1,099 research outputs found
IDEAS IN CHEMISTRY AND MOLECULAR SCIENCES: ADVANCES IN NANOTECHNOLOGY, MATERIALS AND DEVICES
No full text
Engineering 3D ordered molecular thin films by a nanoscale control
No full textThis perspective aims to report on experimental preparation and investigation tools for
engineering molecular thin films with a three-dimensional (3D) nanoscale control that is of
relevant interest for different emerging applications as well as for the development of calibration
standards. Such thin films may be obtained by man-made methods, self-assembly or
spatio-temporal self-organization and/or by the combination of these last approaches with
external tools. Understanding the main features and the physical-chemistry underlying the related
ordering phenomena is in due course and a theoretical framework is under development. In this
respect it is of fundamental importance to achieve the ability to get 3D structural images with a
nanoscale detail. This issue is at the early stage and novel techniques like electron tomography
and scanning transmission X-ray microscopy are very promising
Tomorrow’s Chemistry Today: Concepts in Nanoscience, Organic Materials and Environmental Chemistry, second edition
No full textInkjet printing methodologies for drug screening
No full textWe show for the first time a contactless, low-cost, and
rapid drug screening methodology by employing inkjet
printing for molecular dispensing in a microarray format.
Picoliter drops containing a model substrate (D-glucose)/
inhibitor (D-glucal) couple were accurately dispensed on
a single layer consisting of the enzymatic target (glucose
oxidase) covalently linked to a functionalized silicon oxide
support. A simple colorimetric detection method allowed
one to prove the screening capability of the microarray
with the possibility to assay with high reproducibility at
the single spot level. Measurements of the optical signal
as a function of concentration and of time verified the
occurrence at the solid-liquid interface of the competitive
enzymatic inhibition with a similar behavior occurring for
this system in a solution phase along with overcoming
competition effects. We propose this methodology as a
general application for drug screening purposes, since it
may be extended to any kind of enzyme-substrate/
inhibitor or ligand-target biochemical syste
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