903 research outputs found
Philosophische Überlegungen zu Hirntod und Organspende
No full textStoecker R. Philosophische Überlegungen zu Hirntod und Organspende. In: Probst SM, ed. Hirntod und Organspende aus interkultureller Sicht. 1st ed. Leipzig: Hentrich & Hentrich Verlag; 2019: 85-101
Jewish Orthodox Perspectives on Brain Death and Organ Donation: Contested Knowledge between Scientific Determinations and Religious Normativity
No full textBiogeochemical redox proxies in sediments from Dotternhausen during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Biogeochemical redox proxies in sediments from Yorkshire during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Bikkur Cholim, Jewish healthcare chaplaincy and spiritual care: three culturally influenced concepts of patient-centered care
No full textCatalytic P-H activation by Ti and Zr catalysts
No full textCatalytic dehydrocoupling of phosphines was investigated using the anionic zirconocene trihydride salts [Cp*Zr-2(mu-H)(3)Li](3) (1a) or [Cp*Zr-2(mu-H)(3)K(thf)(4)] (1b), and the metallocycles [CpTi(NPtBu3)(CH2)(4)] (6) and [Cp*M(NPtBu3)(CH2)(4)] (M = Ti 20, Zr 21) as catalyst precursors. Dehydrocoupling of primary phosphines RPH2 (R = Ph, C6H2Me3, Cy, C10H7) gave both dehydrocoupled dimers RP(H)P(H)R or cyclic oligophosphines (RP)(n) (n = 4, 5) while reaction of tBu(3)C(6)H(2)PH(2) gave the phosphaindoline tBu(2)(Me2CCH2)C6H2PH (9). Stoichiometric reactions of these catalyst precursors with primary phosphines afforded [Cp*Zr-2((PR)(2))H][K(thf)(4)] (R = Ph 2, Cy 3, C6H2Me3 4), [Cp*Zr-2((PPh)(3))H] [K(thf)(4)] (5), [CpTi(NPtBu3)(PPh)(3)] (7) and [CpTi(NPtBu3)(mu-PHPh)](2) (8), while reaction of 6 with (C(6)H(2)tBu3)PH2 in the presence of PMe3 afforded [CpTi(NPtBu3)(PMe3)(p(C(6)H(2)tBu(3))] (10). The secondary phosphines Ph2PH and (PhHPCH2)(2)CH2 also undergo dehydrocoupling affording (Ph2P)(2) and (PhPCH2)(2)CH2. The bisphosphines (CH2PH2)(2) and C6H4(PH2)(2) are dehydrocoupled to give (PCH2CH2PH)(2) (12) and (C6H4P(PH))(2) (13) while prolonged reaction of 13 gave (C6H4P2)(8) (14). The analogous bisphosphine Me2C6H4(PH)(2) (17) was prepared and dehydrocoupling catalysis afforded (Me2C6H2P(PH))(2) (18) and subsequently [(Me2C6H2P2)(2)(mu-Me2C6H2P2)](2) (19). Stoichiometric reactions with these bisphosphines gave [Cp*Zr-2(H)(PH)(2)C6H4] [Li(thf)(4)] (22), [Cp*Ti(NPtBu3)(PH)(2)C6H4](2) (23) and [Cp*Ti(NPtBu3)(PH)(2)C6H4] (24). Mechanistic implications are discussed.PT: J; CR: ALBRAND JP, 1976, J CHEM SOC CHEM COMM, P876 ANSELME JP, 1969, TETRAHEDRON, V25, P855 BASULI F, 2003, J AM CHEM SOC, V125, P10170 BAUDLER M, 1976, Z NATURFORSCH B, V31, P558 BAUDLER M, 1978, CHEM BER, V111, P1210 BAUDLER M, 1978, CHEM BER, V111, P1217 BAUDLER M, 1983, CHEM BER, V116, P2711 BAUDLER M, 1984, Z NATURFORSCH B, V39, P438 BAZAN GC, 1991, J AM CHEM SOC, V113, P6899 BOHM VPW, 2001, ANGEW CHEM, V113, P4832 CHAUVIN Y, 1971, MAKROMOL CHEM, V141, P161 COREY JY, 2004, ADV ORGANOMET CHEM, V51, P1 COURET C, 1986, ORGANOMETALLICS, V5, P113 COWLEY AH, 1984, TETRAHEDRON LETT, V25, P2125 COWLEY AH, 1990, INORG SYNTH, V27, P235 CROMER DT, 1974, INT TABLES CRYSTALLO, V4, P71 ETKIN N, 1997, J AM CHEM SOC, V119, P11420 ETKIN N, 1997, J AM CHEM SOC, V119, P2954 ETKIN N, 1997, ORGANOMETALLICS, V16, P3504 FEHLNER TP, 1992, INORGANOMETALLLICS FERMIN MC, 1995, J AM CHEM SOC, V117, P12645 FERMIN MC, 1995, ORGANOMETALLICS, V14, P4247 FU GC, 1993, J AM CHEM SOC, V115, P9856 GAUVIN F, 1998, ADV ORGANOMET CHEM, V42, P363 GRAHAM TW, 2004, ORGANOMETALLICS, V23, P3309 GRUBBS RH, 1972, J AM CHEM SOC, V94, P2538 GRUBBS RH, 2003, HDB METATHESIS HEY E, 1988, CHEM BER, V121, P561 HEY E, 1989, J ORGANOMET CHEM, V378, P375 HO JW, 1991, ORGANOMETALLICS, V10, P3001 HO JW, 1994, INORG CHEM, V33, P865 HOFFMAN PR, 1975, INORG CHEM, V14, P1997 HOSKIN AJ, 2001, ANGEW CHEM, V113, P1917 HOU ZM, 1993, ORGANOMETALLICS, V12, P3158 INAGAKI Y, 1980, B CHEM SOC JPN, V53, P205 ISSLEIB K, 1972, ANGEW CHEM, V84, P582 ISSLEIB K, 1987, J ORGANOMET