98 research outputs found
Financial statement and Financial Analysis - An overview
No full textFinancial Information is the basis for financial planning, analysis and decision-making. It is also useful to different users who are either directly or indirectly interested in firm. Owners of firm, managers, creditors, investors, employees and tax authorities are direct users, whereas, financial analyst, researchers and trade organization are indirect users. A firm communicates financial information to these users through financial statements and report. Financial statements contain summarized information of the firm’s financial affairs organized systematically. Therefore in the present descriptive paper, the author has tried to present theoretical concepts of financial statement, financial analysis and relationship between financial analysis
A prospect of moving towards free milk quota market in Ireland – will milk quota movement follow efficiency?
No full textQuota trade in Ireland is ‘ring fenced’ to milk processors where farmers are not allowed to trade milk quota outside their designated milk processor. This ensures milk production staying within a region but has implications for the efficiency of milk production. In this paper, we simulated a free milk quota market in Ireland and compared the results with a milk quota exchange which was ring fenced to determine if the quota move from an inefficient region to a more efficient region. The results show that quota indeed follow efficiency of production when there is restriction over trade area.Milk quota trade, Irish quota market, Farm level model, Agricultural and Food Policy,
Failure Mode Effects Analysis and Design of Experiments to Sensitive and Sustainable Microwave-Aided Spectrofluorophotometric Estimation of Teneligliptin and Method's Chlor-Tox Scale and Blue Applicability Grade Index Assessment
No full textTeneligliptin hydrobromide hydrate is efficiently controls blood sugar levels while minimizing the risk of hypoglycemia. Determination of teneligliptin in commercial formulations and biological-fluids has been documented in literature using a plethora of chromatographic, spectrophotometric, and hyphenated methods and they required toxic organic solvents. But, there was no published spectrofluorophotometric technique for teneligliptin estimation. Hence, microwave-aided spectrofluorophotometric method was developed to estimate teneligliptin with using green solvents and 7-chloro-4-nitrobenzoxadiazole as a fluorescent probe. An integrated approach of white analytical chemistry and analytical quality by design was used to estimate teneligliptin in a robust, accurate, and precise manner. The failure mode effect analysis was used to identify the critical analytical method parameters and response variables. The design of experiments was used to carry forward the important analytical method parameters and response variables for response surface modeling. The proposed spectrofluorophotometric method was applied to evaluate commercially available formulations and investigate the pharmacokinetics of teneligliptin–loaded nano-carriers that was developed in-house. The fluorescent product that was derivatized using microwaves was separated and studied using mass spectrometry. After greenness and whiteness profile assessment, researchers discovered that the suggested approach to teneligliptin estimate was eco-friendly, precise, robust, rapid, economical, and easy to apply
DESIGN AND DEVELOPMENT OF FERTILIZER SPREADER MACHINE
No full text<p>India is agricultural based country. Our economy is also depends on agricultural related product. In the recent days it has been found that farmers are unable to grain more crop production by use of conventional agricultural methods.This project is based on manually fertilization process. A method is generated to spread the fertilizer over a fallow land by dropping the fertilizer over the impeller disc. The project design divided in to three level, top level, middle level, bottom level. Top level consists a solar module. Middle level consist a hopper, impeller disc, motor. The bottom level consists tires. The whole design is supported by frame and column.This project has solved the problem of traditional way of fertilization.</p>
Evaluation of skill-oriented training on enhanced syndromic case management (ESCM) of reproductive tract infections / sexually transmitted infections (RTI/STIs) of care providers from three-tier health-care system of Gujarat
No full textBackground: Enhanced syndromic case management (ESCM) deals with reproductive tract and sexually transmitted infections. Capacity building of service providers not only boosts the program but also inputs from them improve the quality of services. Objectives: To (1) identify problem areas from providers' perspectives and the gaps in knowledge and application and (2) assess the gains (if any) through pre and post-training evaluation. Materials and Methods: A total of 121 participants (medical/para medical) from various medical colleges, district/sub-district hospitals/ community health centers, and urban dispensaries across Gujarat were trained at a teaching institute. Trainings were of 2-3 days duration involving different learning methodology. Pre- and post-training evaluation were done on a designed pro forma and data were entered in MS office Excel 2007. Gains in knowledge/skills if any were assessed by comparing pre-/post-evaluation responses and applying test of significance (x2 test). Observations: Out of total 121 participants, half (60) were doctors and the rest were