1,720,991 research outputs found
Long-term narrowband UVB phototherapy in vitiligo: Good results are correlated with a long period of continuous and constant therapy
No full textAim. The treatment of vitiligo remains a challenge. In literature various treatment modalities have been proposed. In the present study a long-term narrowband UVB (UVB-NB) approach to vitiligo is proposed in 25 patients. Methods. Treatment frequency was twice a week, on 2 non-consecutive days; treatment was continued for 1 year or discontinued earlier, in case of satisfactory or even complete repigmentation. Photographs of the body surface interested by vitiligo were taken before, during and after treatment; phototherapy responses were expressed as more than 75% repigmentation (group A); between 26% and 75% repigmentation (group B); less than 25% repigmentation (group C) and not responders (group D). Results. At the end of the study (12 months), 11 patients (44%) showed an excellent repigmentation (group A); 8 patients (32%) had a satisfactory good repigmentation (group B); 2 patients (8%) had an unsatisfactory response (group C), and 4 patients (16%) were not responders (group D). The best response was achieved by those patients who had recent vitiligo (100% of patients in group A and 70% of patients in group B). Conclusion. This study suggests that UVB-NB therapy represents a valuable and safe option for vitiligo and confirms that good results are correlated with a long period of continuous therapy; moreover, further improvement could be observed when UVB-NB therapy was prolonged till the end of the first year of treatment or more
Narrow-band ultraviolet therapy in early-stage mycosis fungoides: study on 20 patients
No full textBackground: In recent years, narrow-band ultraviolet B (NB-UVB, 311-313 nm) has been found to be beneficial for early-stages mycosis fungoides (MF). The aim of this study is to investigate the effect of NB-UVB in 20 patients with early-stage MF.
Methods: Twenty patients ( 10 women and 10 men, mean age 54 +/- 22 years) with clinically and histologically confirmed MF were enrolled in the study. All of the patients had clinical stage I disease (T1 or T2, N0, M0) with cutaneous involvement, consisting of patchstage disease of limited extent, in 50% of the cases (stage IA), and more widespread in the other 50% (stage IB). All the patients were treated with NB-UVB therapy until more than 95% clearance of the patient's skin lesions had occurred.
Results: A complete response was achieved in 90% of the cases after a mean of 29 +/- 14 treatments within a mean period of 4 months (range 1-8 months), with an average cumulative dose of 25 +/- 16.77 J/cm(2). In the follow-up period, relapse occurred after a mean period of 8 months (range 3-17 months), and then therapy was restarted.
Conclusion: This study provides evidence that NB-UVB might be an efficient option for stage IA and IB MF patients
Self-involuting atrophoderma of the lateral-upper arm: A new name or an old pathology?
No full textSelf-involuting atrophoderma of the lateral-upper arm (SALA) is a dermatosis characterized by slightly atrophic patches on arms, with spontaneous resolution. According to Japanese authors, this is a new variety of a self-healing limited collagen disease. The case of a 40-year-old female, presenting a slightly atrophic patch of 10 cm in diameter on the left arm and a brown patch on the right thigh, is described. No other cutaneous changes were present. Personal and familiar history were negative for dermatologic diseases. Laboratory studies were in the normal range or negative. Histologic examination of a punch biopsy on the arm was characterized by sparse lymphocytic infiltrate in the upper, mid- and deep dermis as well as slight thickening of collagen bundles in upper dermis. The epidermis was slightly atrophic. Within four months, the cutaneous lesions disappeared spontaneously. Self-involuting atrophoderma of the lateral-upper arm (SALA), first described by Inazumi et al., in 1997, may represent, as in this case, a benign superficial form of morphea. Similarities of SALA, atrophoderma of Pasini-Pierini and localized morphea are discussed, and the conclusion that SALA, atrophoderma of Pasini-Pierini and this case may belong to the same spectrum of localized morphea is presented
Keratoacanthoma in vitiligo lesion after UVB narrowband phototherapy.
No full textThe treatment of vitiligo is still a challenge. Among various therapeutic modalities, phototherapy with UVB narrowband (UVB-NB) is presently considered a treatment of choice for this skin disease.
The exact skin cancer risk deriving from UVB-NB is a serious concern to be determined. We report a case of keratoacanthoma developed in the vitiligo area during a prolonged course of UVB-NB therapy
HIV seronegative eosinophilic pustular folliculitis successfully treated with doxicycline.
No full textEosinophilic pustular folliculitis (EPF) is an unusual disease, first described in adult East Asians in 1970 by Ofuji. It is characterized by follicular papules and pustules tending to coalesce and form plaques involving the trunk, face and extremities. In recent years, it has been often associated with human immunodeficiency virus (HfV) infection or with immunosuppressed and/or oncohaematological patients. EPF has been described in immunocompetent adult caucasian patients only occasionally. The diagnosis requires clinical and microbiological features such as sterile folliculitis and histopathological findings characterized by folliculitis and perifolliculitis with eosinophilic infiltrate. We describe an HfV seronegative caucasian male with EPF, allergic to non-steroidal anti-inflammatory drugs and indomethacin, treated with oral doxicycline. The treatment led to the complete remission of the lesions within 2 months
Sequential treatment of severe atopic dermatitis with cyclosporin A and low-dose narrow-band UVB phototherapy.
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Atrofodermia autorisolvente degli arti superiori: un nome nuovo per una vecchia malattia?
No full textÈ stata recentemente descritta in Letteratura una dermatosi caratterizzata da chiazze leggermente atrofiche, localizzate agli arti superiori, che risolvono spontaneamente, senza esiti cicatriziali, nell’arco di qualche mese. Secondo questi Autori giapponesi, tali lesioni rappresenterebbero una nuova variante di morfea, conosciuta sotto l’acronimo di SALA (“Self involuting Atrophoderma of the Lateral-upper Arm”).
Descriviamo il caso di una paziente di 40 anni, che da qualche mese presentava una chiazza leggermente atrofica, di circa 10 cm di diametro, localizzata al braccio sinistro ed una seconda lesione non atrofica di colore brunastro alla coscia destra.
La paziente non presentava altre lesioni cutanee. L’anamnesi patologica remota dermatologica e familiare erano negative.
Abbiamo eseguito una biopsia cutanea per esame istologico. Il quadro istopatologico era caratterizzato dalla presenza di uno scarso, se non assente infiltrato infiammatorio linfocitario, e da lieve ispessimento delle fibre collagene nel derma superficiale. L’epidermide presentava modesta atrofia. Dopo 4 mesi dalla prima osservazione, le lesioni erano scomparse.
Nel 1999 McNiff et al. descrissero 6 casi di morfea con alterazioni istologiche limitate al derma superficiale e caratterizzate solo da ispessimento dei fasci di fibre collagene. Si trattava di una variante rara di morfea clinicamente caratterizzata da uno scarso indurimento cutaneo. Una revisione critica della Letteratura ci ha portato alla conclusione che questa «nuova» entità SALA sia assimilabile ad una morfea superficiale a risoluzione spontanea
Non-invasive evaluation of tacalcitol plus puva versus tacalcitol plus UVB-NB in the treatment of psoriasis: "right-left intra-individual pre/post comparison design".
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