4,192 research outputs found
MotoGP and heterogeneous design
No full textThis chapter takes as its central focus the design of the MotoGP racing motorcycle. Our key aim in scrutinising MotoGP is to conceptualise the location of design and its meaning: to reflect upon where and how design happens; and to enrich understandings of the heterogeneous, networked and distributed character of design. Whilst many consumer objects are mobile, our analysis extends beyond the design of the motorcycle as a single mobile artefact to consider both the motorcycle-rider assemblage (Pinch and Reimer 2012) as well as the complex architecture of design technologies which support MotoGP racing. We stress the agency of material objects and non-material inputs (expressions and emotions) that operate relationally and act upon the MotoGP motorcycle, crucially defining its movement and performance. The chapter emphasises the multifaceted nature of design: it runs through mechanical engineering, the design of electronic control systems, the regulation of international motorcycle racing; and the physical body of the rider
Conclusion
No full textIn this conclusion, we identify a range of themes that signpost both the collective contribution of chapters and avenues for further enquiry and exploration. We consider the effects of movement on design as unfinished accomplishments; the role of design techniques and practice in the process of conceiving the mobile subject; and the disciplining effects of design on the mobile subject. The final section highlights the importance of understanding designed objects and designers as moral and political actors
Legible London: mobilising the pedestrian
No full textThis chapter examines the design of the Legible London pedestrian wayfinding system. Overseen by Transport for London (TfL), this innovative scheme for enabling walking has developed from an early prototype study in 2007 to become a key part of transport policy in the UK’s capital city (AIG 2006, 2007; Arquati 2008; TfL 2014). An integrated combination of signs, pedestrian focused mapping and other directional information, Legible London has two complementary aims; to help people plan journeys on foot; and to give people the confidence to walk and explore. The scheme consists of a city-wide, consistent, pedestrian navigation system encompassing on-street wayfinding elements supported by identical information in public transport nodes (e.g. tube stations and bus stops) and paper based products as well as ongoing development of the provision of digital mapping information. The current on-street system is comprised of a mixture of information boards, known as ‘liths’ that come in a standardised range of sizes (see Figure 3.1), directional fingerposts, wall mounted signs and a range of supporting printed maps located in bus stops and inside tube stations. Information on all liths is presented in a hierarchical fashion: a top yellow beacon locates the sign in busy urban environments, directional information is given to nearby points of interest (replicating traditional finger signs), whilst differently scaled ‘planner’ and ‘finder’ maps locate the lith within 15 minute and 5 minute walk scales respectively. A street index also is provided
Introduction
No full textThe central contribution of this edited collection is to foreground relationships between individual designed objects and wider systems of mobility. In bringing a design perspective to bear on understandings of mobilities, we seek to better understand the tools, assumptions and processes through which the subjects, practices and spaces of mobility are ‘made up’. At the same time, bringing a mobilities perspective (that mobility is meaningful and powerful) to design enables us to understand how shifts in the fluidity and circulation of people, practices and materials are reshaping design practices. In broad terms Mobilising design emphasises the role of design as process, practice and outcome in producing mobility. Together, the book’s contributors develop multi-disciplinary understandings of design, drawing upon diverse literatures including design history, product design, architecture and cultural geography
Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis
No full textParticularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP (integrin linked kinase (ILK)-PINCH-Parvin-α) complex. PINCH itself binds to ILK and to another protein known as Rsu-1 (Ras suppressor 1). We generated PINCH 1 and PINCH 2 Double knockout mice (referred as PINCH DKO mice). PINCH2 elimination was systemic whereas PINCH1 elimination was targeted to hepatocytes. The genetically modified mice were born normal. The mice were sacrificed at different ages after birth. Soon after birth, they developed abnormal hepatic histology characterized by disorderly hepatic plates, increased proliferation of hepatocytes and biliary cells and increased deposition of extracellular matrix. After a sustained and prolonged proliferation of all epithelial components, proliferation subsided and final liver weight by the end of 30 weeks in livers with PINCH DKO deficient hepatocytes was 40% larger than the control mice. The livers of the PINCH DKO mice were also very stiff due to increased ECM deposition throughout the liver, with no observed nodularity. Mice developed liver cancer by one year. These mice regenerated normally when subjected to 70% partial hepatectomy and did not show any termination defect. Ras suppressor 1 (Rsu-1) protein, the binding partner of PINCH is frequently deleted in human liver cancers. Rsu-1 expression is dramatically decreased in PINCH DKO mouse livers. Increased expression of Rsu-1 suppressed cell proliferation and migration in HCC cell lines. These changes were brought about not by affecting activation of Ras (as its name suggests) but by suppression of Ras downstream signaling via RhoGTPase proteins. In conclusion, our studies suggest that removal of PINCH results in enlargement of liver and tumorigenesis. Decreased levels of Rsu-1, a partner for PINCH and a protein often deleted in human liver cancer, may play an important role in the development of the observed phenotype. © 2013 Donthamsetty et al
The German Internationale Bauausstellung (IBA) and Urban Regeneration: Lessons from the IBA Emscher Park
No full textURBAN. REGENERATION. Lessons. from. the. IBA. Emscher. Park. Philip Pinch and Neil Adams Summary The German approach of using international building exhibitions (Internationale Bauausstellung) to provide an impetus for innovation ..
Waterspace planning and the River Thames in London
No full textLondon is a city that stands, for many, at the pinnacle of neoliberal global urbanization and market-led residential and commercial property investment. Its iconic River Thames has become a focus for much of this development, particularly of luxury apartments. There has been an emerging sense that the river increasingly has been captured by a specific set of class interests and its edges privatized to the exclusion of other claims on the Thames’ identity, usage and meaning. Although cognizant of the power of private and property interests and the leverage they may exercise through state mechanisms, this paper interprets London's ‘waterspace’ policy and planning in a way that rejects interpretations of the river that simplistically foreground the will of capital and global neoliberalism
Mobilising Design
No full textThis book brings together research working at the boundary between design knowledges and mobilities, offering a novel collection for both theorists and practitioners. Drawing upon detailed case studies, it demonstrates the diverse roles of design in shaping mobility at different spaces and scales: across cities; within different types of buildings and infrastructures; and through commuting, work and leisure activities
The FM and PL Libraries Documentation
No full textBuilding complex SPMD code in an ecient and portable way is nowadays a challenge, especially when there is no uniformity of tools and libraries across platforms. The Fast Messages (FM) and the Portability Library (PL) where both designed to provide the basis of an abstract enough framework for C, so that problems can be coded and ported to any supported platform with no more than a few changes in the makeles and a recompilation. The FM library provides a message passing communications library built around the Berkeley Active Messages library. The PL library provides the primitives for host to node communication for problem initialization and results collection, as well as other miscellaneous and potentially non-portable primitives. This technical report contains the documentation for both libraries.Technical report LCSR-TR-25
Increasing science, technology, engineering, and mathematics skills using Project Lead the Way
No full textIncludes bibliographical references
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