1,127 research outputs found
Use of the Cre/Lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice.
No full textPicture frame, Gracie Tallmon
No full textFrame for a (lost) picture of Gracie Tallmon, b. 1863, d. 1864, first child of Susan Tallmon\u27s parents; Also: Greeting card from Mary H. Porter
HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency.
No full textMutations of the lamin B receptor (LBR) have been shown to cause HEM dysplasia in humans and ichthyosis in mice. LBR is a bifunctional protein with both a lamin B binding and a sterol D14-reductase domain. It previously has been proposed that LBR is the primary sterol D14-reductase and that HEM dysplasia and ichthyosis are inborn errors of cholesterol synthesis. However, DHCR14 also encodes a sterol D14-reductase and could provide enzymatic redundancy with respect to cholesterol synthesis. To test the hypothesis that LBR and DHCR14 both function as sterol D14-reductases, we obtained ichthyosis mice (Lbr2/2) and disrupted Dhcr14. Heterozygous Lbr and Dhcr14 mice were intercrossed to test for a digenic phenotype. Lbr2/2, Dhcr14D4-7/D4-7 and Lbr1/2:Dhcr14D4-7/D4-7 mutant mice have distinct physical and biochemical phenotypes. Dhcr14D4-7/D4-7 mice are essentially normal, whereas Lbr1/2:Dhcr14D4-7/D4-7 mice are growth retarded and neurologically abnormal. Neither of these mutants resembles the ichthyosis mouse and biochemically, no sterol abnormalities were detected in either liver or kidney tissue. In contrast, relatively small transient elevations of D14-sterols were observed in Lbr2/2 and Dhcr14D4-7/D4-7 brain tissue, and marked elevations were seen in Lbr1/2:Dhcr14D4-7/D4-7 brain. Pathological evaluation demonstrated vacuolation and swelling of the myelin sheaths in the spinal cord of Lbr1/2:Dhcr14D4-7/D4-7 mice consistent with a demyelinating process.This was not observed in either Lbr2/2 or Dhcr14 D4-7/D4-7 mice. Our data support the conclusions that LBR and DHCR14 provide substantial enzymatic redundancy with respect to cholesterol synthesis and that HEM dysplasia and ichthyosis are laminopathies rather than inborn errors of cholesterol synthesis
China Bulletin Number 73
No full textLetter rom Harold S. Matthews, titled "China Bulletin #73," with messages of recently released missionaries, internees at Weihsien Prison Camp (Hanting, Shantung Province): Lucius Porter, Hugh Hubbard, Louise Meebol
China\u27s revolution
No full textBooklet (100 pages) compiled by Rev. and Mrs. Harry S. (Rose L.) Martin of the American Board for Congregational Foreign Missions, includes "Summary of the reports for the year May 1st, 1911 to April 30th, 1912, compiled by Rev. L. C. Porter, detailing missionary activity in northern China, including evangelistic, educational, and medical, in the context ofthe political and social changes in the country following the Chinese Revolution of the early 20th centur
Three post cards with pictures from China
No full textThree post cards: 1) A picture of the "Senior Class" of the Williams-Porter hospitals training school for nurses, Tehchow (year not stated), with note on back that was a "P.S. #2" to a letter to Minnie Case Ellis, author uncertain; 2) Postcard with picture of a Chinese boat, probably on a canal, written 10 December 1910 from Dr Susan Tallmon in Lintsing, China, to sister Clover and her husband, Dee Smith, of Berkeley, California; 3) Postcard dated 2 August 1918 from Susan Tallmon Sargent to sister Clover Smith, informing her of the Sargents\u27 arrival from China; picture may be of the Russian River in Californi
Evaluation of CAN-FD Protocol for Traffic Signalling
No full textU ovom diplomskom radu je evaluiran CAN-FD protokol u svrhu upravljanja prometnom signalizacijom. Naglasak je stavljen na ispitivanje karakteristika protokola u realnim uvjetima te je zbog toga razvijen elektronički modul koji simulira funkcionalnosti LED modula čijim kaskadiranjem se dobiva promjenjivi prometni znak veće površine. Opisane su razlike između CAN 2.0B i CAN-FD protokola te su opisane funkcije pojedinih okvira u jednom CAN-FD paketu. U poglavljima koji se tiču razvoja programske podrške je opisano kako se konfiguriraju generatori signala takta te osnovne inicijalizacije sustava, kao i verifikacija pojedinih segmenata