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Time course of the increase in airway responsiveness associated with late asthmatic reactions to toluene diisocyanate in sensitized subjects.
No full textTo understand better the mechanism of the increase in airway responsiveness associated with late asthmatic reactions, we determined the time course of toluene diisocyanate (TDI) effect on airway responsiveness in six sensitized subjects who exhibited a late asthmatic response after TDI exposure (0.018 ± 0.005 ppm, 30 min) in the laboratory. Airway responsiveness was assessed before TDI exposure and then at 8 hr, 1 day, 1 wk, and 1 mo after TDI exposure. To assess responsiveness we determined the provocative dose of methacholine causing a decrease in FEV, of 20% (PD20 FEV,). The methacholine PD20 decreased from 0.50 mg geometric standard error of the mean (GSEM = 1.54) to 0.06 mg (GSEM = 1.55) (p > 0.001) at 8 hr after exposure to TDI, was still decreased to 0.15 mg (GSEM = 1.93) (p 0.05) at 1 wk, and returned to 0.43 mg (GSEM = 1.71) at 1 mo, indicating that full recovery occurred within 1 to 4 wk. These results demonstrate that TDI-induced late asthmatic response is associated with a reversible increase in airway responsiveness to methacholine and suggest that the TDI effect is linked to an acute inflammatory response in the airways. © 1985
Sensitivity and reactivity to cholinergic drugs and histamine in normal, atopic and asthmatic subjects
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Effetto del cromoglicato sodico sulla risposta bronchiale al carbacolo di soggetti asmatici e rinitici
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TRATTAMENTO IN TEMPO UNICO DI FISTOLA TRANS-SFINTERICA BASSA SEMPLICE POSTERIORE IN REGIME DI ONE DAY SURGERY
No full textMaximal expiratory flow rates and airway resistance in the assessment of bronchoconstriction induced by methacholine and histamine
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Variazioni della "densita' dipendenza" dei flussi massimi espiratori nel broncospasmo indotto dal carbacolo.
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