3,121 research outputs found
The Prentice-O'Gorman destination appraisal matrix: Iranian case study
No full textPrentice's model was designed to challenge a tendency in contemporary destination marketing to emphasise SSPs (Standardised Selling Points) rather than USPs (Unique (or at least Unusual) Selling Points). This process of standardisation is what the French have termed Banalisation (Prentice 2006b). Prentice's model is a hybrid of traditional destination choice sets models (Crompton 1992; Sirakaya and Woodside 2005) with inputs from the Theory of Reasoned Action (Aizen and Fishbein 1980) and from heuristic choice models (Pham 1998). Prentice further differentiates USPs into UUSPs (Unique Utility Selling Points) UESPs (Unique Experiential Selling Points) USSPs (Unique Symbolic Selling Points). These may be thought of as summarising those aspects of generic imagery and product beliefs that are pertinent to destination differentiation. As specified, Prentice's model is a model of choosing on the part of potential tourists. The question arises as to how destination managers may readily operationalise Prentice's ideas in both their marketing and market based product development or, indeed, simply to think about their destination. Many managers are familiar with SWOT analysis and the operationalisation of Prentice's ideas suggested here builds on this familiarity. The demonstrated means of application is in the form of a matrix combining Prentice's expansion of USPs with a traditional SWOT analysis
p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies
No full textThe p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (CLL) cells. Abnormalities within the p53 pathway identify a subset of patients with a poor prognosis. This review describes recent advances in understanding the mechanisms that regulate p53 levels and the role of p53 in the control of the cell cycle and of apoptosis. The classical model of p53-mediated apoptosis emphasizes the transcriptional activation of proapoptotic genes. In contrast, a novel model emphasizes p53's non-transcriptional actions as the major route of apoptosis induction, whereas its transcriptional arm predominantly upregulates antiapoptotic genes, thus providing a negative feedback mechanism that limits apoptosis. Further studies have identified the Notch pathway as a candidate p53-induced antiapoptotic mechanism. In contrast to the classical model, the novel model predicts that pharmacological inhibition of p53's transcriptional function or of the Notch signaling pathway will augment apoptosis induction by cytotoxic agents. Therapeutic strategies based on the novel model, which we review here for the first time, may significantly augment the antitumor actions of cytotoxic agents in CLL and in other malignancie
Review of Historical Events (pg.7)
No full textDr. A.G. Rudovic's description of the history of the Red Army invasions of Latvia, Estonia and Lithuania and what occured when the Soviet Union forcebly incorporated masses of innocent people into Soviet GULAGS and Soviet laour camps by means of mass deportatio: as well as the loss of church spiritual leaders and forbidden church services.2.0 Imanta, 2.1.7 Baltic Nations, 2.1.3 Current Latvian Histopry in Europe ( Pre-Post WWII
Moscow doctor A.G. Dreytser – author of "The Notes of an Ambulance physician"
No full textWe have attempted to present the scientific biography of Alexander Grigorievich Dreytser, the author of "The Notes of an Ambulance physician" – a popular documentary work on the life of Moscow and Muscovites during the Great Patriotic War. We have reconstructed the main points of life and activities of A.G. Dreytser and discovered a number of facts in his biography related to his studying at Strasbourg University (1911–1914) and Imperial Moscow University (1915–1917), participation in the First World War and activities in 1918–1941. The analysis of the materials stored in the State Archive of the Russian Federation, the Central State Archive of the City of Moscow, the Russian State Archive of Literature and Art, as well as the personal archive of the Dreytser family, allowed us to clarify many points related to Dreytser's life and activities during the time prior to the creation of The Notes. This article is based upon the results of a comparative analysis of the texts of The Notes and A.G. Dreytser's Ph.D. dissertation "The Material on the Question of Sudden Death: According to the Data of Morgues, Moscow City Emergency Stations and the Department of Clinical Examination of the Central Polyclinic of the People's Commissariat for Health of the USSR". This article considers the hypothesis of the unity of the events that took place in Moscow during the Great Patriotic War and were described in the dissertation and The Notes. More complete historical and biographical data on A.G. Dreytser allowed us to prove the documentary nature of The Notes, expand the scope of known facts about the organisation of medicine during the war and clarify some circumstances of the history of Russian medicine as a whole
