25 research outputs found
Mass deformations of the ABJM theory: the holographic free energy
No full text© 2019, The Author(s). We find a class of new supersymmetric Euclidean solutions in four-dimensional maximal gauged supergravity. The holographic dual description of these backgrounds is given by a mass-deformation of the ABJM theory with general values for the R-charges. We calculate the S 3 free energy for the supergravity backgrounds and find agreement with the supersymmetric localization calculation of the free energy in the large N limit.sponsorship: We are grateful to Daniel Z. Freedman, Friorik Freyr Gautason, Silviu S. Pufu, and Alberto Zaffaroni for interesting discussions. The work of NB is supported in part by an Odysseus grant G0F9516N from the FWO. The work of VSM is supported by a doctoral fellowship from the Fund for Scientific Research - Flanders (FWO) and in part by the European Research Council grant no. ERC-2013-CoG 616732 HoloQosmos. NB and VSM are also supported by the KU Leuven C1 grant ZKD1118 C16/16/005. KP and FR are supported in part by DOE grant DE-SC0011687. (Odysseus grant from the FWO|G0F9516N, Fund for Scientific Research - Flanders (FWO), European Research Council|ERC-2013-CoG 616732 HoloQosmos, KU Leuven C1 grant|ZKD1118 C16/16/005, DOE|DE-SC0011687)status: Publishe
Hyperlipidemia in Pregnancy: A Systematic Review of Molec-ular Alterations and Clinical Implications
No full textSystematic Revie
Management of Littre Hernia—Case Report and Systematic Review of Case Reports
No full textLittre hernia is a rare type of hernia in which a Meckel diverticulum is found in the hernia sac. Given the rare nature of this disease, little data on demographics and surgical management exists. In this article, we provide a case report of a strangulated inguinal Littre hernia and perform a systematic review of the literature. The PubMed database was searched on 5 March 2022, and all cases of Littre hernia in adults that had English abstracts or full-text were analyzed. Our primary objective was to evaluate the surgical management and outcomes of this particular type of hernia, and our secondary objectives were to assess demographic characteristics, presentation particularities, and recurrence rates. We identified 89 articles with 98 cases, including our own. Results show a high prevalence of complications described intraoperatively, with strangulation being present in up to 38.46% of patients. The laparoscopic approach was utilized in patients with femoral, inguinal, and umbilical hernias. The most commonly performed type of resection was MD resection, followed by bowel resection, while a minority of cases (5.48%) remained unresected. Mesh repair was more frequently performed in patients with MD resection. A mortality rate of 8.7% in patients who underwent bowel resection was found. A relatively high number of reports of ectopic tissue (21.21%), ulceration (12.12%), and tumors (9.09%) were found. The average follow-up was 19.5 ± 10.29 months, with no hernia recurrence. In conclusion, most cases are admitted in an emergency setting, and intestinal obstruction is frequently associated. A minimally invasive approach can be an option even for complicated hernias. MD resection or bowel resection is usually employed, depending on the extent of ischemic lesions. Patients undergoing bowel resection may be prone to worse outcomes
Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications
No full textBackground: Dyslipidemia in pregnancy presents unique clinical challenges due to its effects on maternal and fetal health. This systematic review hypothesizes that molecular alterations in lipid metabolism during pregnancy contribute to adverse pregnancy outcomes and seeks to identify the clinical implications of these changes. The rationale behind this review stems from the increased risk of complications such as preeclampsia, intrauterine growth restriction, and acute pancreatitis associated with dyslipidemia in pregnancy. The primary objective is to examine the interplay between lipid metabolism and pregnancy outcomes. Methods: To achieve this, a systematic review following PRISMA guidelines was conducted, with a comprehensive search of the PubMed database covering articles from January 2014 to June 2024. Inclusion criteria focused on studies assessing molecular alterations and clinical outcomes of dyslipidemia in pregnancy, while case reports and relevant clinical trials were analyzed to evaluate both maternal and fetal outcomes. A total of 12 studies were included in the final analysis. Results: This study provided evidence of the need for early detection and management strategies to reduce risks. The outcomes revealed significant associations between dyslipidemia and adverse maternal outcomes such as preeclampsia, gestational diabetes, and pancreatitis, as well as fetal outcomes like preterm birth and fetal distress. Conclusions: Early lipid monitoring and intervention are crucial in mitigating these risks and suggests that a multidisciplinary approach is necessary to improve maternal and fetal health in pregnancies complicated by dyslipidemia
BiFeO3 films on steel substrate prepared by the polymerized complex method
