177,353 research outputs found
Erratum to: Analysis of E-cigarette use in the 2014 Eurobarometer survey: calling out deficiencies in epidemiology methods
No full textThe article Analysis of E-cigarette use in the 2014 Eurobarometer survey: calling out deficiencies in epidemiology methods, written by Riccardo Polosa, Pasquale Caponnetto, Ray Niaura, David Abrams, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on May 5, 2017 without open access
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease
No full textAdenosine is a purine nucleoside which mediates a variety of cellular responses relevant to asthma and COPD through interaction with specific receptors. Administration of adenosine by inhalation to patients with asthma and COPD is known to cause concentration related bronchoconstriction. Responses elicited by this purine derivative in asthma and COPD should not be considered as a mere reflection of non-specific airways hyperresponsiveness. Evaluation of airways responsiveness by adenosine induced bronchoconstriction may be valuable in differentiating asthma from COPD, monitoring of anti-inflammatory treatment in asthma, surveying disease progression, and assessing disease activity in relation to allergic airways inflammation
The mechanisms, diagnosis, and management of severe asthma in adults
No full textThere has been a recent increase in the prevalence of asthma worldwide; however, the 5-10% of patients with severe disease account for a substantial proportion of the health costs. Although most asthma cases can be satisfactorily managed with a combination of anti-inflammatory drugs and bronchodilators, patients who remain symptomatic despite maximum combination treatment represent a heterogeneous group consisting of those who are under-treated or non-adherent with their prescribed medication. After excluding under-treatment and poor compliance, corticosteroid refractory asthma can be identified as a subphenotype characterised by a heightened neutrophilic airway inflammatory response in the presence or absence of eosinophils, with evidence of increased tissue injury and remodelling. Although a wide range of environmental factors such as allergens, smoking, air pollution, infection, hormones, and specific drugs can contribute to this phenotype, other features associated with changes in the airway inflammatory response should be taken into account. Aberrant communication between an injured airway epithelium and underlying mesenchyme contributes to disease chronicity and refractoriness to corticosteroids. The importance of identifying underlying causative factors and the recent introduction of novel therapeutic approaches, including the targeting of immunoglobulin E and tumour necrosis factor alpha with biological agents, emphasise the need for careful phenotyping of patients with severe disease to target improved management of the individual patient's needs
The mechanism of bradykinin-induced bronchoconstriction in asthma
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DX190540 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Archaeological research at Elaiussa Sebaste (Rough Cilicia) in 2019
No full textSi descrivono i risultati delle ricerche archeologiche recenti a Elaiussa Sebaste (Turchia), finalizzate alla ricostruzione dello sviluppo urbano dall'età ellenistica alla prima età bizantina
Recensione a R. Pera (a cura di), Il significato delle immagini. Numismatica, arte, filologia, storia. Atti del II Incontro Internazionale di Studio del Lexicon Iconographicum Numismaticae, Genova 10-12 novembre 2005, Serta Antiqua et Mediaevalia 14, Roma (Giorgio Bretschneider Editore, 2005, pp. XXVI, 536, tavole 82 b/n
No full textAnalisi e commento di contributi sull'iconografia monetale e l'interpretazione delle immagini sulle monet
Un sistema informativo integrato a supporto delle decisioni nella pianificazione e gestione della risorsa idrica a fini irrigui in agricoltura.
No full text- …
