11 research outputs found
On the design of an Ohmic RF MEMS switch for reconfigurable microstrip antenna applications
No full textThis paper presents the analysis, design and simulation of a direct contact (dc) RF MEMS switch specified for reconfigurable microstrip array antennas. The proposed switch is indented to be built on PCB via a monolithic technology together with the antenna patches. The proposed switch will be used to allow antenna beamforming in the operating frequency range between 2GHz and 4GHz. This application requires a great number of these switches to be integrated with an array of microstrip patch elements. The proposed switch fulfills the switching characteristics as concerns the five requirements (loss, linearity, voltage/power handling, small size/power consumption, temperature), following a relatively simple design, which ensures reliability, robustness and high fabrication yiel
Durability of the beneficial effect of MLC601 (NeuroAiD™) on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies
No full textBackground and Aim:
A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort.
Methods:
The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years. Blinding of treatment allocation was maintained and all subjects received standard stroke care and rehabilitation. Modified Rankin Score (mRS) and Barthel Index (BI) were assessed in-person at M3 and by telephone at M6, M12, M18, M24. Odds ratios (OR) with corresponding 95% confidence intervals (CI) for functional recovery using ordinal analysis of mRS and for achieving functional independence (mRS 0-1 or BI ≥ 95) at each time point were calculated, adjusting for age, sex, baseline National Institute of Health Stroke Scale (NIHSS), onset-to-treatment time (OTT) and pre-stroke mRS.
Results:
The 378 subjects (MLC601 192, placebo 186) included in CHIMES-E from the Philippines (mean age 60.2 ± 11.1) had more women (p < 0.001), worse baseline NIHSS (p < 0.001) and longer onset to treatment time (p = 0.002) compared to other countries. Baseline characteristics were similar between treatment groups. The treatment effect of MLC601 seen at M3 peaked at M6 with OR for mRS shift of 1.53 (95% CI 1.05–2.22), mRS dichotomy 0–1 of 1.77 (95% CI 1.10–2.83), and BI ≥ 95 of 1.87 (95% CI 1.16–3.02). The beneficial effect persisted up to M24.
Conclusion:
The beneficial effect of MLC601 seen at M3 in the Filipino cohort is durable up to two years after stroke.CHIMES and/or CHIMES-E Study Investigators: Philippines—Jose C Navarro, Herminigildo H Gan, Annabelle Lao, Alejandro Baroque II, Johnny Lokin, John Harold B Hiyadan, M Socorro Sarfati, Randolph John Fangonillo, Neil Ambasing, Carlos Chua, M Cristina San Jose, Joel Advincula, Eli John Berame, Maria Teresa Canete. Singapore—Narayanaswamy Venketasubramanian, Sherry HY Young, Marlie Jane Mamauag, San SanTay, Shrikant Pande, Umapathi Thirugnanam, Rajinder Singh, Hui Meng Chang, Deidre Anne De Silva, Bernard PL Chan, Vijay Sharma, Teoh Hock Luen. Thailand—Niphon Poungvarin, Sombat Muengtaweepongsa, Somchai Towanabut, Nijasri Suwanwela, Songkram Chotickanuchit, Siwaporn Chankrachang, Samart Nitinun. Sri Lanka—H Asita de Silva, Udaya Ranawake, Nirmala Wijekoon. Hong Kong—KS Lawrence Wong. Malaysia—Gaik Bee Eow.