programskog koda. Osim razvoja sklopovlja i programske podrške pokazan je i način odabira adekvatnog mikrokontrolera u smislu karakteristika, kućišta te cijene.In this master thesis author evaluated new CAN-FD communications protocol for use in controlling dynamic traffic signs. Protocol testing was done on a custom made embedded system that simulates the funcionality of a real LED module used in dynamic signs. The differences between CAN-FD and CAN2.0B and the functions are described in the third chapter. Clock configuration and system initialization are described in the chapters regarding development of a software solution for this system as well as testing individual code segments to verify their functionality. In addition to the development of hardware and software this thesis also considers the selection of an adequate microcontroller in terms of characteristics, package and price
Regulation FD: SEC Reestablishes Enforcement Capabilities over Selective Disclosure.
No full textThis Recent Development focuses on the potential effects Regulation Fair Disclosure (FD) will have on the participants in the American capital market and on the stock markets themselves. Congress and the Securities Exchange Commission (SEC) seek to achieve confidence in the integrity and fairness of the American stock market and protection of investors from fraud by promoting equal opportunities for investors. In order to maintain a competitive edge, vis-à-vis its foreign counterparts, the United States must continually refine its financial systems to maximize fairness and integrity. This Recent Development focuses on selective disclosure—allowing a limited segment of investors access to information about a company’s financial performance—along with the inability of existing securities regulations to prohibit such practices. The recently promulgated Regulation FD is a measure anticipated to reign in the disclosure of nonpublic information to a privileged few. Specific requirements within the Regulation FD are examined by the author, and the SEC intends for the Regulation FD to level the playing field for investors. Furthermore, this Recent Development addresses potential trouble areas caused by the regulation’s interplay with other securities rules and regulations. In addition to suggestions for compliance, the various touchstones of controversy such as the effects related to Regulation FD on the securities industry are also discussed. Regulation FD molds a remedy to the perceived evils of selective disclosure. Confidentiality agreements represent the SEC’s strategy for controlling selective disclosure, without expressly authorizing it. This Recent Development concludes with an assessment of the practical effects that Regulation FD will have on the securities industry and the likelihood that it is here to stay
A Millimeter-Wave Front-End for FD/FDD Transceivers Featuring an Embedded PA and an N-Path Filter Based Circulator Receiver
No full textThis work presents an ultra-compact single-antenna FD/FDD transceivers front-end. It comprises a nonreciprocal circulator, RX, and an integrated power amplifier (PA). In the proposed circulator, we devise a ring quarter-wave transmission line topology with adjusted characteristic impedances to improve TX-to-antenna insertion loss and TX-to-RX isolation. Besides, an AND-gate switching-based N-path filter is proposed to realize the circulator's nonreciprocal gyrator while acting as a mixer-first RX. Owing to the ultra-compact N-path filter structure, the circulator occupies only 0.38mm 2 core area. Over a 27.1-to-31.1GHz band, the realized front-end offers >20dB TX-to-RX isolation while its measured TX-to-antenna insertion loss is 1.7~2.2dB. The RX path tolerates the PA's blocker signal, achieving 5dBm in-band and 13dBm out-of-band B 1dB. Moreover, the PA delivers 15.15dBm peak output power with 33% drain efficiency. Our front-end prototype occupies only 0.7mm 2 , including circulator, PA, quadrature hybrid coupler LO generators, and baseband circuits.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
Half minute summary
No full textBrief report of activities at the Williams-Porter Hospitals, Tehchow, China, for the year A.D. 193
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