1,721,406 research outputs found
The soluble interleukin-2 receptor as a new biological marker in diseases
No full textThe biological and clinical role of sIL-2r has been investigated in a variety of reactive and neoplastic conditions, providing new useful prognostic and pathogenetic informatin
Flow cytometry for minimal residual disease detection in acute lymphoblastic leukaemia
No full textFlow cytometry for minimal residual disease detection in acute lymphoblastic leukaemi
Signaling pathways activated by the B-cell receptor in chronic lymphocytic leukemia
No full textOver the past decade, several features of the B-cell receptor (BCR) complex have emerged as major markers for prognostic classification of B-cell chronic lymphocytic leukemia (B-CLL). In particular, the absence of somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), the presence of ZAP-70 and a higher ability of the BCR to translate signals within the cell have been associated with an aggressive clinical course. Indeed, the stratification of patients with B-CLL based on BCR features suggests that heterogeneity of B-CLL clinical courses may reflect BCR signaling differences that have arisen during the evolution of leukemia. Therefore, characterizing BCR signaling profiles may help to identify signaling markers useful for patient stratification, disease monitoring and therapeutic targeting in B-CLL
Biopathologic features of Hodgkin's disease
No full textThe neoplastic nature of Hodgkin's disease (HD) is suggested by several lines of evidence, including aggressive clinical course, presence of proliferating atypical cells morphologically recognized as Hodgkin's and Reed-Sternberg cells (H-RS), aneuploidy, and, in the minority of cases, clonality. Nevertheless, the etiopathogenesis of HD still remains elusive, and probably diverse. This uncertainty is partly due to the peculiar histology of HD lesions, characterised by the paucity of the putative neoplastic cell component, i.e. H-RS cells, admixed to a variety of reactive cells which prevent an exhaustive investigation at molecular level. Nevertheless, the possible involvement of different molecules with oncogenic potential has been recently suggested on the basis of immunohistological and molecular biology studies. These include oncogenes such as bcl-2 and MDM2 and anti-oncogenes such as p53. In addition, a large amount of data has accumulated on the possible role of EBV infection in HD. The colonization of lymphoid tissues by immortalized H-RS cells can account for the derangement of cytokine networks leading to microenvironmental and systemic abnormalities. In addition, a variety of soluble receptors (sIL-2R, sCD30, sTNF-R), and adhesion molecules (sICAM-1) are abnormally produced at sites of disease involvement. Some of these molecules still retain the ability to bind their ligands and can potentially contribute to the derangement of immune mechanisms observed in HD. Many of these soluble molecules can also be found in the patient's sera providing new potential prognostic and follow-up parameters in HD patients. The comparative analysis of the same molecules within the tissue, using immunohistochemistry, and in the blood, using immunochemical assays, appears as a promising informative approach
Le molecole solubili in oncoematologia
No full textRassegna del ruolo e significato di vari recettori solubili in patologia neoplastica ematologic
Diagnosi immunoistologica dei linfomi non-Hodgkin.
No full textdescrizione di tecniche innovative per la diagnostica differenziale dei linfomi non HOdgkin
The significance of leucocyte phenotype: a report from the November Meeting of the British Society for Immunology. London, U.K., November 12-13, 1987.
No full texta detailed report a critical assessementt of data presented at the meeting has been provide
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