7 research outputs found
Exports, Imports, and Economic Growth in India
No full textABSTRACT
The purpose of this research study is to shed light on the causal relationship between foreign trade and economic growth in India. This study analyzes Export-led growth (ELG) and Import-led growth (ILG) hypothesis in India. The author does so by analyzing the yearly data of Export, Import and Gross domestic product of India between 1980 and 2016. The author employed augmented Dickey-Fuller method and Phillip-Perron method to transform the all the data series into a stationary form. The author finds that all three variables i.e. Export, Import and Gross domestic product are highly positively correlated to each other. The result of Johansen co-integration test indicates cointegration and long-haul relationship among the variables. The result of the Granger causality and Toda-Yamamoto causality test shows unidirectional causal relationship between export and economic growth; the one-way causation exists between import and economic growth while economic growth causes export and import in India. The result of the impulse response function indicates that a change in the GDP is due to its own shocks whereas the impact of export shows certain effect on GDP. The analysis of the variance decomposition demonstrated that only 28.25% fluctuations in the GDP were explained due to its own shocks. Thus the outcome of the study indicates importance of export and import for economic growth is significance and foreign trade is heavily relied on economic growth of the countr
Correction: Onasemnogene Abeparvovec for Treating Pre-symptomatic Spinal Muscular Atrophy: An External Assessment Group Perspective of the Partial Review of NICE Highly Specialised Technology Evaluation 15 (PharmacoEconomics - Open, (2023), 7, 6, (863-875), 10.1007/s41669-023-00439-6)
No full textThis article was originally published under a CC BY-NC license, but has now been made available under a Creative Commons Attribution 4.0 International License (), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The PDF and HTML versions of the paper have been modified accordingly. The original version of this article was revised due to a retrospective licence change request
Clinical characterization of Collagen XII-related disease caused by biallelic <em>COL12A1</em> variants
Get PDF\ua9 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. Objective: While there have been several reports of patients with dominantly acting COL12A1 variants, few cases of the more severe recessive Collagen XII-related disorders have previously been documented. Methods: We present detailed clinical, immunocytochemical, and imaging data on eight additional patients from seven families with biallelic pathogenic variants in COL12A1. Results: All patients presented with a consistent constellation of congenital onset clinical features: hypotonia, dysmorphic features, most notably gingival hypertrophy, prominent distal joint hyperlaxity, with co-occurring contractures of large joints, and variable muscle involvement, evident both clinically and on muscle imaging. Five patients presented with a severe congenital phenotype manifesting with profound weakness, significantly delayed or minimal attainment of motor milestones, respiratory insufficiency, and feeding difficulties. Three patients presented with mild-to-moderate muscle weakness and delayed milestones but were able to achieve independent ambulation. Patients were found to have biallelic loss-of-function COL12A1 variants, except for one family (p.I1393Ffs*11/p.A1110D). Consistent with the variable clinical spectrum, in vitro immunocytochemistry analysis in fibroblasts ranged from complete absence of Collagen XII expression in a patient with severe disease, to a mild reduction in a patient with milder disease. Interpretation: Here we characterize the clinical presentation, muscle imaging, and dermal fibroblast immunostaining findings associated with biallelic variants in COL12A1, further establishing COL12A1 as a recessive myopathic Ehlers–Danlos syndrome (mEDS) gene, and expanding the clinical spectrum to include a milder EDS phenotype
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy
Get PDF\ua9 2022, The Author(s). Missense variants in RNA-binding proteins (RBPs) underlie a spectrum of disease phenotypes, including amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Here, we present ten independent families with a severe, progressive muscular dystrophy, reminiscent of oculopharyngeal muscular dystrophy (OPMD) but of much earlier onset, caused by heterozygous frameshift variants in the RBP hnRNPA2/B1. All disease-causing frameshift mutations abolish the native stop codon and extend the reading frame, creating novel transcripts that escape nonsense-mediated decay and are translated to produce hnRNPA2/B1 protein with the same neomorphic C-terminal sequence. In contrast to previously reported disease-causing missense variants in HNRNPA2B1, these frameshift variants do not increase the propensity of hnRNPA2 protein to fibrillize. Rather, the frameshift variants have reduced affinity for the nuclear import receptor karyopherin β2, resulting in cytoplasmic accumulation of hnRNPA2 protein in cells and in animal models that recapitulate the human pathology. Thus, we expand the phenotypes associated with HNRNPA2B1 to include an early-onset form of OPMD caused by frameshift variants that alter its nucleocytoplasmic transport dynamics
Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study
Get PDF\ua9 2024 Muntoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Evaluations of treatment efficacy in Duchenne muscular dystrophy (DMD), a rare genetic disease that results in progressive muscle wasting, require an understanding of the ‘meaningfulness’ of changes in functional measures. We estimated the minimal detectable change (MDC) for selected motor function measures in ambulatory DMD, i.e., the minimal degree of measured change needed to be confident that true underlying change has occurred rather than transient variation or measurement error. MDC estimates were compared across multiple data sources, representing >1000 DMD patients in clinical trials and real-world clinical practice settings. Included patients were ambulatory, aged ≥4 to <18 years and receiving steroids. Minimal clinically important differences (MCIDs) for worsening were also estimated. Estimated MDC thresholds for >80% confidence in true change were 2.8 units for the North Star Ambulatory Assessment (NSAA) total score, 1.3 seconds for the 4-stair climb (4SC) completion time, 0.36 stairs/second for 4SC velocity and 36.3 meters for the 6-minute walk distance (6MWD). MDC estimates were similar across clinical trial and real-world data sources, and tended to be slightly larger than MCIDs for these measures. The identified thresholds can be used to inform endpoint definitions, or as benchmarks for monitoring individual changes in motor function in ambulatory DMD
0002
No full textTHK DAILY PALO ALTO TIMES
READY FOR BUSINESS
Just three months A. Q. we are ready for business tn the old stand.
Special Opening Days
Thursday, July 19
Friday, July 20
Saturday, July 21
On Saturday afternoon and evening every lady who visits our store
will be presented with an envelope containing half a dozen Stanford
souvenir post cards. Each envelope will be numbered and the lucky
numbers will draw the following prizes:
I Decennial of Stanford Song, doth, 12.00.
1 Decennial, paper binding, 1.00.
1 Stanford Souvenir Album, 1.00.
1 Stanford View Book, 50c
This is no lottery. All the gifts are entirely free. No need to boy
anything and no conditions to fullfil except to visit the store. This is to
pay you for your time.
H. W. SIMKINS
Bookseller and Stationer
106 UNIVERSITY AVENUE
CHOCOLATE AND CARAMEL
THESE ABE DAINTIES LOVERS FUZE;
WHO WOULD SPEED HIS WOOING WELL-
BE SHE PEASANT MAID OR BELLE-
NEEDS Bin' TO BE CANDY-WISE. •
CARAMEL AND CHOCOLATE
THESE TO COURTING ADD A ZEST;
HE MAY SAFELY BRAVE UiS FATE
WHO HAS LAND-MARKED EVERY "DATE"
with box of Wilson's Best.
I........
.,.»,,,siaassaaasit
HELPS MRS, HARTJE
BISTER in.l.s OP HAVING WRITTEN THK (')ACHMAV'H NAME
ON' AX ENVELOPE.
Pittsburg, July 19.—Tbe alien d-
ance at thc opening of tba trial ol
tli-- Hnrtji- divorce cum- tod*}- wn
smaller than on any duy since It be-
Baa.
Miss Ida, B. Scott, **MUX ot Mi.
Hsrtje, the respondent, who was on
tbo stand when court adjourned yesterday, waa attain called. The wltnei
aald that Mra. Hartje never wrou
letters or telephoned to Thomas Mu
dine, th<* co-rnspnndciit.
Concerning the envelope known n?
exhibit 3-t, Miss Sscott said she had
addressed It to Tom Mediae, th-
coflthman, for Annie l.utx, a do-
tui-Hiic. This Is thc only envelope so
Tar Introduced la the evidence, and
Is the one the experts for Hartjt
skid was In the respondent's handwriting.
Miss Scott nlHo testified (hat she
bad Riven to the domestic some teller paper ot (he kind u»od by Mr*
Hartje. An effort wll now be mad-
to discover what become of this pa
per. and Annie Lutx will be place.'
on the stand to tell what she did
with the enve'o-ie and paper.
Thus the presence of the slngli
envelope among all the love letter)
prcnented by counsel lor the libel*
lam would bu explained.
