1,720,975 research outputs found
Studio istopatologico preliminare sull'iride e sul cristallino in pazienti affetti da malattia di Behçet.
No full textUveitis heralding previously unknown luetic and HIV infection. Syphilitic uveitis in an Italian referral center.
No full textPurpose. This study was conducted to determine the incidence of luetic uveitis in the
last seven years at our uveitis center and to describe the characteristics and the role of
uveitis in the diagnosis of syphilitic infection with or without unknown HIV infection.
Methods. We retrospectively reviewed syphilitic uveitis in patients observed at our center
between 2004 and 2010. The diagnosis was based on the serological evidence for syphilis,
uveitis, exclusion of other etiologies. All patients had HIV testing.
Results. We describe 14 new cases of luetic uveitis: 6 co-infected with previously
unknown HIV-infection had panuveitis, while the most common presentation in HIVnegative
patients was posterior uveitis.
Conclusions. Syphilis has been recognized as reemerging disease. The ocular
inflammation can be the first symptom of syphilis. This study underlines the importance
of a prompt and correct diagnosis of this ocular disease
Ocular Behçet's Disease: Changing Patterns Over Time, Complications and Long-Term Visual Prognosis.
No full textPURPOSE:
To investigate demographic, clinical features and complications of Italian patients with ocular Behçet's disease (BD) over time.
METHODS:
Retrospective study of 385 patients examined from 1968 to 2011, 265 of whom had follow-up ≥ 12 months.
RESULTS:
A significant increase in the proportion of females (p = 0.03) and anterior uveitis (p < 0.001), and a decrease in the complete type of BD in all patients (p = 0.003) and in males (p = 0.002), and in hypopyon (p = 0.024) were observed over time. Optic neuropathy (p < 0.0001), maculopathy (p = 0.002), retinal detachment, and retinal neovascularization (p = 0.02) decreased over time, with no difference between genders, concomitant with an increase in the use of immunosuppressive drugs (p = 0.003). Visual acuity ≤1/10 was detected more often in males than females (p = 0.003).
CONCLUSIONS:
A significant shift in clinical manifestations of BD patients was observed over 44 years. Immunosuppressive therapy succeeded in lowering ocular complications. The incidence of ocular BD is increasing in females, but visual prognosis is still worse in males
Effects of intravitreal bevacizumab on inflammatory choroidal neovascular membrane
No full textAbstract: Purpose. To test the efficacy of intravitreal bevacizumab (IB) in the treatment of inflammatory choroidal neovascularization (CNV).
Methods. A prospective interventional study on patients with subfoveal CNV secondary to posterior/diffuse uveitis treated with 1.5 mg/0.05 mL of IB. Eight eyes of 8 patients, with mean follow-up of 19.25 +/- 6 months, were included. The measurements adopted were 1) changes in best-corrected visual acuity (BCVA), 2) reduction in CNV size, and 3) changes in central foveolar thickness (CFT) measured by optical coherence tomography.
Results. The mean number of intravitreal injections was 3.75 +/- 1.38. After IB treatment, the mean BCVA improved significantly, from 0.27 +/- 0.10 before treatment to 0.5 +/- 0.29 after treatment (p<0.05). The CFT also responded well to IB, with 402.75 +/- 114.11 mu m preoperatively, and after treatment 300.5 +/- 90.98 mu m (p< 0.01). Notably, all patients showed a reduction in the size of the CNV and BCVA remained stable or improved in 7 eyes (87.5%). No episode of active intraocular inflammation was observed and patients continued to receive their systemic steroid or immunosuppressive therapy.
Conclusions. Intravitreal bevacizumab may be an additional strategy in inflammatory CNV of eyes with controlled uveiti
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