873 research outputs found
HIV Prevention in Care and Treatment Settings: Baseline Risk Behaviors among HIV Patients in Kenya, Namibia, and Tanzania.
No full textHIV care and treatment settings provide an opportunity to reach people living with HIV/AIDS (PLHIV) with prevention messages and services. Population-based surveys in sub-Saharan Africa have identified HIV risk behaviors among PLHIV, yet data are limited regarding HIV risk behaviors of PLHIV in clinical care. This paper describes the baseline sociodemographic, HIV transmission risk behaviors, and clinical data of a study evaluating an HIV prevention intervention package for HIV care and treatment clinics in Africa. The study was a longitudinal group-randomized trial in 9 intervention clinics and 9 comparison clinics in Kenya, Namibia, and Tanzania (N = 3538). Baseline participants were mostly female, married, had less than a primary education, and were relatively recently diagnosed with HIV. Fifty-two percent of participants had a partner of negative or unknown status, 24% were not using condoms consistently, and 11% reported STI symptoms in the last 6 months. There were differences in demographic and HIV transmission risk variables by country, indicating the need to consider local context in designing studies and using caution when generalizing findings across African countries. Baseline data from this study indicate that participants were often engaging in HIV transmission risk behaviors, which supports the need for prevention with PLHIV (PwP). TRIAL REGISTRATION: ClinicalTrials.gov NCT01256463
Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection
No full textAlthough the pathogenesis of human immunodeficiency virus (HIV) infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, there are unique considerations needed for HIV-infected infants, children, and adolescents, including; A acquisition of infection through perinatal exposure for many infected children, In utero, intrapartum, and/or postpartum neonatal exposure to zidovudine (ZDV) and other antiretroviral medications in most perinatally infected children, Requirement for use of HIV virologic tests to diagnose perinatal HIV infection in infants under age 15 to 18 months old, Age-specific differences in immunologic markers (i.e., CD4+ T cell count), Changes in pharmacokinetic parameters with age caused by the continuing development and maturation of organ systems involved in drug metabolism and clearance, Differences in the clinical and virologic manifestations of perinatal HIV infection secondary to the occurrence of primary infection in growing, immunologically immature persons, and Special considerations associated with adherence to antiretroviral treatment for infants, children and adolescents. This report addresses the pediatric-specific issues associated with antiretroviral treatment and provides guidelines to health care providers caring for infected infants, children, and adolescents. It is recognized that guidelines for antiretroviral use in pediatric patients are rapidly evolving. The Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children will review new data on an ongoing basis and provide regular updates to the guidelines
Averting HIV Infections in New York City: A Modeling Approach Estimating the Future Impact of Additional Behavioral and Biomedical HIV Prevention Strategies
No full textBackground:New York City (NYC) remains an epicenter of the HIV epidemic in the United States. Given the variety of evidence-based HIV prevention strategies available and the significant resources required to implement each of them, comparative studies are needed to identify how to maximize the number of HIV cases prevented most economically.Methods:A new model of HIV disease transmission was developed integrating information from a previously validated micro-simulation HIV disease progression model. Specification and parameterization of the model and its inputs, including the intervention portfolio, intervention effects and costs were conducted through a collaborative process between the academic modeling team and the NYC Department of Health and Mental Hygiene. The model projects the impact of different prevention strategies, or portfolios of prevention strategies, on the HIV epidemic in NYC.Results:Ten unique interventions were able to provide a prevention benefit at an annual program cost of less than 106,378; the total cost was in excess of 100 million per year, on average). The cost-savings of prevented infections was estimated at more than 250 million per year, on average).Conclusions:Optimal implementation of a portfolio of evidence-based interventions can have a substantial, favorable impact on the ongoing HIV epidemic in NYC and provide future cost-saving despite significant initial costs. © 2013 Kessler et al
The Economics of HIV/AIDS in Low-Income Countries: The Case for Prevention
No full textThere are two approaches to reducing the burden of sickness and death associated with HIV/AIDS: treatment and prevention. With limited resources, should the focus be on prevention or treatment? I discuss the range of prevention and treatment alternatives, examine their cost effectiveness, and consider various arguments that have been raised against the use of cost-effectiveness analysis in setting priorities for health. I conclude that promoting AIDS treatment using antiretrovirals in resource-constrained countries comes at a huge cost in terms of avoidable deaths that could be prevented through interventions that would substantially lower the scale of the epidemic.HIV, AIDS, low income countries, treatment, prevention
Dyad-related factors in HIV prevention
