29 research outputs found
Increased risk of venous thromboembolism in patients with primary mediastinal large B-cell lymphoma
No full textPathogenesis of vascular complications in Cushing's syndrome
No full textAbstrAct chronic exposure to high glucocorticoid levels in cushing's syndrome (cs) is often associated with alterations in the hemostatic system and the expression of prothrombotic phenotypes. Increased frequency of both atherothrombotic and venous thromboembolic events (VtE) has been reported in patients with cs. In general, cardiovascular complications in these patients cause a five-fold increase in mortality compared to the normal population. Although numerous abnormalities in the hemostatic system have been detected in patients with cs, the underlying mechanisms of the prothrombotic state are not fully elucidated. High levels of factor VIII and von Willebrand factor, with evidence of enhanced thrombin generation and decreased fibrinolytic activity, have been documented in several studies. However, it is not clear to what extent these changes contribute to the shift of hemostatic balance towards the hypercoagulable state and expression of thrombophilic phenotypes. thrombosis is usually a multicausal disease, and all three components of the so-called Virchow triad, namely 1) vascular abnormalities and endothelial dysfunction, 2) hypercoagulability and 3) stasis, may play a variable role in the pathogenesis of the prothrombotic state in cs patients. Larger studies are needed to establish strategies for prevention of cardiovascular complications in patients with cushing's syndrome
How do you decide on hormone replacement therapy in women with risk of venous thromboembolism?
No full text
Slow Dynamic Slope method in internal combustion engine benchmarking
No full textEnlarged engine control complexity made the full-factorial steady-state testing approach extremely time consuming and hardly applicable under actual industry demands. Slow dynamic slope (SDS) method is one of many approaches with a potential for considerable testing time savings, with its own benefits and drawbacks. This paper puts in focus SDS approach and evaluates its applicability, potentials and accuracy for fast estimation of engine steady-state maps. The presented research is based on an extensive experiment conducted on a small passenger car compresion ignition engine. Being the method that uses quasi-stationary sweeping of the engine, SDS test cycle durations in the range from 120-600 seconds are used in order to test the method and draw conclusions on its applicability. It is shown that well shaped SDS testing cycle can provide a rather good estimate of the steady-state operating points very quickly, with a negligible or very small loss of accuracy. The analysis is conducted both on fast responding variables and those that are heavily influenced by process inertia. This led to some suggestions on how to form a criterion for the SDS gathered data quality evaluation and SDS testing cycle correction
A method for quick estimation of engine moment of inertia based on an experimental analysis of transient working process
No full textThis paper presents an unconventional approach in a fast estimation of the overall engine inertia based on engine testing under transient condition (acceleration and deceleration) with simultaneous in cylinder working process analysis and friction losses estimation. The presented procedure is based on a single slow dynamic slope full load engine speed sweep test which, coupled with a simple lumped-mass engine dynamometer model, provides correct overall engine inertia estimation. Compared with the more conventional approaches in deriving information on engine inertia, besides its speed and accuracy, presented procedure provides more in depth information on both engine's dynamic response and friction as a surplus
A thermodynamic work cycle simulation of a syngas-fueled engine
No full textSprovedena je simulacija radnog procesa motora SUS koji koristi sintezni gas kao gorivo u simulacionom okruženju AVL BOOST. Cilj simulacije je sticanje uvida u očekivane radne parametre motora. Studija takođe daje uvid u toplotni bilans motora koji omogućava dimenzionisanje uređaja za rekuperaciju otpadnih toplota u kogenerativnom pogonu. Jedan turbopunjeni, 6-cilindarski gasni motor čini osnovu nad kojom je sprovedena numerička studija. Za modelovanje procesa oslobađanja toplote korišćen je Vibeov model sa korelacionim parametrima koji uzimaju u obzir uticaj sastava smeše i ugla pretpaljenja na ukupno trajanje sagorevanja i oblik diferencijalnog toka oslobađanja toplote. U radu je data i jednostavna metodologija za utvrđivanje potrebne radne zapremine motora za dati protok sinteznog gasa. Dobijene vrednosti srednjeg efektivnog pritiska kao i stepena korisnosti motora su značajno manje u poređenju sa motorima koji koriste prirodni gas, ali upotreba sinteznog gasa može predstavljati zanimljivu alternativu, naročito u slučaju korišćenja kogenerativnog postrojenja.A syngas-fueled engine work cycle simulation has been conducted in the AVL BOOST environment in order to gain some insights into the expected engine performance and efficiency parameters. The study also provides the energy balance that will dictate the design of engine coolant and exhaust gas heat recuperation systems. A turbocharged six-cylinder gas engine serves as the basis on which the numerical studies have been conducted. A Vibe-based heat release model, customized to take into account the effect of excess-air ratio and ignition timing variations on the combustion duration and MFB curve shape is used to predict the heat release rate. A simple methodology for determining the total engine displacement for a given fuel production rate is also presented. The resulting brake mean effective pressure and efficiency parameters are lower than on a comparable natural gas-fueled engine but syngas is still an interesting alternative, particularly for cogeneration units
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with severe factor XII deficiency
No full textCerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is an inherited adult-onset
microangiopathy caused by missense mutations in the Notch3gene on
chromosome 19. However, common vascular risk factors may additionally
modify clinical expression and progression of the disease. The role of
various prothrombotic factors has also been implied. We report a case
of a middle-aged man with typical clinical, neuroimaging and
histological features of CADASIL, but with notably prolonged activated
partial thromboplastin time. Hematological investigations revealed
severe clotting Factor XII deficiency. This case illustrates that the
occurrence of vascular risk factors should not be overlooked in
patients with CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with severe factor XII deficiency
No full textCerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is an inherited adult-onset
microangiopathy caused by missense mutations in the Notch3gene on
chromosome 19. However, common vascular risk factors may additionally
modify clinical expression and progression of the disease. The role of
various prothrombotic factors has also been implied. We report a case
of a middle-aged man with typical clinical, neuroimaging and
histological features of CADASIL, but with notably prolonged activated
partial thromboplastin time. Hematological investigations revealed
severe clotting Factor XII deficiency. This case illustrates that the
occurrence of vascular risk factors should not be overlooked in
patients with CADASIL
