1,721,005 research outputs found
Dermocosmetics: beneficial adjuncts in the treatment of acne vulgaris
No full textIntroduction: Dermocosmetics are increasingly being recognized as an integral part of acne management. Dermocosmetics may minimize the side effects of acne medications, provide synergistic effects by improving the efficacy of other treatments, and limit exposure to environmental factors such as ultraviolet radiation. We aimed to provide an overview of the active ingredients and different types of preparations used in dermocosmetics for acne, and highlight supporting evidence for their use in clinical practice. Methods: A literature search for selected key words was performed using PubMed. Additional papers were identified based on author expertize. Results and discussion: The different types of active ingredients in dermocosmetics for acne can be classified as: sebum-controlling, antimicrobial, anti-inflammatory, anti-oxidant and/or keratolytic. Such agents may modulate the pathogenic pathways in acne. Dermocosmetics can be formulated as emulsions/creams, cleansers or camouflaging make-up. Dermocosmetics are useful treatment adjuncts for acne and have been shown to improve the clinical signs of acne, reduce transepidermal water loss and modify sebum production. Dermocosmetics have also been associated with reducing side effects of pharmacological treatments, high levels of patient satisfaction and increased adherence to treatment regimens. Together this evidence supports the use of dermocosmetics in clinical practice
Apoptosis and Signaling in Bullous Diseases: Pemphigus
No full textAutoimmune bullous diseases comprise a heterogeneous group of disorders, which not only differ with regard to their immunological characteristics but also with regard to genetic and environmental predisposing factors. A strong association with HLA alleles was found in pemphigus, mucous membrane pemphigoid, pemphigoid gestationis and epidermolysis bullosa acquisita, whereas in bullous pemphigoid, this association appeared much less prominent. Recently, the first non-HLA genes have been associated with pemphigus vulgaris. In pemphigus vulgaris and foliaceus, the potential impact drugs, smoking and vaccination have been described, while in the endemic forms of pemphigus foliaceus, the role of environmental factors, including infectious agents, is emerging
FAS LIGAND IN PEMPHIGUS SERA INDUCES KERATINOCYTE APOPTOSIS THROUGH THE ACTIVATION OF CASPASE-8.
No full text- …
