1,721,035 research outputs found
Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets
No full textAorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies,
currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult
to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data.
No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus,
their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways
involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress
(OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these
aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and
potential solutions and approaches, as well as some potential treatments
The need for the STS Score risk stratification system for aortic root aneurysms surgery
No full textIn this editorial we discussed the need of STS score in aortic root surger
Right ventricular inflow obstruction related to late Candida albicans infection of implantable cardioverter-defibrillator leads
No full textEchocardiogram transoesophageal, CXR and positron emission tomography–computed tomography scan images showing a fungal endocarditis mass deter- mining right ventricle inflow obstruction in a 74-year-old woman with a history of fever, right ventricle failure, multiple PE and cultures were positive for Candida albicans. Intraoperative view. The mass obstructed the right ventricular inflow, attached 3 leads with silicone–polyurethane copolymer (OptimTM) and was eradicated with right atrial surgical approach
Anaortic off-pump coronary artery surgery as a primary strategy to reduce the risk of neurological complications
Full text linkEndocarditis: Cardiac Surgery Treatment/A Thrilling Challenge in Cardiac Surgery
Full text linkEndocarditis: Cardiac Surgery Treatment/A Thrilling Challenge in Cardiac Surger
A Narrative Review: Syndecans in Aortic Aneurysm Pathogenesis and Course—Biomarkers and Targets?
Full text linkThe maintenance of the integrity of the entire endothelium, glycocalyx included, and, therefore, of tissue aorta’s homeostasis, depends on the expressions of several molecu- lar pathways and their interactions, such as syndecan molecules. Alterations in syndecans, i.e., quantitative alterations or linking to their shedding, contributes to invoking endothe- lium dysfunction, which causes damage to the vessel wall due to the increased production of growth-stimulating and pro-inflammatory gene products. Inflammatory processes neg- atively affect the integrity of the endothelial glycocalyx, a dynamic layer of the luminal portion of endothelial cells composed of proteoglycans, glycoproteins, and glycosaminogly- cans, i.e., syndecans. In turn, structural alterations in the endothelial glycocalyx influence the coagulative state, increasing pro-thrombotic processes. The family of syndecans con- stitutes a major component of glycocalyx or, more accurately, the major source of cell surface heparan sulfate. It encompasses four components: syndecan-1, syndecan-2, and syndecan-4 (with syndecan-3 only expressed in neural tissue), which have a fundamental role in regulating the events of acute and chronic aorta damage subsequently correlated with the formation of aneurysms. As such, the aim of our review is to highlight the current knowledge on the roles of syndecans and to analyze their relationship with the pathological processes of the aortic wall based on the most recent literature
Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms
Full text linkAorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments
The endoclamp device as a useful strategy during redo surgery on the aortic root and arch
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