size was >8×5 mm in 78.3% (94/120) of the cases. The ICO was found to be located in the central or paracentral basal area in 75.8% (91/120). The anatomical and functional success rates achieved were 96% and 93.6%, respectively. All the five cases with anatomical failures showed a complete cicatrization and the ICO movements were poor in all the three cases of functional failure.Conclusion: The article attempts to standardize the postoperative evaluation of a DCR ostium and provides a systematic protocol and scoring system for possible use by surgeons and researchers alike. Keywords: DCR, ostium, score, lacrimal, nasal endoscop
A Differential Transmission Gate Design Flow for Minimum Energy Sub-10-pJ/Cycle ARM Cortex-M0 MCUs
No full textUltra-low voltage operation is key to achieving energy-efficient operation for microcontroller (MCU) systems. Variation resiliency, high speed operation, and short design time are the most important challenges for these systems. This paper overcomes these challenges in a new design strategy that enables standard cell design with differential transmission gate logic. The commercial toolchain is extended with in-house developed add-ons and makes use of two custom libraries with different device lengths to allow high speed vs. low leakage trade-offs. The design flow is used to prototype two highly efficient 32-bit ARM Cortex-M0 MCU systems in 40-nm CMOS. The core of the first prototype scales down to 190 mV and 0.8-MHz and reaches 16.07 pJ/cycle at 31.2-MHz and 440 mV. The second prototype benefits from the dual libraries and reduces core energy consumption by 50% at the same speed performance. Minimum energy operation is thus achieved at an even lower voltage (370 mV) with the M0 core consuming only 8.80 pJ/cycle at 13.7-MHz, breaking the sub-10-pJ/cycle barrier for a 6–35-MHz range.sponsorship: This paper was approved by Guest Editor Eugenio Cantatore. This work was supported by the IWT-Agency for Innovation by Science and Technology. (Corresponding author: Hans Reyserhove.) (IWT-Agency for Innovation by Science and Technology)status: Publishe
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