1,721,521 research outputs found
Lymphoid tissue reactions in rheumatoid arthritis
No full textFrequently, the immune cell infiltrate of chronically inflamed tissues develops functional germinal centres and acquires structural features of secondary lymphoid organs. Ectopic lymphoid structures occur in peripheral tissues not only during autoimmune diseases but also in tumors (reactive infiltrate), chronic infections and graft rejection, indicating a strong link between lymphoid neogenesis and persistent antigen driven immune/inflammatory responses. There has been a renewed interest in ectopic lymphoid neogenesis, as better understanding of the mechanisms underpinning this process could contribute to elucidate the bio-pathological mechanisms involved in transition from acute-self resolving to chronic immunological aggression as well as identify novel therapeutic targets. Here we critically review recent clinical and biological studies addressing the role of ectopic lymphoid neogenesis specifically in rheumatoid arthritis
Unmasking the anti-inflammatory cytochine response in rheumatoid synovitis
No full textIn RA, synovial CD30+ cells would be part of the Th2‐type response acting as a homeostatic mechanism to counterbalance the proinflammatory events driven by Th1‐type cells/cytokines. They would exert their anti‐inflammatory activity through the synergistic action of IL‐4 and IL‐10. The possibility of evaluating such activity by simply measuring the levels of circulating sCD30, in all phases of the disease (relapse, remission) and in response to therapy, may offer better insight into the mechanisms involved in controlling disease evolution
Chemokines in arthritis: key molecules in pathogenesis and potential therapeutic targets
No full textAn increasing wealth of evidence suggests an important role for chemokines and their receptors in the pathogenesis of inflammation. In this review, the authors explore the role of chemokines in inflammatory joint diseases, with particular emphasis on rheumatoid arthritis. Recent progress aimed at modulating the chemokine and chemokine receptor system for therapy will also be discussed
Lactate influx through SLC5A12 in CD4+ T cells fires up inflammation via metabolic rewiring
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