A modified Rayleigh conjecture for static problems
No full textAbstractA modified Rayleigh conjecture (MRC) in scattering theory was proposed and justified by the author [A.G. Ramm, Modified Rayleigh conjecture and applications, J. Phys. A 35 (2002) L357–L361]. The MRC allows one to develop efficient numerical algorithms for solving boundary-value problems. It gives an error estimate for solutions. In this paper the MRC is formulated and proved for static problems
The influence of steady blowing and roughness on transitional separated boundary layers
No full textThis paper presents the results of a study between two types of forcing, namely steady blowing and a tripwire, on the control of laminar separated boundary layers. The analysis focuses on the differences in the transition process between these two types of forcing. This effect will be studied using direct numerical simulation. The main differences consists in the coherent structures formed during transition and the overall kinetic energy growth
Attendants at the 1970 Alumni Reunion on tour to the Hydraulic Laboratory, Civil Engineering
No full textAttendants at the 1970 Alumni Reunion on tour to the Hydraulic Laboratory, Civil Engineering. L to R: Prof McKay, Mrs A.G. Prentice, Mrs E.B. Freeman, Mrs A. Jorss
Andries Vierlingh, Tractaet van dyckagie (eds. J. de Hullu en A.G. Verhoeven)
No full textTranscriptie uit 1920 van het manuscript van Andries Vierlingh uit 1579 over het ontwerp en de aanleg van dijken. Zijn werk is hoofdzakelijk uitgevoerd in West Brabant. De publicatie uit 1920 is later heruitgegeven door de VBKO (Vereniging van Waterbouwers)
CIM implementation in developed and developing countries
No full textImplementing integrated advanced technologies is an effective approach towards solving most problems in today’s competitive global market Computer Integrated Manufacturing (CIM) technologies are presented as a solution to manufacturing organisations which need to perform well.
This research describes the major issues and problems facing developing countnes that wish to implement CIM. In this investigation, Libya is taken as an example of a developing country, while Ireland is used as a model of a more developed country, which has already implemented components of the CIM technology in some of its industrial companies. This research demonstrates the effect of CIM technology on Irish industry by investigating the cost effectiveness of implementing CIM, reduction of the production time, reduction of the product cost and management efficiency.
To carry out this study, 267 questionnaires were distributed to manufacturing companies in Ireland in order to help establish the status of CIM within manufacturing companies, to study the effect of CIM on Irish industries. To study CIM in Libyan industries, four Libyan companies were investigated to assess the CIM level in their companies and the possibility of implementing CIM technology in Libyan companies as a developing country. The mam findings of this research are that successful implementation of CIM depends on sufficient initial and continued investment from within the country and outside. Furthermore, in order to implement CIM successfully it is vital that there is sufficient expertise and trained workers
Aquatic Substrate Library - Fitzroy River Estuary 2003
No full textMaintenance and Update Frequency: asNeededStatement: This dataset is part of the NSD Aquatic Spectral Library<b>Purpose</b><br/>Application of spectral data to plant physiology studies, geological sciences, soil sciences, limnology, oceanography and atmospheric chemistry, and other research.Record for source data hosted in the National Spectral Database (NSD) Aquatic Library<br/><br/>Citation:<br/>Dekker, A.G., Brando, V.E., Anstee, J.M., Marks, A., Phinn, S., Roelfsema, C. Scarth, P., (2005). Final Report – Fitzroy Estuary and Port Curtis Remote Sensing Tasks (FE2 and PC2). Dekker, A.G. and Phinn, S (eds), Published by the CRC for Coastal Zone, Estuary and Waterway Management, Indooroopilly, Qld, Australia.<br/><br/>For further information and instructions to access the database go to the following URL:<br/>https://cmi.ga.gov.au/data-products/dea/643/australian-national-spectral-databas
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