1,721,039 research outputs found
Immunoreactivity for p53 in human head and neck cancer may change after in vitro cisplatin exposure
No full text
Molecular interactions in the metabolism of copper and iron [Interazioni molecolari nel metabolismo del rame e del ferro]
No full textHidradenitis suppurativa in a patient with Warkany syndrome: Sustainability of adalimumab treatment
No full textMental retardation is a potential limitation to self-administration of innovative biologic treatment, which is otherwise very effective for devastating chronic inflammatory conditions, such as hidradenitis suppurativa (HS). We report our successful experience with a 34-year-old woman, who was genetically affected by Warkany syndrome, which causes intellectual disability. This patient was unable to maintain long-term antibiotic regimen and was disappointed by the limited results in her 12 years' history of painful draining fistulae and abscesses; however, she enthusiastically adhered to adalimumab 40 mg/once weekly treatment. After 52 weeks, treatment compliance is excellent, the patient is satisfied with the HS improvements, and no adverse effects have been reported
A nose for trouble.
No full textA 63‐year‐old Caucasian non‐smoker presented with
purplish, firm, slowly growing plaques on the nose,
of 20 years duration. The bigger one involved the
upper part of the nose in its entirety [Figure 1], while
there were smaller ones on the left and right cheek. All
the plaques were asymptomatic and did not worsen
after sunlight exposure. His past medical history
was unremarkable. Hematological and biochemical
parameters were within normal limits. Histological
examination revealed a diffuse mid‐dermal cellular
infiltrate composed of neutrophils, eosinophils,
plasma cells, and lymphocytes. A narrow Grenz
zone was present. In the lower part of the reticular
dermis, the mixed infiltrate was intermingled with
a massive deposition of fascicled pattern collagen
fibers and spindle cell
A case report of eccrine porocarcinoma = Porocarcinoma eccrino: caso clinico
No full textIl porocarcinoma eccrino (PCE) è un tumore cutaneo che si sviluppa dalle ghiandole sudoripare eccrine. Descritto per la prima volta
da Pinkus e Mehregan nel 1963 come “ carcinoma epidermotropico eccrino” è di rado riportato in letteratura e rappresenta lo 0,005-0,010% di tutti i tumori cutanei. Gli AA descrivono il caso relativo ad una paziente di sesso femminile, razza caucasica, di 88 anni, che ha presentato sulla coscia sinistra una neoformazione nodulare polipoide, di colore rosso-brunastro, procidente sul piano cutaneo, a base irregolarmente circolare, di consistenza duro-fibrosa, asintomatica. Tale neoformazione sarebbe insorta 15 anni prima ,accrescendosi rapidamente negli ultimi mesi. Praticata l’asportazione chirurgica in anestesia locale, l’esame istologico ha permesso di inquadrare la neoformazione come “poroma eccrino maligno insorto su poroma”. Gli AA, dopo avere riferito sul quadro clinico-istologico e dopo breve disamina della letteratura corrente, ne discutono le possibili strategie terapeutiche.Eccrine porocarcinoma (EPC) is a rare malignant skin appendage tumour deriving from the intraepithelial ductal parts of the sweat glands. First described by Pinkus e Mehregan nel 1963 as an epidermotropic eccrine carcinoma, it is rarely reported in medical literature and represents 0.005-0.01% of all skin tumors. We report a case of a 88-year-old Caucasian female presented to our Clinic with an asymptomatic, red-brown , irregularly shaped firm nodule on the left thigh aroused 15 years earlier. The lesion has been excised and histopathological examination showed an "eccrine porocarcinoma aroused on eccrine poroma". Review of the literature on this rare condition and possible therapeutic strategies are also discussed
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