No full textIncludes bibliographical references (leaves 213-234).[Objectives] Currently, HIV prevention strategies focus on promoting the modification of those individual behaviours that lead to an increase in susceptibility to and transmission of HIV infection. The focus on individuals in HIV voluntary counselling and testing frequently overlooks the fact that communication and collaboration between the sexual partners is required to effect any behavioural change within an intimate partnership. Developing HIV prevention strategies targeting couples is therefore noted to be increasingly relevant for improving HIV/STI risk reduction uptake. Couple HIV counselling and testing (CHCT) is a strategy that aims to bridge this gap by providing a safe environment for partners to be tested and counselled together. In this way, the burden of disclosing one's HIV status to one's partner is eliminated, and the difficulties experienced by the tested individual in negotiating risk reduction uptake are significantly reduced. There is a paucity of data regarding couples' experiences in and perceptions of CHCT within the South African setting. This study explores couples' experiences before, during and after CHCT; determines the socio-behavioural risk factors for HIV status in couples; explores the impact of couple HIV status on fertility desires, and lastly examines the reliability of inter-partner reports on sexual and other behaviours. [Methods] This was a cross-sectional study with baseline and follow-up components; in addition to a qualitative study component. Structured interviewer-administered questionnaires were applied to each member of the couple separately at baseline prior to CHCT (n=600 couples), immediately post CHCT, and at least 1 month post the CHCT process (n= 258 couples). In addition, in-depth qualitative interviews were done with each member of 27 couples at least one month post CHCT. [Results] Overall, the HIV prevalence in the study sample was 30% (24% in male and 35% in the female participants). Of the 600 couples tested for HIV, 354 (59%) were HIV concordant negative, 136 (23%) were HIV serodiscordant and 110 (18%) were HIV concordant positive. Of the HIV serodiscordant, 101(74%) were couples in which the female was the HIV positive partner and 35 (26%) had HIV positive males. Contextual factors such as community perceptions and levels of HIV-related stigma significantly influenced the couples' decision to test for HIV. Couples reported improved risk reduction uptake and improved communication as well as general improvements in other aspects of their lives at follow-up post the CHCT process. Factors such as community and family expectations as well as financial stability seemed to play a more influential role as determinants of fertility desire, compared to the couple HIV status. Comparison of couples' responses to some questions regarding sexual and other behaviours revealed that there was low inter-partner agreement particularly with respect to questions regarding communication behaviours. Key findings indicate that CHCT was acceptable to the couples who attended this process, and yet, making the decision to test was difficult for most couples. Partners devised various strategies to initiate the discussion on the need to test for HIV. However, after CHCT attendance, the process was highly rated, regardless of gender or resultant HIV status. [Conclusion] In order to increase the usefulness and effectiveness of CHCT, the process must be able to address pertinent uncertainties and concerns that couples might have with regard to HIV risk-reduction uptake and fertility desires
The potential impact of pre-exposure prophylaxis for HIV prevention among men who have sex with men and transwomen in Lima, Peru: a mathematical modelling study.
No full textBACKGROUND: HIV pre-exposure prophylaxis (PrEP), the use of antiretroviral drugs by uninfected individuals to prevent HIV infection, has demonstrated effectiveness in preventing acquisition in a high-risk population of men who have sex with men (MSM). Consequently, there is a need to understand if and how PrEP can be used cost-effectively to prevent HIV infection in such populations. METHODS AND FINDINGS: We developed a mathematical model representing the HIV epidemic among MSM and transwomen (male-to-female transgender individuals) in Lima, Peru, as a test case. PrEP effectiveness in the model is assumed to result from the combination of a "conditional efficacy" parameter and an adherence parameter. Annual operating costs from a health provider perspective were based on the US Centers for Disease Control and Prevention interim guidelines for PrEP use. The model was used to investigate the population-level impact, cost, and cost-effectiveness of PrEP under a range of implementation scenarios. The epidemiological impact of PrEP is largely driven by programme characteristics. For a modest PrEP coverage of 5%, over 8% of infections could be averted in a programme prioritising those at higher risk and attaining the adherence levels of the Pre-Exposure Prophylaxis Initiative study. Across all scenarios, the highest estimated cost per disability-adjusted life year averted (uniform strategy for a coverage level of 20%, US4,254) is below the World Health Organization recommended threshold for cost-effective interventions, while only certain optimistic scenarios (low coverage of 5% and some or high prioritisation) are likely to be cost-effective using the World Bank threshold. The impact of PrEP is reduced if those on PrEP decrease condom use, but only extreme behaviour changes among non-adherers (over 80% reduction in condom use) and a low PrEP conditional efficacy (40%) would adversely impact the epidemic. However, PrEP will not arrest HIV transmission in isolation because of its incomplete effectiveness and dependence on adherence, and because the high cost of programmes limits the coverage levels that could potentially be attained. CONCLUSIONS: A strategic PrEP intervention could be a cost-effective addition to existing HIV prevention strategies for MSM populations. However, despite being cost-effective, a substantial expenditure would be required to generate significant reductions in incidence. Please see later in the article for the Editors' Summary
Barriers to prevention of mother-to-child transmission of HIV services in Uganda.
