4,304 research outputs found
JH-induced phosphorylation of aPKC and Par3 as well as zonula adherens disassembly.
No full text(A) The levels of phosphorylated aPKC (p-aPKC) and Par3 (p-Par3) in the follicular epithelium of adult females during the first gonadotropic cycle. (B) Phosphorylation of aPKC and Par3 in cultured follicular epithelia of 7-day-old females treated by JH at 0.1 μM for 5–30 min. (C) Suppression of ACPD on JH-induced aPKC and Par3 phosphorylation in cultured follicle cells of 7-day-old females. ACPD was applied at 0.1 μM prior to JH treatment. (D) Distribution of p-aPKC in cultured follicular epithelium from adult females on day 8 and treated with DMSO, JH and ACPD+JH, respectively. Blue: nuclei. Green: F-actin. Arrow heads indicate patency. Scale bars: 5 μm. (E) Distribution of p-Par3 in cultured follicular epithelia from adult females on day 8 and treated with DMSO, JH and ACPD+JH, respectively. Arrow heads indicate patency. Scale bars: 5 μm. (F) Immunoprecipitation (IP) and Western blotting (WB) showing inhibition of ACPD on JH-induced disassociation of p-Par3 and β-Cat. (G) Distribution of β-Cat in the follicular epithelium treated with DMSO, JH and ACPD+JH. Arrow heads indicate patency. Scale bars: 5 μm.</p
Prior upper body exercise reduces cycling work capacity but not critical power
No full textPurpose: This study examined whether metabolite accumulation, induced by prior upper body exercise, affected the power–duration relationship for leg cycle ergometry
On co-authorship for author disambiguation
No full textAuthor name disambiguation deals with clustering the same-name authors into different individuals. To attack the problem, many studies have employed a variety of disambiguation features such as coauthors, titles of papers/publications, topics of articles, emails/affiliations, etc. Among these, co-authorship is the most easily accessible and influential, since inter-person acquaintances represented by co-authorship could discriminate the identities of authors more clearly than other features. This study attempts to explore the net effects of co-authorship on author clustering in bibliographic data. First, to handle the shortage of explicit coauthors listed in known citations, a web-assisted technique of acquiring implicit coauthors of the target author to be disambiguated is proposed. Then, a coauthor disambiguation hypothesis that the identity of an author can be determined by his/her coauthors is examined and confirmed through a variety of author disambiguation experiments. (C) 2008 Elsevier Ltd. All rights reserved.X1174sciescopu
Bilateral and unilateral arm training improve motor function through differing neuroplastic mechanisms: a single-blinded randomized controlled trial
No full textBACKGROUND AND PURPOSE:
This randomized controlled trial tests the efficacy of bilateral arm training with rhythmic auditory cueing (BATRAC) versus dose-matched therapeutic exercises (DMTEs) on upper-extremity (UE) function in stroke survivors and uses functional magnetic resonance imaging (fMRI) to examine effects on cortical reorganization.
METHODS:
A total of 111 adults with chronic UE paresis were randomized to 6 weeks (3×/week) of BATRAC or DMTE. Primary end points of UE assessments of Fugl-Meyer UE Test (FM) and modified Wolf Motor Function Test Time (WT) were performed 6 weeks prior to and at baseline, after training, and 4 months later. Pretraining and posttraining, fMRI for UE movement was evaluated in 17 BATRAC and 21 DMTE participants.
RESULTS:
The improvements in UE function (BATRAC: FM Δ = 1.1 + 0.5, P = .03; WT Δ = -2.6 + 0.8, P < .00; DMTE: FM Δ = 1.9 + 0.4, P < .00; WT Δ = -1.6 + 0.7; P = .04) were comparable between groups and retained after 4 months. Satisfaction was higher after BATRAC than DMTE (P = .003). BATRAC led to significantly higher increase in activation in ipsilesional precentral, anterior cingulate and postcentral gyri, and supplementary motor area and contralesional superior frontal gyrus (P < .05). Activation change in the latter was correlated with improvement in the WMFT (P = .01).
CONCLUSIONS:
BATRAC is not superior to DMTE, but both rehabilitation programs durably improve motor function for individuals with chronic UE hemiparesis and with varied deficit severity. Adaptations in brain activation are greater after BATRAC than DMTE, suggesting that given similar benefits to motor function, these therapies operate through different mechanisms
The distance-regular graphs such that all of its second largest local eigenvalues are at most one
No full textIn this paper, we classify distance-regular graphs such that all of its second largest local eigenvalues are at most one. Also we discuss the consequences for the smallest eigenvalue of a distance-regular graph. These extend a result by the first author, who classified the distance-regular graphs with smallest eigenvalue -1 - b(1)/2. (C) 2011 Elsevier Inc. All rights reserved.X1154sciescopu
Ambiguity distance: an edge evaluation measure using fuzziness of edges
No full textMost edge detection methods have parameters (threshold values or standard deviation of Gaussian operator for smoothing) to be set, and these parameters make much influence on the outputs of the detectors. In this paper we propose an objective parameter evaluation measure. We evaluate parameters based on the edge ambiguity measures of existence, location and formation. The existence and location ambiguity measures are derived from comparing fuzzy memberships of edgeness with detected edges, and the formation ambiguity measure assesses the connectedness and the total number of edge point in an edge image with respect to the image size. The parameters which produce the least ambiguous edges of a detection method for an image are selected as significant ones. No iterative visual interaction or prior knowledge of edges are needed for these evaluation measures, The effectiveness of the measures is demonstrated by applying the ambiguity measures to synthetic and real images. (C) 2002 Elsevier Science B.V. All rights reserved.X113sciescopu
On geometric distance-regular graphs with diameter three
No full textIn this paper we study distance-regular graphs with intersection array {(t + 1)s. ts. (t - 1)(s + 1 - psi); 1, 2, (t + 1)psi} (1) where s. t. psi are integers satisfying t >= 2 and 1 = 2, there are only finitely many distance-regular graphs of order (s, t) with mallest eigenvalue -t -1, diameter D = 3 and intersection number c(2) = 2 except for Hamming graphs with diameter three. Moreover, we will show that if a distance-regular graph with intersection array (1) for t = 2 exists then (s, psi) = (15, 9). As Gavrilyuk and Makhnev (2013)[9] proved that the case (s, psi) = (15, 9) does not exist, this enables us to finish the classification of geometric distance-regular graphs with smallest eigenvalue -3, diameter D >= 3 and c(2) >= 2 which was started by the first author (Bang, 2013)[1]. (C) 2013 Elsevier Ltd. All rights reserved.X1121Ysciescopu
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