1,721,004 research outputs found

    New trends of progestins treatment of endometriosis

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    The management of endometriosis with OC or progestins is generally safe, effective and well-tolerated and should constitute the first line of medical treatment in symptomatic patients who do not want to have children. Progestins, synthetic progestational agents, have been used in the management of symptomatic endometriosis both as primary therapy and as an adjunct to surgical time. A variety of oral agents have been employed in this regard and investigators have demonstrated differing degrees of benefit. The lack of a standardized instrument to evaluate painful symptoms makes comparative analysis more difficult. Concern about efficacy and side effect has pushed the research on the development of new well-tolerated drugs and to develop new administration routes to minimize general side effects. Aim of the present review is to present the results of clinical studies on new trends of progestins in the treatment of endometriosis

    Differential diagnosis of adenomyosis: The role of hysteroscopy and laparoscopy

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    Adenomyosis is defined as the heterotopic presence of endometrial mucosa (glands and stroma) abnormally implanted within myometrium with a range of clinical presentations, the most common being heavy menstrual bleeding and dysmenorrhoea; nevertheless, patients can also be asymptomatic. This review describes the state of the art of role of hysteroscopy and laparoscopy in the diagnosis of adenomyosis according to recent literature findings. Hysteroscopy offers the advantage of direct visualization of the uterine cavity, and nowadays is performed in the office. It is immediately preceded by a physical exam and a transvaginal ultrasound (TVUS) to evaluate uterine characteristics. It is offers the possibility of obtaining endometrial/myometrial biopsies under visual control. Laparoscopy is not traditionally considered a diagnostic tool for adenomyosis, but it can have a complementary role in the differential diagnosis of this insidious pathology

    Adenomyosis: a systematic review of medical treatment

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    Adenomyosis is a heterogeneous gynaecologic condition with a range of clinical presentations, the most common being heavy menstrual bleeding and dysmenorrhoea; however, patients can also be asymptomatic. Several studies support the theory that adenomyosis results from invasion of the endometrium into the myometrium, causing alterations in the junctional zone. These changes are commonly seen on imaging studies, such as transvaginal ultrasound and magnetic resonance imaging. The aim of this review is to discuss the medical approach to the management of adenomyosis symptoms, including pain and abnormal uterine bleeding. The standard treatment of adenomyosis is hysterectomy, but there is no medical therapy to treat the symptoms of adenomyosis while still allowing patients to conceive. Medical therapies using suppressive hormonal treatments, such as continuous use of oral contraceptive pills, high-dose progestins, selective oestrogen receptor modulators, selective progesterone receptor modulators, the levonorgestrel-releasing intrauterine device, aromatase inhibitors, danazol, and gonadotrophin receptor hormone agonists can temporarily induce regression of adenomyosis and improve the symptoms
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