CHEM, V330, P17 JACOBSEN EN, 1988, J AM CHEM SOC, V110, P1968 KATSUKI T, 1980, J AM CHEM SOC, V102, P5974 KAUFFMANN T, 1984, TETRAHEDRON LETT, V25, P1963 KAUFFMANN T, 1985, CHEM BER, V118, P1022 KITAMURA M, 1988, J AM CHEM SOC, V110, P629 KNOWLES WS, 1983, ACCOUNTS CHEM RES, V16, P106 KOEPF H, 1981, CHEM BER, V114, P2731 KOHLER EP, 1935, J AM CHEM SOC, V57, P367 KYBA EP, 1983, ORGANOMETALLICS, V2, P1877 MILLER AR, 1976, J AM CHEM SOC, V98, P1860 MILLER SJ, 1996, J AM CHEM SOC, V118, P9606 MIYASHITA A, 1980, J AM CHEM SOC, V102, P7932 MURDZEK JS, 1987, ORGANOMETALLICS, V6, P1373 NGUYEN ST, 1992, J AM CHEM SOC, V114, P3974 NGUYEN ST, 1993, J AM CHEM SOC, V115, P9858 NOVAK BM, 1988, J AM CHEM SOC, V110, P960 OHKUMA T, 1995, J AM CHEM SOC, V117, P2675 OHTA T, 1988, INORG CHEM, V27, P566 OSHIKAWA T, 1985, CHEM IND-LONDON, P126 ROCKLAGE SM, 1981, J AM CHEM SOC, V103, P1440 SCHOLL M, 1999, TETRAHEDRON LETT, V40, P2247 SCHROCK RR, 1974, J AM CHEM SOC, V96, P6796 SCHROCK RR, 1980, J MOL CATAL, V8, P73 SCHROCK RR, 1988, J MOL CATAL, V46, P243 SCHROCK RR, 1990, J AM CHEM SOC, V112, P3875 SCHWAB P, 1995, ANGEW CHEM INT EDIT, V34, P2039 SCHWAB P, 1995, ANGEW CHEM, V107, P2179 SCHWAB P, 1996, J AM CHEM SOC, V118, P100 SENDERIKHIN AI, 1988, ZH OBSHCH KHIM+, V58, P1662 SENDERIKHIN AI, 1989, ZH OBSHCH KHIM+, V59, P2141 SEYFERTH D, 1969, J ORG CHEM, V34, P1483 SHELDRICK GM, 2000, SHELXTL SHU RH, 1998, J AM CHEM SOC, V120, P12988 SMIT CN, 1983, TETRAHEDRON LETT, V24, P2031 SOUFFLET JP, 1973, CR ACAD SCI C CHIM, V276, P169 STEPHAN DW, 2000, ANGEW CHEM, V112, P322 STEPHAN DW, 2005, ORGANOMETALLICS, V24, P2548 STRADIOTTO M, 2001, HELV CHIM ACTA, V84, P2958 TILLEY TD, 1990, COMMENTS INORG CHEM, V10, P37 TILLEY TD, 1993, ACCOUNTS CHEM RES, V26, P22 TVERDOMED SN, 2003, RUSS J GEN CHEM+, V73, P319 VANDENWINKEL Y, 1991, J ORGANOMET CHEM, V405, P183 WATERMAN R, 2006, ANGEW CHEM INT EDIT, V45, P2926 WATERMAN R, 2006, ANGEW CHEM, V118, P2992 WEAST RC, 1974, HDB CHEM PHYS, P2436 WOOD CD, 1979, J AM CHEM SOC, V101, P3210 WU Z, 1995, J AM CHEM SOC, V117, P5503 XIN SX, 1997, J AM CHEM SOC, V119, P5307; NR: 85; TC: 0; J9: CHEM-EUR J; PG: 12; GA: 113PJSource type: Electronic(1
Hybrid Modelling and Simulation (M&S): Driving Innovation in the Theory and Practice of M&S
No full textThis is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordHybrid Simulation (HS) is the application of two or more simulation techniques (e.g., ABS, DES, SD) in a
single M&S study. Distinct from HS, Hybrid Modelling (HM) is defined as the combined application of
simulation approaches (including HS) with methods and techniques from the broader OR/MS literature and
also across disciplines. In this paper, we expand on the unified conceptual representation and classification
of hybrid M&S, which includes both HS (Model Types A-C), hybrid OR/MS models (D, D.1) and crossdisciplinary hybrid models (Type E), and assess their innovation potential. We argue that model types
associated with HM (D, D.1, E), with its focus on OR/MS and cross-disciplinary research, are particularly
well-placed in driving innovation in the theory and practice of M&S. Application of these innovative HM
methodologies will lead to innovation in the application space as new approaches in stakeholder
engagement, conceptual modelling, system representation, V&V, experimentation, etc. are identified
Auditory cortical activity in synchronized and desynchronized states