At yesterday* hearing Mrs. Scoti.
mother of Mrs. Hartje. teitlficd (hat
Mrs. Hun jr could nul have wrlttei.
the letters to Madlne. The mother's-
tcstimony concerning the ■ "Susie
Wagner" letter, known as exhU''-
No. 6, was sensational. She drctarec
that she had seen the "Susie Wag
ner" letter before It wns mailed,
that there were statements tn the or
Iglnal letter that were not In th<
. lii K---1 Wagner letter that was ex
hiblled In court, and thai the lettci
produced in court contained some
matements that wen- not In the original and real Wagner letter. Thh
letter was one of lhe "Riandards" In
the case until Mrs. IJnrlJe denied
having written -the copy that was
shown her and declared she had been
deceived.
John F. Scott, Mrs. Harlje's father,
declared that It was Impossible for
his daughter to have met Madlne or
to have telephoned to him, as she
was never out of the houae alone, and
all In the Scott home usually knew
when thctelophone rang.
Three more bank clerks were put
on the stand by Mrs. Hartje"* counsel
today, all of whom testified that the
letters, exhibit* No*, 10 to 35. were
not written by tbe author of the admitted "standards."
Ills* Scott was ahovm (he letter*
•faring In the case, and picked out
a number ot (he missives having been
written on stationery belonging*
either to herself or one of her sisters.
Sbe said the maid. Anal* I.utx. had
been given this kind of letter paper,
and she wrote letter* quite frequently. The tcsttniony caused a sensation, and the plaintiffs attorneys followed with a searching cross-examination to break its effect.
The defense Introduced Thoma*
Scott, a relative of Mrs .Hartje, who
testified that he was the "Tom" lo
whom Mrs. Hartje telephoned so
often, and (hen presented Miss Mary
Dillon, who testified she was the
■"Mary" to whom "Tom" Mudlne telephoned from S-culenberg's stable.
A PEACE GONFERENGE! DISPLAYS NO EMOTION
UOMMIKKION TO MEET OS IIOABO
THK UNITED STATES n:i lv
i It M IRI1I I -.in \i: '
San Salvador, July 18.—The Pesos
Commissioners of Salvador are Or.
J. It. Pacaa and Senor Oalles. They
wll) go on board tbe United State*
cruiser Murblehead a( Acajutla io-
rtay with thc com mlas) oners of Honduras and proceed to Saa Jose,
Guatemala, where tbe other commlav
stoner* will be taken on board, and
the party will put to sea and draw
up and Nlgn the treaty of peace.
The body ol the Salvadorean general, Thomas Regllndo. who was
killed July 11 In a battle fought at
Jlraro, Guatemala, arrived at Guatemala City In a complete state of decomposition, making Us repatratlon
Impossible.
Senor Jose Roan Paras, who waa
sent by President Ktwjilon to come to
the United Stales and present Salvador's side of thc Cm-trsl American
dispute lo (his Government.previous
to (he serious battle* between Guaie-
muliiti and Salradoreoit troops. Is thc
Salvadoreun Minister of the Interior
who attracted much attention
1902 by denouncing Chief Justice
Henry Strong and Don M. Dickinson,
with whom he met In Washington to
arbitrate the claim of the Salvadorean Commercial Compauy against Salvador.
Washington, July 19.—The armistice between . (tie warring Central
American republics wen( into effect
at 6 o'clock this niornlnx*
Mr. Munot, (he Guatemalan Minim-r, called at the State Department
today and announced lhat he bnt
been advised by his Government of
th* selection of three commissioners
and a secretary to represent Guate-
mala at the peace conference. They
wilt go to San Jo**, Guatemala, In
time to board the Marhlehead, which
is expebcied to reach there to-morrow.
Pound Dog Tag In Can of Meamt.
Washington. July 19.—"Respectfully and prayerfully referred."
This is tbe indorsement of President Roosevelt on the story that
some Chicago man fonnd In Chicago
the license lag of a dug ln a can ol
'tinned meat."
The story tbat a tag bad been
found under such circumstance* bar
been cried for some time, but recently some person undertook to scud ar
account of the matter to the President. The Chief Magistrate sent th.
•tor). Indorsed a* above to Commit
alonrr Nelll lo Investigate.
DOLT AM-IANCE I(V EMPERORS.