No full textUnderstanding care-seeking practices and barriers to prevention of mother-to-child transmission (PMTCT) of HIV is necessary in designing effective programmes to address the high disease burden due to HIV/AIDS in Uganda. This study explored perceptions, care-seeking practices and barriers to PMTCT among young and HIV-positive women. A household survey (10,706 women aged 14-49 years), twelve focus group discussions and 66 key informant interviews were carried out between January and April 2009 in Wakiso district, central Uganda. Results show that access to PMTCT services (family planning, HIV counselling and testing and delivery at health units) was poor. Decision making was an important factor in accessing PMTCT services. Socioeconomic factors (wealth quintile, age, education level) and institutional practices also influenced access to PMTCT. Overall, having had an HIV test was highest when both men and women made decisions together or when women were empowered to make their own decisions. This was significant across wealth quintiles (p=0.0001), age groups (p=0.0001) and education levels (p=0.0001). The least level of HIV testing was when men made decisions for their spouses; and this was the case with family planning and deliveries at health units. Other barriers to PMTCT were fear of women and male spouses to have an HIV test and the perception that HIV testing is compulsory in antenatal clinics. In conclusion, to increase access to PMTCT among women, especially the young, poor and least educated, there is a need to empower them to make decisions on health seeking, and also to empower men to support their spouses to make good decisions. Other barriers like fear of having an HIV test should be addressed through appropriate counselling of clients
HIV/AIDS prevention policy processes in faith-based non-governmental organizations in Tanzania
No full textMany faith-based organizations (FBOs) are providing valuable care and support to people living with and affected by HIV/AIDS. The overall response of FBOs, however, has been controversial, particularly in regards to HIV/AIDS prevention and FBO’s rejection of condom use and promotion. This response has negatively influenced national HIV/AIDS prevention response efforts.
The aim of this thesis is to explore the factors influencing the HIV/AIDS prevention policy process within faith-based non-governmental organizations (NGOs) of different faiths, and in particular how faith is reflected in and interacts with this process. These processes were examined within three faith-based NGOs in Dar es Salaam, Tanzania – a Catholic, Anglican and Muslim organization. The research used an exploratory, qualitative case-study approach. It employed a health policy analysis framework, examining the context, actor, and process factors and how they interact to form content in terms of policy and practice within each organization.
Three key factors were found to influence faith-based NGOs’ HIV/AIDS prevention policy process in terms of both policy development and implementation: 1) the faith structure in which the organizations are a part, 2) the presence or absence of organizational policy, and 3) the professional nature of the organizations and its actors. The interaction between these factors, and how actors negotiate between them, was found to shape an organization’s HIV/AIDS prevention policy process.
By understanding the factors and processes that influence faith-based NGOs’ HIV/AIDS prevention policy process, and how this conflicts with the national policy response, more appropriate policies can be developed and implemented within faith-based NGOs. Furthermore, the government may be better able to identify how best to intervene and/or work with faith-based NGOs in order to meet their HIV/AIDS prevention targets, and achieve a more uniform and evidence-based approach to HIV/AIDS prevention
Breastfeeding and HIV: Experiences from a Decade of Prevention of Postnatal HIV Transmission in Sub-Saharan Africa.
No full textInfant feeding by HIV-infected mothers has been a major global public health dilemma and a highly controversial matter. The controversy is reflected in the different sets of WHO infant feeding guidelines that have been issued over the last two decades. This thematic series, 'Infant feeding and HIV: lessons learnt and ways ahead' highlights the multiple challenges that HIV-infected women, infant feeding counsellors and health systems have encountered trying to translate and implement the shifting infant feeding recommendations in different local contexts in sub-Saharan Africa. As a background for the papers making up the series, this editorial reviews the changes in the guidelines in view of the roll out of prevention of mother to child transmission (PMTCT) programmes in sub-Saharan Africa between 2001 and 2010
Personal, interpersonal and structural challenges to accessing HIV testing, treatment and care services among female sex workers, men who have sex with men and transgenders in Karnataka state, South India.
No full textBACKGROUND: Despite high HIV prevalence rates among most-at-risk groups, utilisation of HIV testing, treatment and care services was relatively low in Karnataka prior to 2008. The authors aimed to understand the barriers to and identify potential solutions for improving HIV service utilisation. METHODS: Focus group discussions were carried out among homogeneous groups of female sex workers, men who have sex with men and transgenders, and programme peer educators in six districts across Karnataka in March and April 2008. RESULTS: 26 focus group discussions were conducted, involving 302 participants. Participants had good knowledge about HIV and HIV voluntary counselling and testing (VCT) services, but awareness of other HIV services was low. The fear of the psychological impact of a positive HIV test result and the perceived repercussions of being seen accessing HIV services were key personal and interpersonal barriers to HIV service utilisation. Previous experiences of discrimination at government healthcare services, coupled with discriminatory attitudes and behaviours by VCT staff, were key structural barriers to VCT service uptake among those who had not been HIV tested. Among those who had used government-managed prevention of parent to child transmission and antiretroviral treatment services, poor physical facilities, long waiting times, lack of available treatment, the need to give bribes to receive care and discriminatory attitudes of healthcare staff presented additional structural barriers. CONCLUSIONS: Embedding some HIV care services within existing programmes for vulnerable populations, as well as improving service quality at government facilities, are suggested to help overcome the multiple barriers to service utilisation. Increasing the uptake of HIV testing, treatment and care services is key to improving the quality and longevity of the lives of HIV-infected individuals
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