No full textCortical information processing depends critically on an animal’s brain state. Previous research has revealed there is a great deal of variability in cortical responses to repeated stimuli. This thesis addresses the question of whether activity and response variability in rat auditory cortex depends on brain state. Specifically, we hypothesized that both spontaneous and evoked activity differ between states; furthermore that cortical responses in higher-frequency “desynchronized” EEG states would be less variable and follow sensory input up to higher temporal modulation frequencies. We first assessed the spontaneous activity of auditory cortex during silence. During synchronized “slow wave” EEG states the spike counts of individual neurons in sequential time bins were irregular, but this irregular firing was coordinated across the neural population. Spike counts were more regular following a tail pinch-induced shift to higher-frequency EEG, and the population-wide coordination disappeared. We also uncovered a set of high-firing neurons with independent, rhythmic activity during desynchronized states, peaking between 8 to 18 Hz. Next we characterized responses to loud single-click stimuli. Many neurons discharged short-latency spikes with similar latency across states. These preserved spike latencies manifested as brief, sub-50ms population sequences of activity with similar profiles in different brain states. In some experiments we observed late, long-lasting effect of clicks on firing rates in synchronized states. In our last study, we show that evoked local field potentials (LFPs) can follow high-frequency amplitude modulations of broadband noise during desynchronized regimes. Spikes also track input more reliably and can be better predicted from stimuli in desynchronized states than in slow-wave states. Finally, we address whether LFPs reliably predict neural activity, and show that in most cases LFPs explain more spiking variability than our amplitude-modulated white noise stimuli. Thus much ‘noise’ in neural responses is not cell-specific, but reflects a source shared across many cells; such variability is state-dependent, and can be accounted for by LFP dynamics. Our first studies demonstrate that despite clear changes in spontaneous activity, strong onset responses to discrete broadband stimuli are often preserved across states. The final study suggests the desynchronized state supports improved representation of temporally modulated stimuli in auditory cortex.Ph.D.Includes bibliographical referencesIncludes vitaby Stephan L. Margue
Corresponding author
No full textComparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria Stephan Karl 1,2,3,4*,
Recognition by forensic facial approximation: Case specific examples and empirical tests
No full textCopyright © 2005 Elsevier Ireland Ltd All rights reserved.The skeletal remains of one individual found near Adelaide in 1994, although not known at the time, were the first evidence of what was to be a serial killing reported to have resulted in the highest casualty list to date in Australia (12 victims). Since the usual methods of identification could not be used or were unsuccessful on these remains, facial approximations were produced and advertised over the 4-year period following their discovery, in an attempt to help to identify them. However, no identification was made. In 1999, the remains were reported to be identified by radiographic comparison. Approximately 3 months before this identification was made, another facial approximation was produced by the first author (CNS), but this face was never advertised in the media. Although rarely reported in the literature, this paper provides an example where facial approximation methods were not successful in a forensic scenario. The paper also reports on empirical tests of the facial approximation created by the first author to determine if this facial approximation might have been useful had it been advertised. The results provide further evidence that high resemblance of a facial approximation to the target individual does not indicate recognizability, as the facial approximation was poorly recognized even though it bore good resemblance to the target individual. The usefulness of facial approximation techniques is discussed within the context of this case and more broadly. Methods used to assess the accuracy of facial approximations are also discussed and further evaluated.C.N. Stephan and M. Henneberghttp://www.elsevier.com/wps/find/journaldescription.cws_home/505512/description#descriptio
- …
