504 research outputs found
David Martyn Lloyd-Jones 1899-1981 and twentieth-century evangelicalism.
No full textThe purpose of this thesis was to demonstrate the significance of the life and ministry of David Martyn Lloyd-Jones in post-war British evangelicalism and to show that, so far as Protestant churches in England and Wales were concerned, no history of the period can afford to ignore him. It is our contention that despite differences of opinion and self- marginalization Lloyd-Jones was and has remained a major force in evangelical thinking. In order to understand how this developed the thesis has been structured along thematic lines highlighting events, persons and questions. The study begins by setting the stage with a biographical chapter and goes on to examine the kind of impact that Lloyd-Jones's preaching had on Christians of all denominations. He believed preaching to be the greatest need of the day and the position of this thesis is that preaching was Lloyd-Jones's greatest contribution to twentieth- century Christianity. As a preacher he attracted one of London's largest congregations and in chapter three we look at the history and nature of Westminster Chapel comparing it with neighbouring ministries, and establishing the kind of people who went to hear him. Chapters four and five ascertain the factors which shaped Lloyd-Jones's views on the church and show how his Reformed evangelicalism led in a separatist as opposed to an ecumenical direction and finally, to a position which was neither Congregational nor Presbyterian. Our further argument is that while he favoured unity among believers his separatist ecclesiology only exacerbated the situation and left evangelicals more divided than before. Chapters six to eight evaluate Lloyd-Jones's background, the nature of his leadership and the extent of his influence - factors which either shaped or were the outcome of his ministry - and looks at the issues which these questions raise
Using Lexis Objects for Multi-State Models in R
No full textThe Lexis class in the R package Epi provides tools for creation, manipulation and display of data from multi-state models. Transitions between states are described by rates (intensities); Lexis objects represent this kind of data and provide tools to show states and transitions annotated by relevant summary numbers. Data can be transformed to a form that allows modelling of several transition rates with common parameters.
Lexis: An R Class for Epidemiological Studies with Long-Term Follow-Up
No full textThe Lexis class in the R package Epi provides an object-based framework for managing follow-up time on multiple time scales, which is an important feature of prospective epidemiological studies with long duration. Follow-up time may be split either into fixed time bands, or on individual event times and the split data may be used in Poisson regression models that account for the evolution of disease risk on multiple time scales. The summary and plot methods for Lexis objects allow inspection of the follow-up times.
A Bayesian hierarchical framework to integrate dietary exposure and biomarker measurements into aetiological models
No full textIn this study, dietary and serum measurements of vitamin-B6 and folate from two nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC) study were integrated in a Bayesian framework to explore the data measurement error structure and relate dietary exposures to cancer risk. A Bayesian hier-archical model was developed, including: an exposure model, to define the unknown true intake distribution; a measurement model, to relate true intake to observed assessments; and a disease model, to estimate exposure/cancer relationships. Serum and plasma levels of vitamin-B6 and folate were inversely associated with kidney and lung cancer risk, while dietary assessments of these vitamins were not associated with kidney and lung cancer risk. The Bayesian synthesis of this data suggests a protective effect but with substantial uncertainty in the effect size
Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection.
