2 research outputs found
Groundwater Recharge and Surface Runoff Modeling Response to Land Use and Land Cover Dynamics in a Mae Wong Watershed of Thailand
No full textThis study aims to develop efficient management strategies and assess the spatiotemporal dynamics of land use and land cover (LULC) on surface runoff modeling response dynamics for the long-term sustainability of watersheds. The soil and water assessment tool (SWAT) model was used to evaluate the LULC dynamics on GRSR in the Mae Wong Watershed (MWW) of Thailand. Using Landsat images, three different LULC maps (2011, 2021, and 2031) were created using the cellular automata markov chain (CA-Markov) model, and TerrSet 2020 geospatial monitoring and modeling software. In the overall MWW, the forestland has undergone deforestation and decreased by 2.10% of the total area and 2.72% of the total area has been transformed into agricultural lands due to human activity and population growth. The soil, LULC, weather, and the digital elevation model (DEM) were all used in the SWAT simulation procedure. To understand the groundwater recharge and surface runoff (GRSR) responses of each hydrologic response units (HRUs), the SWAT model was calibrated and verified using streamflow and the sequential uncertainty fitting (SUFI-2) technique from the SWAT calibration and uncertainty program (SWAT-CUP). The results indicate that there is a good agreement for both the calibration and validation phases of all LULC simulations. The study indicated that groundwater recharge has decreased over the last two decades while surface runoff has increased due to the forest area being converted to agricultural land. Thus, the study can support maximizing water management and strategies for systematically attaining sustainability.
Antioxidative and neuroprotective activities of peanut sprout extracts against oxidative stress in SK-N-SH cells
No full textAbstractObjectiveTo evaluate the protective effect of peanut sprout extract (PSE) against paraquat (PQ) induced SK-N-SH cells.MethodsThree groups of cells were used in the experiment, together with a fourth, control group. One group was treated with PQ, the second group was treated with PSE, and the third group was pre-treated with PSE. The control group was untreated. Cell viability and toxicity were detected by MTT assay, cellular reactive oxygen species (ROS) was detected by Muse Cell Analyzer, quantitative RT-PCR was applied to investigate the expression of SIRT1 and α-synuclein genes, and Aβ42 was detected by western blot.ResultsThe 50% effective concentration of PQ was 0.75 mmol/L. PSE had no significant cytotoxicity at a concentration of 1.5 mg/mL. In the group of cells pre-treated with PSE, cell death was significantly inhibited. In the PQ treated group, PQ was increased in the intracellular ROS in the cells. Intracellular ROS was significantly decreased in the cells treated with PSE and also those pre-treated with PSE. PSE significantly downregulated the expression of SIRT1 and α-syn genes, and it was found that PQ significantly increased β-amyloid 42 levels whereas this action was inhibited by PSE.ConclusionsPSE has neuroprotective activities against oxidative stress in SK-N-SH cells induced by PQ, suggesting that PSE is a highly promising agent in the prevention of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease
