108 research outputs found
Transferring Social Capital Across Knowledge Domains: The Case of Nanoscience and Nanotechnology
No full textNew ‘networked’ modes of innovation increasingly emphasize the need for organizations to rely on external relationships in R&D and bring in knowledge and competences from domains outside the commercial realm. This has created opportunities for individual knowledge workers to function as critical conduits of knowledge and resources across domains of knowledge that are institutionally distant but interdependent - as the science and technology - for the knowledge creation process. The present paper explores how individual researchers accumulate and transfer social capital across these domains to generate novel knowhow. We specifically focus the attention on the structural dimension of social capital. Our empirical analysis is based on a 20-year longitudinal sample of authors, inventors, and author-inventors involved in the emerging field of nanoscience and nanotechnology
"All is Good, All is One". Rabi Nachman ben Simcha o-Bratslav. His Personality and his Work.
No full text"Vše je dobré, vše je Jedno" Rabi Nachman ben Simcha mi-Braslav Osobnost a dílo "Al lis Good, All is One" Rabi Nachman Ben Simcha of-Bratslav His Personality and his Work Mgr. Tereza Krekulová My thesis deals whith one of the most fascinating and at the same time controversial figures of Hasidic movement rabbi Nahman of Bratslav whose place in the framework of Hasidic spirituality was quite unique. It purpots to depict the features of his mentality and spiritual life which had the strongest influence on his teachings and his self-reflection as the hidden tzaddik of the whole generation with strong messianic aspiration. Both of his works differ very much from the traditional genres of Hasidic literature: his homilies are marked by their enigmatic, associative style and highly complex hermeneutical structure. His stories, unlike traditional Hasidic legend which depicts the life and miraculous deeds of tzaddikim, don't take place in the Jewish surroundings and tzaddik is present in them as their author who puts his words into the mouth of fictitions heroes. My aim was to prove the essential unity of both these works which played the crucial role na Nahman's messianic strivings. The most important conclusion is that the main purpose of both his teachings and stories which he used as material garments (levushim)..."Vše je dobré, vše je Jedno" Rabi Nachman ben Simcha mi-Braslav Mgr. Tereza Krekulová Rabi Nachman ben Simcha z Braslavi (1772 Mezibož - 1810 Uman) patří k nejoriginálnějším a zároveň i nejrozporuplnějším osobnostem chasidského hnutí. Jeho jedinečnost v rámci chasidské spirituality netkví pouze v myšlenkovém obsahu jeho subjektivně, niterně psychologicky zabarveného díla s hlubokým existenciálním přesahem; svébytný byl i jeho způsob komunikace s žáky a především vnímání sebe sama jako skrytě působícího cadika generace (cadik ha-dor) se silnou mesiášskou aspirací. Obě jeho díla se zásadně liší od tradičních žánrů chasidské literatury: homilie se vyznačují nesmírně složitou kompozicí a mnohovrstevnou hermeneutickou strukturou, příběhy na rozdíl od tradiční chasidské legendy vyprávějíci o životě a zázračných skutcích cadikim, nejsou primárně spjaty s židovským prostředím a tradicí a cadik je v nich přítomen jako sám autor promlouvající ke svým posluchačům a čtenářům ústy fiktivních hrdinů. Jak homilie, tak příběhy, sloužily jako materiální roucha nejhlubšího mystického poznání, jehož skryté zjevování rabi Nachman - v návaznosti na Šim'ona ben Jochaj - pokládal za jeden z hlavních způsobů, jimž cadik ha-dor naplňuje svoji ústřední roli v díle individuální i univerzální spásy. Svým učením i příběhy rabi Nachman...HTF - Ústav židovských studiíHussite Theological FacultyHusitská teologická fakult
"All is Good, All is One". Rabi Nachman ben Simcha o-Bratslav. His Personality and his Work.
No full text"Vše je dobré, vše je Jedno" Rabi Nachman ben Simcha mi-Braslav Osobnost a dílo "Al lis Good, All is One" Rabi Nachman Ben Simcha of-Bratslav His Personality and his Work Mgr. Tereza Krekulová My thesis deals whith one of the most fascinating and at the same time controversial figures of Hasidic movement rabbi Nahman of Bratslav whose place in the framework of Hasidic spirituality was quite unique. It purpots to depict the features of his mentality and spiritual life which had the strongest influence on his teachings and his self-reflection as the hidden tzaddik of the whole generation with strong messianic aspiration. Both of his works differ very much from the traditional genres of Hasidic literature: his homilies are marked by their enigmatic, associative style and highly complex hermeneutical structure. His stories, unlike traditional Hasidic legend which depicts the life and miraculous deeds of tzaddikim, don't take place in the Jewish surroundings and tzaddik is present in them as their author who puts his words into the mouth of fictitions heroes. My aim was to prove the essential unity of both these works which played the crucial role na Nahman's messianic strivings. The most important conclusion is that the main purpose of both his teachings and stories which he used as material garments (levushim)..
High-Fidelity Cyber and Physical Simulation of Water Distribution Systems. I: Models and Data
No full textNumerical simulation models are a fundamental tool for planning and managing smart water networks-an evolution of water distribution systems in which physical assets are monitored and controlled by information and communication technologies. While simulation models allow us to understand the interactions between physical processes and abstract control strategies, they ignore key implementation aspects of distributed control systems, such as the required communication over digital links. As a result, the effects of anomalies and faults in the communication on the process control cannot be investigated with existing tools. In this work, we fill this gap by introducing DHALSIM (Digital HydrAuLic SIMulator), a numerical modelling platform combining EPANET-based process simulation with a network and host emulation environment, offering a high-fidelity representation of the processes occurring in the cyber domain. We illustrate DHALSIM's key functionalities by implementing it on a benchmark water distribution system, present case studies of simulated network traffic, and demonstrate how anomalies in the behavior of the communication network affect the process data received by the supervisory control and data acquisition (SCADA) server. In a companion paper, we further illustrate how DHALSIM enables research opportunities in the domain of cyber-physical security. The easily customizable and open source DHALSIM provides a "workbench" for studying smart water networks, developing digital twins, and designing a broad spectrum of engineering solutions
(P043) Endometrial Cancer: FIGO Stage I Outcomes and Trends in Radiation Treatment Modality
No full textSignificant Association of Estrogen Receptor-β Isoforms and Coactivators in Breast Cancer Subtypes
No full textNuclear receptor coregulators are the principal regulators of Estrogen Receptor (ER)-mediated transcription. ERβ, an ER subtype first identified in 1996, is associated with poor outcomes in breast cancer (BCa) subtypes, and the coexpression of the ERβ1 isoform and AIB-1 and TIF-2 coactivators in BCa-associated myofibroblasts is associated with high-grade BCa. We aimed to identify the specific coactivators that are involved in the progression of ERβ-expressing BCa. ERβ isoforms, coactivators, and prognostic markers were tested using standard immunohistochemistry. AIB-1, TIF-2, NF-kB, p-c-Jun, and/or cyclin D1 were differentially correlated with ERβ isoform expression in the BCa subtypes and subgroups. The coexpression of the ERβ5 and/or ERβ1 isoforms and the coactivators were found to be correlated with a high expression of P53, Ki-67, and Her2/neu and large-sized and/or high-grade tumors in BCa. Our study supports the notion that ERβ isoforms and coactivators seemingly coregulate the proliferation and progression of BCa and may provide insight into the potential therapeutic uses of the coactivators in BCa
API evolution on Maven Central: do developers adhere to semantic versioning?
No full textIn this paper, we investigate whether developers of artifacts on Maven Central adhere to semantic versioning. We also investigate whether there is a link between violations in semantic versioning and the popularity of the violating method. Developers can violate semantic versioning by removing or altering methods in their API, which we refer to as breaking changes. They can also violate semantic versioning by extending the API in a patch version, referred to as an illegal API extension. APIs that do not keep their promise of adhering to semantic versioning, will unexpectedly break their dependents during upgrading of dependencies. We have found that these two types of violations do occur in practice. We find that 24% of analyzed artifacts contain breaking changes and 24% of artifacts contain illegal API extensions. Finally, we show that popularity of a method does not have an impact on breaking changes. We conclude that semantic versioning can not always guarantee that upgrading dependencies will not lead to incompatibility. This indicates a need for developers to be more aware of the impact that violating semantic versioning has.CSE3000 Research ProjectComputer Science and Engineerin
ERβ Isoforms Have Differential Clinical Significance in Breast Cancer Subtypes and Subgroups
No full textSIMPLE SUMMARY: ERβ, an ER subtype first identified in 1996, is significantly expressed in ERα-negative breast cancer (BCa) and TNBC. Many studies investigated mostly ERβ1 protein expression in the entire cohort of BCa, and the results are inconsistent. In this study, we simultaneously investigated both ERβ mRNA and three ERβ 1, 2, and 5 protein isoforms in various subtypes and subgroups of BCa. Each ERβ isoform’s mRNA and protein expression seemingly plays a significant role in BCa subtypes and subgroups, and ERβ2 mRNA expression is risk factor for poor outcome. Studies in a large cohort of BCa are needed to explore the potential usefulness of ERβ as a prognostic and predictive marker and a therapeutic target in BCa. Furthermore, the standardization of a ERβ testing protocol may be required for ERβ testing to be utilized in a clinical setting. ABSTRACT: ERβ, an ER subtype first identified in 1996, is highly expressed in different types of BCa including ERα-negative BCa and TNBC. Many studies on ERβ expression investigated mostly on ERβ1 protein expression in ERα-positive and ERα-negative BCa combined. The results are conflicting. This may be due to the complexity of ERβ isoforms, subject heterogeneity, and various study designs targeting different ERβ isoforms and either ERβ protein or mRNA expression, as well as to the lack of a standardized testing protocol. Herein, we simultaneously investigated both mRNA and protein expression of ERβ isoforms 1, 2, and 5 in different BCa subtypes and clinical characteristics. Patient samples (138) and breast cancer cell lines (BCC) reflecting different types of BCa were tested for ERα and ERβ mRNA expression using quantitative real-time PCR, as well as for protein expression of ERα, ERβ1, ERβ2, and ERβ5 isoforms, PR, HER2/neu, Ki-67, CK 5/6, and p53 using immunohistochemistry. Associations of ERβ isoform expression with clinical characteristics and overall survival (OS) were analyzed. ERβ1, 2, and 5 isoforms are differentially expressed in different BCa subtypes including ERα-negative and TNBC. Each ERβ isoform seemingly plays a distinct role and is associated with clinical tumor characteristics and patient outcomes. ERβ isoform expression is significantly associated with >15% Ki-67 positivity and poor prognostic markers, and it predicts poorer OS, mostly in the subgroups. High ERβ2 and 5 isoform expression in ERα-negative BCa and TNBC is predictive of poor OS. Further investigation of ERβ isoforms in a larger cohort of BCa subgroups is needed to evaluate the role of ERβ for the potential usefulness of ERβ as a prognostic and predictive marker and for therapeutic use. The inconsistent outcomes of ERβ isoform mRNA or protein expression in many studies suggest that the standardization of ERβ testing would facilitate the use of ERβ in a clinical setting
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