103,188 research outputs found
Forty-nine colorectal cancer liver metastases in one-stage hepatectomy with cumulative Pringle time lasting 348 min
No full textTailoring the area of hepatic resection using inflow and outflow modulation
No full textThe performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure. The key factor of modern hepatic surgery is the use of the intraoperative ultrasound (IOUS), not only to stage the disease, but more importantly to guide resection with the specific aim to maximize the sparing of the functional parenchyma. Whether in patients with hepatocellular carcinoma and underlying liver cirrhosis, or in patients with colorectal liver metastasis, IOUS allows the performance of the so-called "radical but conservative surgery", which is the pivotal factor to offer a chance of cure to an increasing proportion of patients, who until few years ago were considered only for palliative care. Using some new IOUS-guided surgical maneuvers, which are based on the liver inflow and outflow modulations, more precise anatomically subsegmental- and segmental-oriented resections can be effectively performed. The present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in IOUS. Such important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon. (C) 2013 Baishideng. All rights reserved
Post-docetaxel therapy in castration resistant prostate cancer - the forest is growing in the desert.
No full textIn Europe, prostate cancer is the most common cancer among men with 382.000 new cases and 89.000 deaths annually. Historically, androgen deprivation therapy and docetaxel based chemotherapy were the only treatments able to improve survival. Two studies have been published during last few months regarding the management of castration resistant prostate cancer (CRPC) progressed after docetaxel: for the first time second line therapies have been demonstrated to improve prognosis of these patients. The relevance of these trials is the reintroduction of chemotherapy and hormonal therapy in a disease once considered chemotherapy and castration resistant. All these data may change the traditional approach to CRPC but no evidences have came out from recently closed or ongoing clinical trials about the therapeutic algorithm. How to get oriented in this forest? We propose that patient's conditions, response and toxicities reported with previous treatments and, above all, dynamics and evolution of disease may influence the choice of subsequent therapies in docetaxel progressed CRPC. © The Author(s), 2012
Hydrodynamic Green functions: paradoxes in unsteady Stokes conditions and infinite propagation velocity in incompressible viscous models
No full textWe present a simple representation of the hydrodynamic Green functions grounded on the free propagation of a vector field without any constraints (such as incompressibility) coupled with a gradient gauge in order to enforce these constraints. This approach involves the solution of two scalar problems: a couple of Poisson equations in the case of the Stokes regime, and a system of diffusion/Poisson equations for unsteady Stokes flows. The explicit and closed-form expression of the Green function for unsteady Stokes flow is developed. The relevance of this approach resides in its conceptual simplicity and it enables us to focus on the intrinsic singularities (Stokesian paradoxes) associated with the propagation of the stresses in incompressible flows under unsteady Stokes conditions, determining the occurrence of power-law tails in the velocity profile arbitrarily far away from the location of the impulsive force
Re: Camillo Porta, Emiliano Calvo, Miguel A. Climent, et al. Efficacy and Safety of Everolimus in Elderly Patients With Metastatic Renal Cell Carcinoma: An Exploratory Analysis of the Outcomes of Elderly Patients in the RECORD-1 Trial. Eur Urol 2012;61:826-33
No full textTargeted therapies and survival: What we can learn from studies in advanced renal cell carcinoma
No full text
[Nicolai Alemanni De Procopio et arcana eius historia indicium]
No full textTit. y autor tomados de prefacioTexto paralelo griego-latÞn de p. XIX-XXIII y p. 1-135Pie de imp. tomado de colofónSign.: a¬2-5, e¡3, i¡2, o¡4, A-R¡4, a-c¡4, d¬1, d¬3-4, e¡4, f¬2-3, g-i¡4, k¬1, k¬4, l-u¡4Error de pag., de p. 112 pasa a 115Texto a dos colContiene: Historia arcana / Procopius de Cesarea, p. 1-135Notas históricas a la Historia arcana de Procopio / Nicola s Alemanni, p. 1-14
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