343,385 research outputs found
Allo stato puro; Tiziana Priori. Meditazioni per Gea; Armanda Verdirame. Sedimentazioni
No full textSi tratta di tre testi pubblicati nel volume "Tiziana Priori & Armanda Verdirame. Allo stato puro": una presentazione comune e un testo dedicato a ciascuna artista
European Society of Cardiology Congress 2019 Together With the World Congress of Cardiology in Paris: The Scientific Chairs Give the Inside Track on Achieving Excellence and Engagement
No full textHow do you attract 33 500 people from around the world to a cardiovascular conference? Offer plenty of important new science. That was the recipe for the European Society of Cardiology (ESC) and its Congress 2019, held in Paris over 5 days this summer. Chairing the Program Committee of any congress is challenging enough, but organizing the Scientific Program of the world’s largest cardiovascular congress is a daunting task. This year, ESC President Professor Barbara Casadei appointed 2 chairs: Professor Silvia Priori and Professor Marco Roff
On adaptive sliding mode control without a priori bounded uncertainty
No full textAdaptive Sliding Mode Control (ASMC) aims to adapt the switching gain in such a way to cope with possibly unknown uncertainty. In state-of-the-art ASMC methods, a priori boundedness of the uncertainty is crucial to ensure boundedness for the switching gain and uniformly ultimately boundedness. A priori bounded uncertainty might impose a priori bounds on the system state before obtaining closed-loop stability. A design removing this assumption is still missing in literature. A positive answer to this quest is given by this note where a novel ASMC methodology is proposed which does not require a priori bounded uncertainty. An illustrative example is presented to highlight the main features of the approach, after which a general class of Euler–Lagrange systems is taken as a case study to show the applicability of the proposed design.Accepted Author ManuscriptShip Design, Production and OperationsTeam Bart De Schutte
Fast GMTI Algorithm For Traffic Monitoring Based On A Priori Knowledge
No full textIn this paper a fast a priori knowledge-based ground moving target indication and parameter estimation algorithm applicable to single- as well as to multi-channel synthetic aperture airborne radar data is presented. The algorithm operates directly on range-compressed data. Only the intersection points of the moving vehicle signals with the a priori known road axes, which are mapped into the range-compressed data array, are evaluated. For moving vehicle detection and parameter estimation for each considered road point basically only one single FFT has to be performed. Hence, the required computational power is low and the algorithm is well suited for real-time traffic monitoring applications. The proposed algorithm enables the estimation of the whole position and velocity vectors of the detected moving vehicles, even if only a single-channel synthetic aperture radar system is used
A priori and a posteriori analysis of the quasinonlocal quasicontinuum method in 1D
No full textFor a next-nearest neighbour pair interaction model in a periodic domain, a priori and a posteriori analyses of the quasinonlocal quasicontinuum method (QNL-QC) are presented. The results are valid for large deformations and essentially guarantee a one-to-one correspondence between atomistic solutions and QNL-QC solutions. The analysis is based on consistency error estimates in negative norms, novel a priori and a posteriori stability estimates, and a quantitative inverse function theorem
A priori error analysis of two force-based atomistic/continuum models of a periodic chain
No full textThe force-based quasicontinuum (QCF) approximation is a non-conservative atomistic/continuum hybrid model for the simulation of defects in crystals. We present an a priori error analysis of the QCF method, applied to a one-dimensional periodic chain, that is valid for an arbitrary interaction range, large deformations, and takes coarse-graining into account. Our main tool in this analysis is a new concept of atomistic stress. Moreover, we formulate a new atomistic/continuum coupling mechanism based on coupling stresses instead of forces and extend the a priori analysis to this new method. We show that the new method has several theoretical advantages over the original QCF method
Benefit of Implantable Cardioverter-Defibrillators in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia - Reply
No full textIn Reply: We thank Maass and Cox for their comment on our work,1 and for stimulating the discussion on the role of implantable cardioverter-defibrillators (ICDs) in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT).
In our cohort, we did not observe an excess of crude mortality rates in ICD carriers (0.15 per 100 person-years) compared with noncarriers (0.56 per 100 person-years; P = .38). Considering that in this relatively young population, the dominant contributor to mortality is sudden cardiac death, we assessed the likelihood of survival at the occurrence of the first life-threatening arrhythmic event (LTAE; composite of sudden cardiac death, aborted cardiac arrest, or hemodynamically nontolerated sustained ventricular tachycardia), a previously validated hard end point.2,3 Our data show that patients without an ICD were 25-fold more likely to die at the occurrence of the first LTAE compared with ICD carriers, supporting the conclusion that ICD confers a survival benefit in high-risk patients with CPVT.1 However, when discussing the benefits and drawbacks of ICD, mortality should not be the only factor considered, since patients without an ICD may survive an out-of-hospital cardiac arrest with neurological disability secondary to anoxic brain injury, as in the case of 2 of 6 patients without an ICD who survived a cardiac arrest in our cohort.
We agree with the authors that appropriate ICD shocks are not always necessary, especially on self-terminating arrhythmias. We acknowledge that a typographic mistake occurred during the editing of the article, and the sentence cited by the authors regarding the episodes terminated by the ICD should read, “Overall, all 15 episodes of VF [ventricular fibrillation] were successfully interrupted, while only 3 of 6 episodes (50%) of hemodynamically unstable, polymorphic fast VT [ventricular tachycardia] were terminated (P < .001).”4 We thank the authors for giving us the opportunity to clarify that the majority of ICD shocks on LTAE occurred on ventricular fibrillation, which are known to not cease spontaneously. This is also explained by our long-standing collaboration with Maurizio Gasparini, MD, which led to us to adopt into our clinical practice ICD programming with a long detection to deliver a shock only on ventricular fibrillation, a strategy demonstrated to reduce the rate of both appropriate and inappropriate shocks without differences in mortality.5 Regarding the 3 of 6 shocks (50%) on polymorphic VT that failed to terminate the arrhythmia, this is not surprising, since it is known that substrate (and arrhythmia mechanism) is a potent predictor of shock efficacy.6
Lastly, neither flecainide nor verapamil nor left cardiac sympathetic denervation have been demonstrated to reduce mortality in patients with CPVT at the time of the publication of this work. Considering that the practice of modern medicine should be based on the best evidence available, at the present time, these therapies cannot represent an alternative for ICD
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