3,123 research outputs found
MicroRNAs as biomarkers for CNS disease
No full textFor many neurological diseases, the efficacy and outcome of treatment depend on early detection. Diagnosis is currently based on the detection of symptoms and neuroimaging abnormalities, which appear at relatively late stages in the pathogenesis. However, the underlying molecular responses to genetic and environmental insults begin much earlier and non-coding RNA networks are critically involved in these cellular regulatory mechanisms. Profiling RNA expression patterns could thus facilitate presymptomatic disease detection.Obtaining indirect readouts of pathological processes is particularly important for brain disorders because of the lack of direct access to tissue for molecular analyses. Living neurons and other CNS cells secrete microRNA and other small non-coding RNA into the extracellular space packaged in exosomes, microvesicles or lipoprotein complexes. This discovery, together with the rapidly evolving massive sequencing technologies that allow detection of virtually all RNA species from small amounts of biological material, has allowed significant progress in the use of extracellular RNA as a biomarker for CNS malignancies, neurological and psychiatric diseases. There is also recent evidence that the interactions between external stimuli and brain pathological processes may be reflected in peripheral tissues, facilitating their use as potential diagnostic markers. In this review, we explore the possibilities and challenges of using microRNA and other small RNAs as a signature for neurodegenerative and other neuropsychatric conditions
Narayanella, a new name for Narayana Subba Rao (hymenoptera : mymaridae)
No full textThe name Narayana was applied (Subba Rao, 1976) to a genus erected for the new species N. pilipes reared from the gaUs of Lagerstoemia flos reginae. Unfortunately the author overlooked the vulid and prior use of Narayana by Distant (1908). Narayana Distant was erected with rusticitatus as type-species (Issidae: Homoptera). Hence Narayana Subba Rao is a junior homonym which has to be replaced according to the rules of the International Zoological Nomenclature
SUPPLEMENT_CLINICAL – Supplemental material for L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters
No full textSupplemental material, SUPPLEMENT_CLINICAL for L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters by Pooja Chavali, Shilpa Rao, Sravya Palavalasa, Nandeesh Bevinahalli, Yasha T. C. Muthane, Nishanth Sadashiva and Vani Santosh in International Journal of Surgical Pathology</p
Sensor Selection for Angle of Arrival Estimation Based on the Two-Target Cramér-Rao Bound
No full textSensor selection is a useful method to help reduce data throughput, as well as computational, power, and hardware requirements, while still maintaining acceptable performance. Although minimizing the Cramér-Rao bound has been adopted previously for sparse sensing, it did not consider multiple targets and unknown source models. In this work, we propose to tackle the sensor selection problem for angle of arrival estimation using the worst-case Cramér-Rao bound of two uncorrelated sources. To do so, we cast the problem as a convex semi-definite program and retrieve the binary selection by randomized rounding. Through numerical examples related to a linear array, we illustrate the proposed method and show that it leads to the natural selection of elements at the edges plus the center of the linear array. This contrasts with the typical solutions obtained from minimizing the single-target Cramér-Rao bound.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Signal Processing System
Sketch Studies and Lu Yen’s Harmony
No full textThis paper introduces the various types of music manuscripts and current issues in music sketch studies. It argues that the study of musical manuscripts is not simply the direct conversion of composition processes into music analysis. Nor is it limited to the function of providing a basis for choosing performance editions. Rather, it allows the researchers to weigh and ponder on many entangled issues, such as the composer's intentions, musical influences and music trends, composition habits, manuscripts chronology order, revisions to the draft, and traces of pre-composition plans. In addition, manuscripts could be situated in the network of various cultural or historical moments, and of a variety of musical styles and trends. It can be linked to a large web of associations contributing in different ways to the production of the manuscripts. Manuscripts are deeply rooted in historical processes and are essentially open text. The diversity of the twentieth century music manuscript, both in terms of musical language and medium, also raise new issues for sketch studies. Borrowing from Philip Gossett, this paper examines three areas of manuscript studies—confirmatory, suggestive, and conceptual—to ponder on the analysis of 20th century music. From this angle, the paper analyzes the manuscripts of Taiwanese composer Lu Yan. It focuses on several diagrams of integers in the composer’s sketches. In particular the paper examines how these diagrams reflect abstract conceptualization of pitch structure and harmony language, and how they are connected to his composition, “Woodwind Quintet.” These sketches of “pitch material” illustrate the profound thinking encompassing his harmony, melody and tone row and balanced relationship of sound world.Peer reviewedPrimarily in Chinese; abstract, annotations, notes, and some references in English
A Comparison of Trichordal Relations in Milton Babbitt's String Quartet No. 2 and Elliott Carter's A Symphony for Three Orchestras
No full textPeer reviewe
The Color of Music Heritage: Chinese America in American Ultra-Modern Music
No full textThis essay considers American ultra-modern music from the vantage point of Chinese America. It argues that the interiority of this racial terrain was molded by the negotiation, mimicry, and transformation necessarily attended musical activities across racial boundaries. Cowell‘s ultra-modern composition bears witness to Asian confluence in the American musical landscape at the beginning of the century, and raises the question of musical heritage. Rejecting the typical orientalist analysis and its self-other framework, this essay explores the significance of Chinatown music, and how a sonic idea that was engendered from it found expression in the dialogical space of American ultra-modern music.Peer reviewe
Cultural Boundary and National Border: Recent Works of Tan Dun, Chen Yi, and Bright Sheng
No full textPeer reviewe
Hearing Pentatonicism Through Serialism: Integrating Different Traditions in Chinese Contemporary Music
No full textCopyright 2002, Perspectives of New Music. Used by permission. This article first appeared in Perspectives of New Music vol 40 number 2, 2002.Peer reviewed
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