No full textEs presenta un mètode de producció de capes primes de per síntesi en fase líquida a baixa temperatur
BiFeO3 films on steel substrate prepared by the polymerized complex method
No full textEs presenta un mètode de producció de capes primes de per síntesi en fase líquida a baixa temperatur
BiFeO3 films on steel substrate prepared by the polymerized complex method
No full textEs presenta un mètode de producció de capes primes de per síntesi en fase líquida a baixa temperatur
Low anterior rectal resection; the impact of anastomotic fistula on incidence and severity of low anterior resection syndrome
No full textObjectives. Low anterior resection is a common surgical procedure for rectal cancer, but it is associated with a distressing complication known as Low Anterior Resection Syndrome (LARS). The incidence of LARS varies, with severe symptoms persisting in some patients even years after surgery. This study aimed to investigate the association between anastomotic leak and LARS severity in rectal cancer patients. Methods. A retrospective analysis was conducted on 100 rectal cancer patients who underwent LAR between 2017 and 2021. Patients were categorized based on LARS questionnaire responses into groups with anastomotic leakage and LARS, LARS alone, or no LARS. Various factors, including demographics, comorbidities, tumor characteristics, and surgical details, were analyzed for their association with LARS. Results. In our study, anastomotic leakage was observed in 23 patients, and 17 of them subsequently developed LARS. Male gender, age over 70, and neoadjuvant therapy were identified as risk factors for LARS. Additionally, LARS was more prevalent in patients with medium and low rectal cancers and those with a protective ostomy. Conclusion. Our findings suggest that male sex and neoadjuvant chemoradiotherapy are associated with the development of LARS in rectal cancer patients undergoing low anterior resection. The timing of stoma closure and the extent of neorectal reservoir may also impact LARS severity
Transient Polyhydramnios during Pregnancy Complicated with Gestational Diabetes Mellitus: Case Report and Systematic Review
No full textPolyhydramnios is an obstetrical condition defined as a pathological increase in the amniotic fluid and is associated with a high risk of maternal-fetal complications. Common causes of polyhydramnios include fetal anatomical and genetic abnormalities, gestational diabetes mellitus, and fetal viral infections. We present the case of a 30-year-old Caucasian woman with transient polyhydramnios associated with gestational diabetes mellitus and obstetric complications. The diagnosis was based on the ultrasound assessment of amniotic fluid volume during a common examination at 26 weeks. Two weeks prior, the patient had been diagnosed with gestational diabetes mellitus. After 4 days, the patient was examined, and the amniotic fluid index returned to normal values. At 38 weeks, the patient presented to the emergency room due to lack of fetal active movement. Ultrasound revealed polyhydramnios, the patient was admitted for severe fetal bradycardia, and fetal extraction through emergency cesarian section was performed. Six weeks after birth, the patient underwent an oral glucose tolerance test with normal values, confirming gestational diabetes mellitus. We performed a systematic review of the literature on polyhydramnios, from January 2016 to April 2022, to analyze all recent published cases and identify the most common etiological causes and important aspects related to maternal-fetal outcomes
What Is the Current Status of Research on the Impact of Digitalization in Medicine? A Bibliometric Analysis
No full textObjectives: This study conducts a bibliometric analysis to map key trends in the digitalization of medicine, a rapidly evolving field that incorporates advancements such as artificial intelligence, telemedicine, and Big Data. The analysis aims to identify the most prolific authors, highly cited works, leading countries, and contributions from research institutions, while also exploring emerging trends through keyword analysis. Methods: A dataset comprising 2606 scientific papers was retrieved from the Web of Science database. The analysis was performed using bibliometric techniques and VOSviewer software to evaluate citation patterns, author productivity, country activity, and institutional contributions. Results: The findings reveal a substantial increase in research activity on the digitalization of medicine, with notable contributions from Germany, the USA, and China. These countries host leading academic institutions actively driving the field. Keyword analysis highlights emerging trends in artificial intelligence, telemedicine, and Big Data. Extensive international collaborations further underscore the global nature of this research domain. This study provides a comprehensive overview of the evolution and current trends in the digitalization of medicine. Conclusions: It highlights the significant role of international collaboration and identifies key areas of development, offering valuable insights for future research directions in this dynamic sector