paramedics [staff nurse (SN) and lab technicians (LT)]. Doctors revealed significant gain in basics of reproductive tract infections (RTI) and sexually transmitted infections (STI), syndrome identification, STI/HIV co-infection, and ESCM and less gain in asymptomatic STI/ complications, vulnerability, male reproductive organs, causes of vaginal/urethral discharge, STI complications, cervical cancer screening, and limitation of syndromic management. Gain was statistically significant in basics of RTI/STI amongst adolescent in paramedics; lab technicians showed significant gain in knowledge of laboratory-related areas. Conclusion: Assessment revealed (1) poor baseline knowledge and (2) gains following training sometimes significant and other times not significant even in core areas. Quality monitoring and contents/ methodologies modification are essential for robust trainings. Gains in skills could not be assessed through this evaluation
Design of experiments and white analytical chemistry-driven green and sensitive spectrofluorimetric estimation of pregabalin in its pharmaceutical dosage forms and spiked human plasma
No full textAbstract Background Pregabalin (PGB) is a medication with anticonvulsant, analgesic and anxiolytic properties, employed in the treatment of epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal syndrome and generalized anxiety disorder. Several spectrofluorimetric techniques have been documented for the determination of PGB in pharmaceutical dosage forms. However, these published methods typically involve the use of expensive and toxic organic solvents and reagents, as well as high reaction temperatures for PGB analysis. These components pose risks to aquatic life and the environment, making them less environmentally friendly and user-friendly. A recent advancement in analytical chemistry has introduced a white analytical approach, providing an economical, eco-friendly and user-friendly method for the development of analytical procedures. Objectives Therefore, a green and sensitive spectrofluorimetric determination of PGB, guided by white analytical chemistry principles, has been conducted utilizing distilled water as an environmentally friendly solvent. Methods The establishment of the spectrofluorimetric method involved employing the design of experiments approach to ensure a robust, precise and accurate estimation of PGB. Response surface analysis and optimization of critical procedural variables and responses were carried out using the central composite design. The validation of the developed method adhered to the guidelines outlined in ICH (International Council for Harmonization) Q2 (R1) and M10. Results The established spectrofluorimetric method was utilized to determine the PGB content in commercially available formulations and human plasma samples spiked with PGB. The obtained results were in accordance with the labeled claim of PGB in the formulations. The recovery of PGB in the spiked human plasma samples ranged from 85 to 90% of the spiked amount. Conclusions The greenness profiles of the published and suggested spectrofluorimetric methods for PGB estimation were evaluated and compared using the AGREE calculator, GAPI software and ESA tool. The suggested method demonstrated sensitivity, robustness, environmental friendliness and user-friendliness
Formulation development and characterization of in-situ gel of Rizatriptan Benzoate for intranasal delivery
No full textThe present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration for brain targeting. The gel was further optimized for process and formulation parameters by using 32 factorial design. The optimized batch having the concentrations of gellan gum and HPMC E15 LV 33.83 mg and 9.6 mg respectively. Gel strength and mucoadhesive strength of the optimized formulation were found to be 32.54 sec and 2580.50 dynes/cm2 respectively. Moreover, improved in-vitro and ex-vivo release profile of in-situ gel were observed in comparison to drug solution. In a nutshell, the developed formulation holds a great promise in overcoming the limitation associated with currently marketed RIZ formulations and illustrates the potential use of ion-activated in-situ gel to administer the drug by nasal route for brain targeting.
Keywords: In-situ gel, Rizatriptan benzoate, Ion-activated, Gellan gum, HPMC E15 LV, Brain delivery, Migrain
Gain enhancement of UWB antenna using partially reflective surface
No full textAbstractThis paper proposes, a high gain, Fabry Perot cavity antenna with coplanar waveguide (CPW) fed ultra wide band (UWB) radiating element. The proposed antenna has flat edge arrow shape-based radiating element, which act as a main radiating element and responsible for UWB radiation. This UWB microstrip antenna is parasitically coupled with an array of square parasitic patches (PPs), which act as partially reflective surface. The square patches are fabricated at the bottom of inexpensive FR4 substrate and suspended in the air with the help of dielectric rods at 1.5λ0 height. High gain is obtained by resonating PPs at near close frequencies of 3.8–8.8 GHz UWB, where partially reflective surface gives almost positive reflection phase gradients. Two laboratory prototypes of antenna, one with and another without partially reflective surface are fabricated and tested. Details of the proposed antenna design and role of partially reflective surface in gain enhancement of planar CPW fed UWB antenna are described, and typical experimental results are presented and discussed.</jats:p
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