Kmpt-ror* of Germany. Aut-lri* and
ltuftsla l-'orm •» Ounpact. «
Paris. July 19.—In tho recent Interview at Schocnbrunn Palace, near
Vienna, between the Emaeror of
Austria-Hungary and tbe German
Eni-wror their Majesties deliberated
on-* the means to adopt In case of a
revolution In Russia, Emperor Nichols* being advised of tbe general nature of tbe deliberations. It waa de-
elded in principle that Germany
and Austria will intervene in Polajid
with armed forces In case the Hi...
elan Emperor finds It impossible to
maintain *h- control of Poland, tbe
Utree^Emperors thereafter acting IB*]
concord for tbe maintenance of the
atattis quo of their respective Palish
p-osaesslonn.
This understanding amounts to a
regular holy alliance between tbe
thron Rmwroril
TELEGRAPHIC BREVITIES.
Three sh»rpcr* were taken Into
custody Wednesday by Detective-*
Smith and Burke of San Franclsco
for passing fraudulent national bank
bills. Tbey gave (be name* of Frank
McArdle, toula Dray and John Curry.
New York suffered severely from
heal lant Tuesday, aud before a refreshing shower In the afternoon
brought relief three deaths and m-v-
eral score of prostrations were reported. ^
Engineer Charles Zeebrlsl and
Fireman Griffiths were killed ami
three others seriously hurt ln a head'
on collision of oil trains. Wednesday,
on tbe Gulf, Colorado and Santa Fe
Railroad, near l-lantvraville. Tex.
Sir 'thoroaa Upton will establish
an immense packing plant In Winnipeg. Manitoba, in an effort to capture the trade with Great Britain.
The San Rafael Society for tbe
Prevention of Cruelty to Animals,
yesterday'found 148 starving horse*
on the San Clemeale ranch, neat
Corte Madera. The horses belong to
San Francisco persons, who have
placed them in pasturage, and every
one ot the anlmai* are refugees (rom
that city. There is not a bit of grass
on tbe ranch and tbey bad long ago
given up the hunt for something to
eat Flvo have already died. Arrest*
wfll probably be made.
During a violent wind and rale
Itorm yesterday at Newport News.
Va., the Norwegian turret stesm-
thlp Guernsey dragged anchor an
:r*shed. stern on. into the starboar
tide of the battleship Rhode Island,
then at anchor off Chesapeake and
Ohio pier.
Richard A. McCurdy, former President of the Mutual Ufe Insurance
Company, t* being called upon to account for about 12,000,000 of tbe
policy bolder*' money disbursed
through "yellow dogs" funds durlni
bis regime.
I1AXKEK BBOOTS HIMAKI.V.
HI He«1(lt Is Kupptxted to Be th*
Cause of His lUah Act.
De* Moines, la.. July it.—Martin
Flynn. president of the People's Savings Bank of this city, shot hlmselt
la the bead at n down town drug
store yesterday, dying almost Instantly
111 health Is the supposed ejBVM,
Mr. Flynn waa prominent through
out the West us a breeder Of *bort-
horn cattle. He also gained prominence a* a clrll engineer for (he Sania
P* Id building * tunnel which begins
1& New Mexico and ends in Colerado.
Re waa CO years ot age.
Grand Duke's Body Secretly Removed
Moscow, Julvis With lhe utmost
secrecy. In (be presence of Grand
Dukes Constantlne. Alexis, Boris aad
Dmitri, the Grand Duchess Elisabeth
and a few faithful retainer*, the
body of. Grand. Duke Sergea-v* who
was assfixHlnated here by tbe*.exple-
slbn of a bomb on February 17.
190c., and which has been resting u
* temporary vault, was last night
laterred hi Hn eryp' Q& 'be Tchusana.
LETTEK PROM RATHER AROl'SKti
KO HKKT1MKXT IX MKM.
CltRFPIELD.
Seattle. Wanh.. .'July 19.—aWhw
Mltchell and Mr*, ilaude Creffleld a* t
being examined' dally by Dr. J. V.
