3 research outputs found
Nanodrug therapy for salmonella biofilm disruption
No full textSalmonella infections pose a significant global health threat, affecting millions of people each year. These infections can cause a range of illnesses, from mild gastroenteritis to severe systemic diseases, such as typhoid fever. Bacteria are particularly hazardous due to their ability to form biofilms, which provide a robust defense mechanism, making traditional antibiotic treatments largely ineffective. Biofilms, which are composed of bacterial cells and extracellular polymeric substances (EPSs), create a protective barrier that impedes the penetration of antibiotics, allowing bacteria to survive even under adverse conditions. The innovative use of nanomedicine therapeutics to address the persistent challenge of Salmonella biofilm infections is explored in this chapter. Various nanodrug strategies, including the use of metallic, polymeric, and lipid-based nanoparticles, have been investigated for their potential to penetrate and disrupt biofilm structures. The mechanisms by which nanoparticles enhance antibiotic delivery are also highlighted. This chapter emphasizes the role of nanotechnology in developing more effective treatments against multidrug-resistant Salmonella strains. This chapter also focuses on the urgent need for further research to find innovative solutions for combating persistent bacterial infections
Recent advances in antiviral drug delivery strategies
No full textViral infectious diseases have long posed significant challenges to public health, leading to substantial morbidity and mortality worldwide. Recent outbreaks, including those caused by coronaviruses, have highlighted the urgent need for more effective antiviral treatments. Existing therapies, while numerous, face limitations such as drug resistance, toxicity, poor bioavailability, and non-specific targeting, which hinder their effectiveness against new and emerging viruses. This review focuses on the latest advances in nanoplatform technologies designed to enhance drug solubility, provide sustained or targeted delivery, and improve the efficacy of antiviral therapies. Additionally, we explore how these technologies can be integrated with novel strategies like genetic modulation to combat viral infections more effectively. The review also discusses the potential of these innovations in addressing the challenges posed by current antiviral therapies and their implications for future clinical applications.</p
Receptor-Targeted Nanomedicine for Cancer Therapy
No full textReceptor-targeted drug delivery has been extensively explored for active targeting of therapeutic moiety in cancer treatment. In this review, we discuss the receptors that are overexpressed on tumor cells and have the potential to be targeted by nanocarrier systems for cancer treatment. We also highlight the different types of nanocarrier systems and targeting ligands that researchers have explored. Our discussion covers various therapeutic modalities, including small molecules, aptamers, peptides, antibodies, and cell-based targeting strategies, and focuses on clinical developments. Additionally, this article highlights the challenges that arise during the clinical translation of nanocarrier-based targeting strategies. It also provides future directions for improving research in the area of clinically translatable cancer-targeted therapy to improve treatment efficacy while minimizing toxicity
