1,721,002 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome
Full text linkMyeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred, inherited host genetic factors can be responsible for tuning the disease phenotypic presentation, outcome, and response to therapy. This review covered the polymorphisms that have been variably associated to MPNs, discussing them in the functional perspective of the biological pathways involved. Finally, we reviewed host genetic determinants of clonal hematopoiesis, a pre-malignant state that may anticipate overt hematologic neoplasms including MPNs
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Mechano-biological model of glioblastoma cells in response to osmotic stress
Full text linkThis work investigates the mechano-biological features of cells cultured in monolayers in response to different osmotic conditions. In-vitro experiments have been performed to quantify the long-term effects of prolonged osmotic stresses on the morphology and proliferation capacity of glioblastoma cells. The experimental results highlight that both hypotonic and hypertonic conditions affect the proliferative rate of glioblastoma cells on different cell cycle phases. Moreover, glioblastoma cells in hypertonic conditions display a flattened and elongated shape. The latter effect is explained using a nonlinear elastic model for the single cell. Due to a crossover between the free energy contributions related to the cytosol and the cytoskeletal fibers, a critical osmotic stress determines a morphological transition from a uniformly compressed to an elongated shape
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Novel role of PKC epsilon in mitotic spindle stability.
Full text linkMitosis is a highly regulated process characterized by dramatic and coordinated
morphological changes to ensure the fidelity of chromosome segregation. Missegregation
of mitotic chromosomes leads to a condition that underlies chromosomal
instability(1), which is a hallmark of cancer. In order to assure symmetry and bipolarity
of the cell division process, mitotic spindle microtubules properly segregate
mitotic chromosomes (2). Among the several isoforms of serine/threonine kinases,
PKCε is one of the best understood for its role as a transforming oncogene, and it
has been found overexpressed in different types of tumors. In 2008, Saurin and colleagues
demonstrated the involvement of PKCε in the regulation of the late stage of
mitosis (3). Through its association with 14-3-3 at the midbody, PKCε is essential for
the successful completion of cytokinesis, and the inhibition of functional PKCε-14-3-
3 complex leads to abscission failure and multinucleated phenotype in cells. In this
study, we found that PKCε is involved in mitotic spindle stability. Using fluorescence
microscopy, we found that the active form of PKCε (phosphorylated at Ser-729), colocalizes
to the centrosome in cells in metaphase, where the mitotic spindle nucleation
occurs. Furthermore, experiments of co-immunoprecipitation revealed that, when
cells are synchronized in metaphase, PKCɛ is associated to ɣ-tubulin, a member of
the tubulin superfamily localized to the microtubule organizing centers and is essential
for microtubule nucleation from centrosomes. Consequently modulation of PKCɛ
expression affects spindle stability: PKCɛ downregulation by specific shRNA results
in mitotic spindle disorganization with a reduction of the amount of centrosomal and
mitotic ɣ-Tubulin and αβ-tubulin fluorescence. Mitotic spindle formation assays using
Nocodazole, known to interfere with the polymerization of microtubules, revealed
that cells lacking PKCɛ were unable to regrow microtubules after depolymerization.
These results reveal a novel role of PKCɛ in mitotic spindle stability, which likely
determinant for genome stability
- …
