1,720,996 research outputs found
FOTOCHEMIOTERAPIA DELLA VITILIGINE CON KELLINA ED ESPOSIZIONE ALLA LUCE SOLARE
No full textPhotochemotherapy of vitiligo is an extremely common treatment. A major problem in the use of psoralens in photochemotherapy is the hazard of mutagenicity and cutaneous phototoxicity. For that reason we have used an other photosensitizing: khellin. We have treated for 6 months two groups of patients either with topycal application or via sistemic administration of khellin and subsequent exposure to solar radiation. 50-60% of all patients have partially repigmented. No side effects have been observed. Results obtained in both groups of patients are discussed
Non-ionizing electromagnetic radiations, emitted from cellular phone, modify cutaneous blood flow.
No full textBACKGROUND:
Our surroundings are full of non-ionizing electromagnetic radiation (EMR) of different frequency and power. The non-ionizing EMRs emitted by television, computer and cellular phone (CF) sets have been increasing over the past few years.
OBJECTIVE:
The aim of our study was to assess the effects of non-ionizing EMRs (frequency 3 x 10(8) to 3 x 10(11) Hz), emitted by CFs, on cutaneous blood flow in healthy volunteers.
METHODS:
Thirty healthy volunteers (14 male and 16 female; age: 18-53 years) entered the study. Measurements of cutaneous blood flow were taken under standard conditions (temperature and humidity), using a laser Doppler He-Ne flowmeter that was applied to the ear skin by an optical fibre probe. Microflow values were recorded without CF contact with the skin (T0), with the CF turned off but in contact with the ear skin (T1), with CF contact and turned on (T2), with CF contact, turned on and receiving (T3). The microflow values were also recorded backwards: with CF contact and set turned on (T4), with CF contact and turned off (T5), without CF contact (T6).
RESULTS:
The mean value of basal microflow (T0), expressed as perfusion units (PU), was 51.26+/-11.93 PU. During the T1 phase, the microflow increase was 61.38%; in T2 it was 131.74%, in T3 157.67%, in T4 139.21% and in T5 122.90%; in T6, the microflow value was 57.58+/-10 PU (similar to the basal microflow). Statistically significant cutaneous microflow values (p<0.050) were observed comparing the T1 to T5 values with basal microflow (T0). Furthermore, in comparison with T1 values (CF turned off in contact with the ear skin), the T2, T3 and T4 data were statistically significant (T2 vs. T1: t=7.763 with p<0.050; T3 vs. T1: t=9.834 with p<0.050; T4 vs. T1: t=8.885 with p<0.050)
VITILIGINE A PICCOLE CHIAZZE: ABRASIONE EPIDERMICA E 5-FU VERSUS ABRASIONE EPIDERMICA E CYA
No full textA group of 88 patients affected with vitiligo were treated by epidermoabrasion and daily applications of 5-fluorouracil (5-FU) or cyclosporin A (CyA) with occlusive dressing for 15 days. Repigmentation was observed in 70% patients treated with 5-FU and in 5,5% of patients treated with CyA. Repigmentation appeared 4-8 weeks after suspension of treatment and was complete after 5-6 months. No side effects were observed. The action of the two drugs is discussed
Topical administration of hematoporphyrin derivative and red light irradiation. A therapeutic approach in psoriasis
No full textA controlled trial of topical photochemotherapy of plaque-type psoriasis using hematoporphyrin derivative (HPD) in combination with red light (590-700 nm) was performed on 8 patients. For each patient HPD (1%) in N-methylpyrrolidone was applied on one psoriatic patch, only the vehicle being applied on the control one. Both patches were daily irradiated with incoherent red light (60 J/cm2/day) for a week. Comparative evaluation of clinical and histologic results are discussed
Effect of psoralen and ultraviolet A on platelet functioning: an in vitro and in vivo study
No full textWe investigated possible alterations induced by psoralen and ultraviolet A radiation (PUVA) on platelet function both in vitro and in vivo. In vitro, using conventional aggregometry and adenosine diphosphate (ADP), collagen, ristocetin and arachidonic acid as aggregating agents, platelet aggregation was determined on platelet-rich plasma (PRP) from normal subjects at basal conditions and following the addition of increasing concentrations of 8-methoxypsoralen (8-MOP) with and without exposure to ultraviolet A (UVA) light (5 J/cm2) and compared with UVA light exposure alone. At basal conditions and following exposure to UVA light alone, no changes in the normal platelet aggregation patterns were observed. Exposure to UVA light of PRP containing 8-MOP also demonstrated no abnormality in the platelet aggregation patterns at 8-MOP concentrations of 200 ng/ml. However, abnormal platelet aggregation as a response to ADP and collagen was observed at higher concentrations of 8-MOP, which was augmented upon exposure to UVA light. In vivo, platelet aggregometry was performed on PRP from 4 patients submitted to PUVA treatment at basal conditions, 2.5 h after oral ingestion of 8-MOP (0.6-0.8 mg/kg) and after 4 PUVA sessions. No patient showed modification of the platelet aggregation profile after either 8-MOP ingestion or PUVA treatment. Our study shows that 8-MOP at high concentrations in vitro impairs platelet aggregation by ADP and collagen augmented by UVA light exposure, but PUVA therapy causes no detectable abnormality in platelet function in vivo
Determination of light transmission through summer clothes
No full textA great number of dermatological patients, in particular during summer time, need photo-protection measures. Nevertheless there are no scientific data on the filtrating capacity of summer clothes. In this study the transmittion of visible light and ultraviolet radiation, UVB and UVA light, has been measured through various samples of common summer clothing fabrics. The results show that type and structure (warf and woof) of tissues are more important than colour in determining the protective nature of the material
TRATTAMENTO ASSOCIATO UVB-DITRANOLO IN PAZIENTI CON PSORIASI A PLACCHE
No full textThe purpose of this study was to determine whether the combination of ultraviolet B therapy and anthralin would result in a more rapid resolution of plaque-type psoriasis. Short-contact anthralin (0.5% in petrolatum) was used. Ultraviolet B irradiation was carried out 5 times a week with a bank of 8 Philips TL 40W/12 tubes (irradiance, 1 mW/cm2 30 cm). Out of the 14 patients studied, seven (group I) were given anthralin for 15 days before practicing UVB therapy and seven (group II) carried out phototherapy sessions for 15 days before the combination of both treatments. These results show both a more rapid clearance of psoriatic plaques and lower UVB total dose with anthralin pretreatment
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