Loughury, who calls one or oilt.-r
connuRlng physicians to act a* *"'-
visers tn an effort to determine I -
mental rendition of the women w -
are responsible for lhe death t
George Mitchell. These examinations are being made at tn-* request
of Prosecuting Attorney' Mackintosh,
and the reports made by the physicians are being kepi a secret. It Instated, However, by Dr. Mackintosh
that no complelo report ha* been
made so far, and It Is probablc
that th>- examinations will be kept
op for some little time.
The women no conduct themselves
as to make th" determination of
their rental ■ mditlon a baffling
propocUioa. Deputy Prosecutor John
Miller ha* received a letter from O.
V Hurt, father of Mra. Creffleld. H*
states Mini be rpnnot fors-ei that It
Is bis daughter who is now taj
trouble, and says be feels In d-ity
bound to come to her assistance.
Speaking of Esther Mitchell, Mr,
Hurt slates that ih« bat no friend*
or relatives who will come to her aid.
aad that, as he believe* her to he-
demented, he will assist her a* wet!
as his daughter.
For his daughter Mr. lii.rt_a*k*
the kindness of Mr. Miller, so far aa
maklaa her life In (be County Jail
as free from unpleasantness a* poe-
slble, and urges that If ll can bo done,
she be removed from the enforced
association with tbe kind'of women
who occupy the tank with her.
U It Is possible Mr. Miller will have
this request gratified. Mr. Hurt ha*
also written to his daughter, promising that he wm aid her ln her present trouble. The woman read this
letter with a* little show of emotion as she hait treated every event
connected with her arrest.
Itogern Ordered to Pay l"p-
Boston. July 19,—A decision favorable to the plaintiff was handed
down today ln the United Stale* Circuit Court ln the case of George W.
Pepper, receiver of the Bay State*
Gas Company of Delaware, tiaalnst
Henry II. Roper*, of New York, In
the suit to recover 3,000,000 alleged to be due tbe gas company In
connection with the sale of the Boa-
ton companies. The court order*
(hat one-half of tho profit f the sale.
or II.Min.i'O-'. be turned over (o their** company by Mr. Roger*.
FarticR-le'-- Xlece In Auto Aecldent.
Liscuex. France. July 19.—While
in au(omobtle ln which were ihoma*
JC. Stlllman of New York. Mrs. Green--
way. two other women, a girl and the
chauffeur were being driven at a
high' rate of speed It crashed Into a
heavy wagon. Both vehicles were
overturned aad smashed. Stlllman
and ihe dr(yer or tbe wagon were
•terlou-tly mjnred. and Mrs. Green-
way and (he chauffeur were sHghtly
hart. They were (aken to th* ho*-
pltal here.
Will Try to Oust Hnrrinuui
New York. July 19.—Thc fight to
force Edward Harrlman to relinquish
his hold upon the Wells Fargo Coin-
pany's assets and divide them among;
the stockholders to whom tbey tot-
long. Is proceeding merrily.
TO GET PAT FOB BTU'DriXO.
Government Will Pay I'hlllpino*
While Studying Dnjjlnet-rin*;.
Washington, July 19.—The Bureau of Insular Affairs bas been advised by the Philippine Commission
of an net passed to educate students
who wilt serve the Government as
surveyors, and thus meet th* great
demand for civil engineers caused by
the extensive transfer of friar lands
and other lands for mining and
agricultural purpose*. It 1* provided
by tho act tbat each year a large
number of xtudenta is to be certifltd.
to the Bureau of Iwinds for five years
of Instruction in surveying. The sLB- ;
diii"-. are to attend the new AgTr*-
-.iltural School, or the Schoot of An*
and Trade* at Manila In*the nion.|-:x.
• mi in ihe afternoon will re,
■heir inHtru'ctton In surveying. For
'he firm year the students will be-
;mliJ 1120. After a year of school
the student* wilt be examined' fir
»!>.■«.wnK-nt as junior surveyors, and*
If they pubs and desire, to remain in
the service must *lsn a contract and
remain with (he Government for four
years more. In case the student*
leave (he service ln violation of their
contract they are to be forever
barred for promotion* under th*
Philippine Civil Servlee.
Tbls provision for edj*^tting surveyors ii believed nuc-essar'y • to" lh» *
commission because of the refusal of
American surveyors to accept employment In the Islands since tbe Panama -
canal and Irrigation works la tho
United States have created such a
great demaml for enr-nnura
Abstracts of Scientifica 2022
Get PDFThis book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference.
Conference Title: Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi