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The CHIMES-E study was supported by the CHIMES Society, a nonprofit organization, and grants were received by CLHC from the National Medical Research Council of Singapore (grant numbers NMRC/1288/2011 and NMRC/1096/2006)
The effect of building-level socioeconomic status on bystander cardiopulmonary resuscitation: a retrospective cohort study
No full text10.1080/10903127.2022.2061094Prehospital Emergency Care272205-21
The Effect of Building-Level Socioeconomic Status on Bystander Cardiopulmonary Resuscitation: A Retrospective Cohort Study
No full textUnderstanding the social determinants of bystander cardiopulmonary resuscitation (CPR) receipt can inform the design of public health interventions to increase bystander CPR. The association of socioeconomic status with bystander CPR is generally poorly understood. We evaluated the relationship between socioeconomic status and bystander CPR in cases of out-of-hospital cardiac arrest (OHCA). This was a retrospective cohort study based on the Singapore cohort of the Pan-Asian Resuscitation Outcomes Study registry between 2010 and 2018. We categorized patients into low, medium, and high Singapore Housing Index (SHI) levels—a building-level index of socioeconomic status. The primary outcome was receipt of bystander CPR. The secondary outcomes were prehospital return of spontaneous circulation and survival to discharge. A total of 12,730 OHCA cases were included, the median age was 71 years, and 58.9% were male. The bystander CPR rate was 56.7%. Compared to patients in the low SHI category, those in the medium and high SHI categories were more likely to receive bystander CPR (medium SHI: adjusted odds ratio [aOR] 1.48, 95% CI 1.30–1.69; high SHI: aOR 1.93, 95% CI 1.67–2.24). High SHI patients had higher survival compared to low SHI patients on unadjusted analysis (OR 1.79, 95% CI 1.08–2.96), but not adjusted analysis (adjusted for age, sex, race, witness status, arrest time, past medical history of cancer, and first arrest rhythm). When comparing high with low SHI, females had larger increases in bystander CPR rates than males. Lower building-level socioeconomic status was independently associated with lower rate of bystander CPR, and females were more susceptible to the effect of low socioeconomic status on lower rate of bystander CPR.</p
Youth Epidemiology and Resilience (YEAR) in a student population:prevalence and predictors of mental health symptoms
Get PDFBackground: Adolescence is a pivotal developmental phase, marked by a high prevalence of mental health issues. The Singapore Youth Epidemiology and Resilience (YEAR) study aims to assess the prevalence of mental health symptoms, sociodemographic risk factors, and the protective role of resilience in a multi-ethnic, Asian school-going adolescent population. Methods: School-based adolescents aged 11-18 and their parents were invited from a stratified sample of national schools, designed to be demographically representative of the mainstream school-going population. In the screening phase, adolescents completed a battery of questionnaires including the Youth Self-Report (YSR), Child Behaviour Checklist (CBCL), and the Singapore Youth Resilience Scale (SYRESS). Thereafter, diagnostic interviews were conducted on high-risk and control participants. Data analysis was conducted to establish prevalence rates of mental health symptoms, and to examine the associations between mental health symptoms, sociodemographic factors, and resilience. Results: The final study sample consisted of 3336 adolescents and 2475 parents. Based on adolescents’ response on the YSR, 37.3%, 13.1% and 27.7% of the YEAR Study population scored in the clinical range for internalizing, externalizing and total problems respectively. Based on parents’ reporting on their children on the CBCL, 15.9%, 4.0% and 11.2% scored in the clinical range for internalizing, externalizing and total problems respectively. Sociodemographic risk factors for specific mental health symptoms were identified, including belonging to the age category of 15-16 (OR, 1.8-2.2) and those living in either a 4-, 5-room or executive flat (OR, 0.6-0.7), or in condominiums and other apartments (OR, 0.4-0.6). Total resilience scores were moderately correlated with total [rs(3334) = -.49, p <.01] and internalizing [rs(3334) = -.50, p <.01] problem scores on the YSR. Conclusion: This study illustrates the state of mental health of school-going adolescents aged 11-18. The greater prevalence of internalizing symptoms indicates the need for stronger attention for identifying internalizing problems and targeted interventions for those at risk of such symptoms. The association between mental health symptoms and resilience factors highlights the protective potential of resilience building for adolescents.</p
Screening for depressive disorders:Validation of the Patient Health Questionnaire for Adolescents (PHQ-A) in a population-based multi-ethnic Asian sample
