156,360 research outputs found
La Megale Ekklesia nelle pagine di Procopio di Cesarea
No full textIl contributo analizza la sezione del De Aedificiis di Procopio di Cesarea dedicata a Santa Sofia di Costantinopoli (I, 1, 20-78). Esso, all’interno del passo, individua quattro temi e li indaga, sottolineando l’apporto originale offerto dal principale storico contemporaneo alla comprensione del capolavoro architettonico bizantino: a) il panegirico di Giustiniano; b) la descrizione della chiesa e delle sue strutture portanti; c) i problemi strutturali sorti in corso d’opera; d) alcune riflessioni sul tema della luce e sulla percezione
Migration of mesothelioma cells correaltes with histotype specific synthesis of extracellular matrix.
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Characterization of a railways system overhead transmission line excited by a lightning electromagnetic field
No full textWe present a new field-to-line coupling model for the analysis of overvoltage on overhead dc traction power lines of modern electric mass-transit systems, such as Light Rail Transportation Systems (LRTS), in the case of a lightning strike in the vicinity of the line. The developed model is essentially based on a mathematical procedure involving suitable expansions of the induced currents and of the scattered voltages by means of a series of Gegenbauer polynomials. Such a procedure allows the integro-differential system describing the fieldto- line coupling problem to be solved with faster performances in comparison to more classical “full-Maxwell” approaches (e.g. MOM, FDTD) for a given accuracy.
This feature makes it possible to find, in a reasonable time, a frequency domain representation of the contact line in terms of a matrix of impedances and open circuited voltages in response to several lightning strikes, taking into account the effect of radiated power, which is not modelled by the classical transmission line approach.
This phenomenon is usually quite relevant for typical contact line geometries, since they are characterized by transversal dimensions that are not negligible with respect to the relatively short length of each overhead section. This representation is suitable for a future integration (in a case using modal analysis) in a time domain model that can be analyzed by means of a circuit simulator.
The evaluation of the effects of several lightning strikes with different impact points and characteristics will allow a statistical assessment of the protection level offered by different technical solutions to be performed (by way of example, the different location of the surge arresters)
Renal Cancer
No full textRenal cell carcinoma (RCC) is a tumor where new biological knowledge has changed the landscape: indeed, antiangiogenic agents and immunotherapy are changing the natural history of disease. New discoveries in targeted therapy are paralleled by those in immunotherapy: the treatment paradigm continues to evolve.
The currently available drugs do not benefit every patient equally. Biological factors particular to certain individuals have a clear effect on this variation in response.
Given the increasing number of treatment options but without the same benefit for every patient, the patient selection in the future will be the key. Predictive biomarkers are required for treatment personalization.
Multidisciplinarity is important also for the emerging role of cytoreductive nephrectomy and metastasectomy in selected cases.
The future is represented by new drugs, new combinations, and the development of precision therapy
Da Teodora a Sarah: la fonte e il mediatore
No full textIl contributo esamina l'atteggiamento di Victorien Sardou nei confronti dello storico Procopio per l'elaborazione della figura scenica di Teodora
Lightning return stroke current radiation in presence of a conducting ground: 2. Validity assessment of simplified approaches
No full textIn this paper, the developed formulation, which we shall call the “reference” one, is used to assess the validity of the most popular simplified approach for the calculation of the lightning electromagnetic field over a conducting earth, namely, the Cooray-Rubinstein (CR) approximation. This formula provides a simple method to evaluate the radial component of the electric field which is the component most affected by the finite ground conductivity and which plays an important role within the Agrawal et al. (1980) field-to-transmission line-coupling model. Several configurations are examined, with different values for the ground conductivity and different field observation points. A thorough analysis of all the simulated field components is carried out and comparisons are also made with the “ideal” field, namely, the field that would be present under the assumption of perfectly conducting ground. It is shown that for channel base current typical of subsequent strokes and for very low conductivities, the CR formula exhibits some deviations from the reference one but it still represents a conservative estimation of the radial field component, since it behaves as un upper bound for the exact curve. The developed algorithm is characterized by fast performances in terms of CPU time, lending itself to be used for several applications, including a coupling code for lightning induced overvoltages calculations.SCI-STI-FRLR
Expression and diversity of AMP and other immune-related molecules in M. galloprovincialis
No full textAnthropogenic activities, accidental events and global climate trends currently threaten the marine biological resources as they impose functional adjustments to the biota, change the ecological niches and lead to significant ecosystem changes. In the water column or sediments, bivalves interact with a variety of microorganisms which include commensal, opportunistic species and potential pathogens. Ofter acting together with other detrimental factors, microscopic agents can divert energy from growth and reproduction to the defence reactions, and finally overwhelm the host defenses with onset of diseases and mortality outbreaks in the natural and farmed stocks. Mussels of the genus Mytilus commonly appear more resilient than other bivalves to the environmental variation, and more likely act as pathogen reservoir for the animal species sharing the same habitat. In the frame of the European Integrated project IMAQUANIM, standard and advanced sequencing is confirming abundance and molecular diversity of the antimicrobial peptide precursors expressed in farmed, wild and immunostimulated mussels. Transcripts denoting pathogen recognition receptors also showed significant molecular diversity, namely sequences containing C1q, C-type-lectin or fibrinogen-like domains. Overall, gene expression profiling and massive sequencing progressively unveil the complexity of the innate defences of the Mediterranean mussel
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