No full textSNPs in the Prostate Stem Cell Antigen (PSCA) gene have been found associated with gastric cancer (GC) risk in a genome-wide association study. This association has been replicated in several populations. In this study we assessed the impact of PSCA genotype on the risk of advanced gastric precancerous lesions and GC. We used baseline gastric histopathology data and DNA from frozen gastric biopsies of 2045 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela, and 180 cases of GC from the same area. We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans. The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03-2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13-1.98 for the dominant model). We also confirmed the association with higher risk of gastric cancer (OR = 2.34; 95% CI 1.36-4.01 for the allele carriers). SNP rs12155758 was not associated with risk of gastric preneoplastic lesions, but we confirmed its association with higher GC risk (OR 1.95; 95% CI 1.29-2.97 for dominant model). We tested the relevance of the presence of the Helicobacter pylori cagA gene, which is known to increase the risk of more severe gastric lesions, but we did not find any clearcut interaction with PSCA SNPs in defining risk of gastric precancerous lesions or cancer
Benefiting from Good Reviews: Part 2
No full textMartyn Clark reflects on how his experiences of going through the peer review process as an author have influenced him as an editor.</jats:p
status
No full textA higher incidence of stomach cancer in ABO blood type A individuals than in those with blood type O has been known for a long time. We studied this association in relation to Helicobacter pylori (Hp) of different cagA status. For our study, we used baseline gastric histopathology data and DNAs from frozen gastric biopsies of 2,077 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela. We analyzed six single nucleotide polymorphisms in the ABO gene, and we assessed the presence of the Hp cagA gene. Odds ratios (ORs) for risk of advanced precancerous gastric lesions were calculated using individuals with normal gastric epithelium or non-atrophic gastritis as a reference. Among individuals carrying a cagA negative Hp infection or no Hp infection, those with blood type A had a lower risk of intestinal metaplasia (IM) and dysplasia than those with blood type O (OR=0.60; 95% CI 0.380.94). In carriers of cagA positive Hp strains, individuals with blood type A had a higher risk of IM or dysplasia than those with blood type O (OR=1.42, 95% CI 1.091.86) and a higher risk if compared to subjects carrying cagA negative strain and non-A blood group (OR=3.82, 95% CI=2.805.20). The interaction between Hp cagA status and blood type was statistically significant (p=0.0006). We showed that SNPs in the ABO gene, predictive of ABO blood groups, are associated with risk of advanced precancerous gastric lesions in individuals infected with Hp, but the assessment of the risk is strictly dependent on cagA status
Naticarius hebraeus Martyn 1786
No full textNaticarius hebraeus (Martyn, 1786) — Fig. 6 A [egg mass: Figs. 3, 11 G, g] Nerita hebraea Martyn, 1786. The universal conchologist, exhibiting the figure of every known shell, accurately drawn, and painted afternature with a new systematic arrangement by the author Thomas Martyn. London, T. Martyn. 4, Vol. 3, pl. 109 + Nerita stercusmuscarum sensu auct. [non Gmelin 1791]. Sabelli et al. (1990), p. 170 + Natica maculatus von Salis, 1793, p. 379. Sabelli et al. (1990), p. 170 + Natica millepunctata sensu auct. [non Lamarck, 1822]. Sabelli et al. (1990), p. 170 + Nacca maxima Risso, 1826. Sabelli et al. (1990), p. 170 + Natica adspersa Menke, 1830. Sabelli et al. (1990), p. 170 Naticarius hebraeus (Martyn, 1786). Kobelt (1901), pp. 76–78, pl. 52, figs. 1–8; Sabelli & Spada (1977), p. 9, fig. 2; Schiró (1978 b), p. 5, fig. 2 (second row); Nordsieck (1982), p. 186, pl. 57, fig. 63.11; Riedel (1983), pp. 287–288, pl. 98 figured; Barash & Danin (1992), pp. 107–108, fig. 115, Terreni (1981), p. 31 Natica hebraea (Martyn, 1786). Hidalgo (1917), p. 486; Villa (1985), pp. 106–107 Natica (Naticarius) hebraea (Martyn, 1786). Settepassi (1972), vol. III, p. 26, pl. 3; Demir, (2002), p. 110 + Naticarius cruentatus (Gmelin, 1791). Poppe & Goto (1991), p. 119, pl. 16, figs. 18–20 + Natica cruentata (Gmelin, 1791). Alf et al. (1993), p. 190, fig. 4 Description Size: Up to 59.2 mm maximal obtainable diameter (m.o.d.) (Italy; Hutsell et al. 2001). Specimens (n = 58) from Giglio Island: 8.1–47.5 mm (mean: 29.6 ± 0.8 mm) height; 7.8–47.1 mm (mean: 29.4 ± 0.7 mm) width. Ratio [h/w] = 1.01 ± 0.005. Aperture approximately 79 % of shell height. General shape: Globose, large bodywhorl, relatively thin-shelled for its size, with 4.5 convex, slightly tabulated whorls and adpressed sutures [teleoconch: 3.5]. Sculpture: Minute barely visible axial growth striae, stronger and easy visible below suture. Shell color: White, cream or yellowish background with dense irregularly arrranged, blurred, brownish dots that have a tendency to coalesce into larger blotches and bands. Protoconch: Uncolored, one embryonal whorl. Aperture & outer lip: Aperture half moon-shaped, oblique, angled anteriorly, rounded at the bottom, fairly thick basal callus; external lip simple, sharp. Fairly thick parietal callus, covering 1 / 4 to 1 / 3 of inner lip. Umbilical area: Wide open, brownish, with well-defined strong, U-shaped, funicle with growth marks, positioned slightly below middle of the umbilical area; funicular callus not enlarged, inner lip without callus. Operculum: Calcareous with numerous narrow, sharply-raised ribs; ribs sometimes mushroom-shaped, with base more narrow than top. Number of ribs varies considerably, independently of body size, from below 10 to> 25, innermost ribs sometimes fused to form flat areas. Animal: Mesopodium and propodium surround shell to same width during crawling; irregularly arrranged, blurred, brownish dots and bands distributed over the entire foot; tentacles colored dark; animal unable to cover entire shell with mesopodium; only lower fringe of shell covered. Egg mass: Flexible, inwardly cambered, paucispiral coiled band of mucus-cemented sand grains (Figs. 3, 11 G/g), 1.25 circles; outer diameter 7.5 mm (n = 1). Differential diagnosis: Irregular brownish dots, strong funicle, operculum with numerous sharp ribs, and large size easily distinguish the species from all other Mediterranean naticids except for N. stercusmuscarum. For differences to N. stercusmuscarum, see under that species. Geographical distribution Giglio Island: Campese Bay (1),´ Swiss House ´(9), Pt. del Faraglione (2), Pt. delle Secche (3) Alf et al. (1993):´Found singularly at the beach after storm at Bay of Campese, Giglio Island.´General distribution: Contrary to several publications (Hidalgo 1917, Schirò 1977), this species is probably strictly Mediterranean, ubiquitous and common from the Strait of Gibraltar to the Aegean Sea (Demir 2002).Published as part of Huelsken, Thomas, Marek, Carina, Schreiber, Stefan, Schmidt, Iris & Mann, Michael Holl-, 2008, The Naticidae (Mollusca: Gastropoda) of Giglio Island (Tuscany, Italy): Shell characters, live animals, and a molecular analysis of egg masses, pp. 1-40 in Zootaxa 1770 on pages 18-19, DOI: 10.5281/zenodo.18211
Martyn Brewster: prints 1975-2007
No full textThis co-authored book offers the first systematic account of the silkscreen monoprints of Martyn Brewster, focusing on his prolific output in the period 1975–2007. The book locates printmaking as an essential feature of Brewster’s creative output, which is more commonly characterised from a different angle through his formidable international reputation for painting in oils and acrylics. The book develops my ongoing project of inquiry into, and dialogues with, Brewster's work – a project which has included: contributions to exhibition catalogues, most notably those of the Jill George Gallery in London; catalogues for stands at international art fairs, especially in the USA; forewords to touring exhibition catalogues such as Colour and Form (Walford Mill Crafts, 2010); and the publication of what has become the standard work on the artist, my monograph Martyn Brewster (Scholar Press, 1997).
The current book was commissioned by Canterton Books, a publisher which specialises in works on contemporary visual artists based in the South West of England. I wrote one of two extended essays on Brewster's work. 'The Endless Line' is a survey of the artist's print oeuvre, an analysis of the context of his work and its influences, and a study of the relationship between his extensive print output and his acrylic and oil paintings. The essay also describes his particular contribution to the form of the artist's book.
I worked with my co-author to select and edit the full catalogue of supporting images of prints from across Brewster's career. The book has been used to support the artist's national and international gallery network, and since its publication in 2008 has accompanied a series of exhibitions in London galleries and international art fairs, including Chicago and San Francisco
Restoration of the Martyn brothers house as a bright example of the work of the architect N.M. Socolow
No full textThe paper discusses the history of the Martyn Brothers House, as well as the practice of restoring this object of cultural heritage of federal significance. The author of the mansion is Nikolai Matveevich Sokolov (1859-1906), the city architect of the late XIX - early XX centuries in Rostov-on-Don. To characterize the measures for the protection and modern practice of restoration of one of the brightest examples of N. M. Sokolov’s creativity – the Martyn Brothers House in Rostov-on-Don. The main method of research was historical analysis - the study of the origin, formation and development of objects in chronological order, as well as archival and full-scale surveys of the object, photo fixation. The characteristic of practice of restoration of works of “brick style” using Martyn Brothers House as a bright example of the work of the architect N.M. Sokolov was given. The mansion is of scientific and practical interest. During the research, the main techniques and methods used in restoration practice that can be used by modern restorers were identified. After the completion of restoration work on the site of the Martyn Brothers House, the original historical and architectural appearance of the magnificent monument of the late XIX century was restored, taking into account all the lost parts of the building
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