No full textObjective: To validate the Patient Health Questionnaire for Adolescents (PHQ-A) as a screening tool for depressive disorders in multi-ethnic Asian adolescents. Methods: 323 English-speaking Singaporean adolescents completed the PHQ-A, Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL), and measures of depressive symptoms (Hamilton Depression Rating Scale), suicidality (Columbia Suicide Severity Rating Scale), adverse childhood experiences (ACES), and quality of life (Youth Quality of Life Instrument – Short Form) as part of a larger nationwide cross-sectional school-based epidemiological study. Internal consistency, construct validity, and diagnostic accuracy of the PHQ-A were evaluated. The area under the ROC curve (AUC) values for Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), and Adjustment Disorder (AD) were examined separately. Results: The PHQ-A demonstrated high internal consistency (Cronbach's α = 0.89) and was positively associated with adverse childhood experiences (ρ = 0.11, p = 0.042), suicidality (ρ = 0.43, p < 0.001), and depressive symptoms (ρ = 0.63, p < 0.001), and negatively associated with quality of life (ρ = -0.59, p < 0.001). The performance of the PHQ-A was acceptable for MDD (AUC = 0.79, 95 % CI = 0.72 - 0.85) but poorer for PDD (AUC = 0.68, 95 % CI = 0.58 – 0.77) and AD (AUC = 0.53, 95 % CI = 0.41 – 0.65). Conclusion: The PHQ-A shows acceptable psychometric properties for screening for diagnosis of MDD, but not for PDD or AD, among English-speaking Asian adolescents. A cut-off score of ≥ 10 for MDD is recommended.</p
Simple and sensitive method development and validation of Econazole in human plasma by RP-HPLC
Get PDFA simple and accurate method was developed for the validation of the Econazole using Fluconazole as internal standard with short time of 10 minutes .Optimization of chromatography technique was used during the preparation of this analysis. The method carried out using reversed phase of HPLC. Chromatography using Phenomenex Luna C18 Column (250mm x 4.6mm i.d, 5µm) as the stationary phase and mobile phase of solvent A and B of 0.5% Triethylamine at pH 6.5 and Acetonitrile at pH 3.5. Wavelength was fixed at 260nm and flow rate at 0.6mL/min. Validation studies was achieved by using the fundamental parameters, including accuracy, precision, selectivity, sensitivity, linearity and range, stability studies, limit of detection (LOD) and limit of quantitation (LOQ). Retention time obtained for Econazole and Fluconazole are 7.7 minutes and 5.18 minutes. It shows recovery at 93.5% which is more precise and accurate compared to the other Econazole method. Hence, a simple and accurate method of validation of Econazole in drug free plasma was developed and validated
Simple and sensitive method development and validation of Econazole in human plasma by RP-HPLC
Get PDFA simple and accurate method was developed for the validation of the Econazole using Fluconazole as internal standard with short time of 10 minutes .Optimization of chromatography technique was used during the preparation of this analysis. The method carried out using reversed phase of HPLC. Chromatography using Phenomenex Luna C18 Column (250mm x 4.6mm i.d, 5µm) as the stationary phase and mobile phase of solvent A and B of 0.5% Triethylamine at pH 6.5 and Acetonitrile at pH 3.5. Wavelength was fixed at 260nm and flow rate at 0.6mL/min. Validation studies was achieved by using the fundamental parameters, including accuracy, precision, selectivity, sensitivity, linearity and range, stability studies, limit of detection (LOD) and limit of quantitation (LOQ). Retention time obtained for Econazole and Fluconazole are 7.7 minutes and 5.18 minutes. It shows recovery at 93.5% which is more precise and accurate compared to the other Econazole method. Hence, a simple and accurate method of validation of Econazole in drug free plasma was developed and validated
Bone tissue engineering: harnessing interdisciplinary approaches for clinical application
No full textCorrelation study of ultrasound measurement of the anterior soft tissues of the neck and the degree of laryngoscopy in patients with a Ganzouri score greater than or equal to 4
Get PDFLa laringoscopia difícil imprevista puede tener consecuencias graves, y es una fuente significativa de morbilidad y mortalidad. Los métodos de predicción para vía aérea difícil son seriamente inexactos. Han surgido estudios que indican que las medidas específicas de ultrasonografía pueden ser predictores de laringoscopia difícil, pero su uso es todavía limitado, y no hay estudios en población colombiana.
El propósito de este estudio de tecnología diagnóstica de corte transversal es evaluar el grado de correlación entre la cuantificación ecográfica de los tejidos blandos anteriores del cuello y el grado de laringoscopia en pacientes con score de ganzouri mayor o igual a 4.
Se incluyeron 122 pacientes de edad entre 21-86 años sometidos a anestesia general con requerimiento de intubación orotraqueal. Se utilizaron análisis de correlación y análisis de curvas ROC, además de cálculo de sensibilidad, especificidad, y valores predictivos y porcentaje de observaciones correctamente clasificadas para cada valor de las distancias medidas por ecografía.
Se encontró que existe un grado muy débil de correlación entre las distancias ecográficas y el grado de laringoscopia.
La discriminación de la medida ecográfica epiglotis-piel para laringoscopia difícil fue buena, comparada con las otras medidas ecográficas en las que se obtuvieron áreas bajo la curva ROC con capacidad discriminatoria mala. Los valores predictivos, sensibilidad, especificidad, y likelihood ratio fueron bajos para las tres mediciones ecográficas.1. RESUMEN ............................................................................................................................... 6
2. DESCRIPCIÓN DEL PROYECTO ................................................................................................ 7
2.1 PLANTEAMIENTO DEL PROBLEMA ................................................................................. 7
2.2 PREGUNTA DE INVESTIGACIÓN ...................................................................................... 8
2.3 HIPÓTESIS INVESTIGATIVA ............................................................................................. 8
2.4. JUSTIFICACIÓN ............................................................................................................... 9
3. MARCO TEÓRICO .................................................................................................................. 10
4. OBJETIVOS ............................................................................................................................ 20
OBJETIVO GENERAL .................................................................................................................. 20
OBJETIVOS ESPECÍFICOS ........................................................................................................... 20
5. MATERIALES Y MÉTODOS .................................................................................................... 21
7.1 Tipo de estudio ................................................................................................................... 21
7.2 Población de referencia y muestra .................................................................................... 21
7.2.1 Población objetivo: ......................................................................................................... 21
7.2.2 Población elegible: .......................................................................................................... 21
7.3.1 Criterios de inclusión: ...................................................................................................... 21
7.3.2 Criterios de exclusión: .................................................................................................... 22
7.4 Muestreo ............................................................................................................................ 22
7.4.1 Calculo de la muestra. ..................................................................................................... 22
7.4.2 Proceso de recolección de la información .................................................................... 23
7.5 Análisis Estadístico ............................................................................................................. 25
7.5.1 Plan de análisis estadístico .............................................................................................. 25
7.6 Operacionalización de las variables ................................................................................... 26
8. CONSIDERACIONES ÉTICAS .................................................................................................. 36
10. PLAN DE DIVULGACIÓN DE DATOS .................................................................................. 40
11. RESULTADOS .................................................................................................................... 41
12. DISCUSIÓN ........................................................................................................................ 59
13. CONCLUSIONES ................................................................................................................ 61
14. BIBLIOGRAFIA ................................................................................................................... 62
15. ANEXOS ............................................................................................................................ 66
15.1 CONSENTIMIENTO INFORMADO.................................................................................. 66
15.2 INSTRUMENTO DE MEDICIÓN ...................................................................................... 69
15.3. CARTA DE APROBACION COMITÉ DE ÉTICA ................................................................ 70
15.4 CRONOGRAMA DE ACTIVIDADES ................................................................................ 71
15.4 PRESUPUESTO .............................................................................................................. 73EspecializaciónUnforeseen difficult laryngoscopy can have serious consequences, and is a significant source of morbidity and mortality. Prediction methods for difficult airway are seriously inaccurate. Studies have emerged that indicate that specific ultrasonography measures can be predictors of difficult laryngoscopy, but their use is still limited, and there are no studies in the Colombian population.
The purpose of this cross-sectional diagnostic technology study is to assess the degree of correlation between the ultrasound quantification of the anterior soft tissues of the neck and the degree of laryngoscopy in patients with a ganzouri score greater than or equal to 4.
122 patients aged between 21-86 years undergoing general anesthesia requiring orotracheal intubation were included. Correlation analysis and ROC curve analysis were used, as well as calculation of sensitivity, specificity, and predictive values and percentage of correctly classified observations for each value of the distances measured by ultrasound.
It was found that there is a very weak degree of correlation between ultrasound distances and the degree of laryngoscopy.
The discrimination of the epiglottis-skin ultrasound measure for difficult laryngoscopy was good, compared with the other ultrasound measures in which areas under the ROC curve with poor discriminatory capacity were obtained. Predictive values, sensitivity, specificity, and likelihood ratio were low for the three ultrasound measurements.Modalidad Presencia
