218 research outputs found
New cytotoxic alkylbenzoquinone derivatives from leaves and stem of Ardisia kivuensis (Myrsinaceae)
No full textFive new alkylbenzoquinone derivatives, ardisiaquinones L-P (1-5) along with the known ardisiaquinone K were isolated from the MeOH extracts of leaves and stems of Ardisia kivuensis Taton (Myrsinaceae). Ardisiaquinones L, M and N were isolated from the leaves while ardisiaquinones K, O and P were obtained from the stem. Ardisiaquinone O was obtained in mixture with ardisiaquinone N, and P together with K, respectively. Their structures were elucidated on the basis of spectroscopic data. All the compounds showed cytotoxicity against Artemia salina and moderate antimicrobial activity. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved
Phytochemical Analysis of a Cytotoxic Fraction of Quassia silvestris using LC-HR-ESI-MSn
No full textIntroduction - The genus Quassia is a promising source of secondary metabolites with biological potential including antimalarial and cytotoxic activities. Limited data are available on the phytochemistry and pharmacology of Quassia silvestris Cheek & Jongkind, a Cameroonian medicinal plant used to treat various ailments. Objectives - To carry out the bioassay-guided fractionation and LC-HR-ESI-MS analyses of the leaves extract from Q. silvestris; to purify the active fractions and isolate the major compounds using different chromatographic and spectroscopic methods. The obtained compounds will be evaluated for their biological activity. Material and methods - Following the cytotoxic screening and LC-HR-ESI-MS profiling of fractions obtained from partition of the methanolic extract of Q. silvestris leaves, the CH2Cl2-soluble fraction which exhibited the highest cytotoxicity was retained for further investigations. Results - Sixteen squalene-derived metabolites were identified with oxasqualenoid derivatives being the most predominant. Among the isolates, structure elucidation of two new oxasqualenoids quassiols E (1) and F (2), were achieved by NMR (one-dimensional (1D) and two-dimensional (2D)) and MS methods. The newly characterised compounds 1 and 2, together with the known tetraol (3) and 3-oxo-oleanoic acid (16) displayed moderate cytotoxicity. Conclusion - The identification and structural characterisation of highly oxidised squalene derived metabolites from this plant may provide important insight data for further pharmacological investigations. The LC-HR-ESI-MSn method reported here could be developed as a rapid and efficient tool for the analyses of structurally related compounds in the genera Quassia, Simarouba, and Eurycoma of the subfamily Simarouboideae. Copyright (C) 2016 John Wiley & Sons, Ltd
Anthraquinones and triterpenoids from seeds of Vismia guineensis
No full textGerman Academic Exchange Service (DAAD) (Germany
Turrealabdane, Turreanone and an Antisalmonellal Agent from Turraeanthus africanus
No full textPhytochemical investigation of the seeds of Turraeanthus africanus (Meliaceae), a Cameroonian plant species traditionally used in the treatment of typhoid fever, afforded eight compounds, including two labdanes, a C-arabinoside derivative, a sesquiterpene, and several triterpenes, two of which are new: 15',16'-dihydroxy-15(12'), 15' (16')-diolidebislabd-8(17),8'(17'), 12-trien-16-al (1), trivially named turrealabdane and a C-arabinoside derivative (2), trivially named turreanone. The other compounds are 12,15-epoxylabda-8 (17), 12,14-trien-16-acetate (3), (+)-eudesmanol-O-L-arabinoside, cyclolaudenol, stigmasterol, sitosterol glucoside and lupeol. Acetylation and oxidation of turrealabdane yielded 15',16'-diacetoxyturrealabdane and 15,12'-dioxoturrealabdane-15',16'-dial, respectively. Their structures were determined by means of spectroscopic data including 1D and 2D NMR in combination with MS. The compounds were evaluated for antibacterial activities, chloramphenicol and amoxicillin being used as standard. Compound 3 was the only active principle, possessing the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of respectively 25 mu g/mL and 100 mu g/mL against Salmonella typhi, S. paratyphi A and S. paratyphi B. This compound did not show any activity against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus
Chemical Constituents, Antimicrobial and Cytotoxic Activities of Hypericum riparium (Guttiferae)
No full textBetulinic acid (1), 5-hydroxy-3-methoxyxanthone (2), 1,6-dihydroxy-7-methoxyxanthone (3), daucosterol (4), bijaponicaxanthone C (5), hypercalin C (6), 1-hydroxy-6,7-dimethoxyxanthone (7), cadensin D (8) and 5-hydroxy-1,3-dimethoxyxanthone (9) were isolated from the roots of Hypericum riparium. These compounds are reported for the first time from this plant. The extracts and two of the isolated compounds (2 and 8) exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 0.97-250 mu g/mL). In addition, the brine-shrimp (Artemia salina) lethality bioassay of compound 6 showed potent cytotoxicity with LD50 of 3.23 mu g/mL
The 18th Annual Eugene J. McCarthy Lecture
No full textThe annual public lectureship carries McCarthy’s deep commitment to the ideals and principles of democratic self-government. It seeks to inspire a new generation of young people to pursue fresh ideas, challenge the status quo, effect positive change in their communities, and, like McCarthy himself, lead with honesty, integrity, and courage.“Disagreeing Better”: the 18th Annual Eugene McCarthy Lecture on Thursday, September 19, 2024 at Saint John’s University’s Steven B. Humphy Theater. We are delighted to welcome John Inazu, Washington University law professor, First Amendment expert, and author of Learning to Disagree.
This will be an extra special evening — think C-SPAN meets Saturday Night Live — because Professor Inazu will be interviewed by Tane Danger and joined by the cast of the Theater of Public Policy, a brilliantly funny improv comedy group.
John Inazu is the Sally D. Danforth Distinguished professor of Law and Religion at Washington University in St. Louis. His latest book is Learning to Disagree: The Surprising Path to Navigating Differences with Empathy and Respect (Zondervan, 2024)
Inazu is also the author of Liberty’s Refuge: The Forgotten Freedom of Assembly (Yale University Press, 2012) and Confident Pluralism: Surviving and Thriving Through Deep Difference (University of Chicago Press, 2016). He is co-editor (with Tim Keller) of Uncommon GroundL Living Faithfully in a World of Difference (Thomas Nelson, 2020).
Inazu is the founder of the Carver Project and the Legal Vocation Fellowship, a senior fellow with the Trinity Forum, and a senior fellow with Interfaith America, where he co-directs (with Eboo Patel) the Newbigin Fellows.The Theater of Public Policy is America’s unique civics-inspired improv comedy troupe. Since 2011, they have hosted over 300 live and online shows across the U.S., blending expert interviews with witty improv performances. Covering diverse topics like housing, climate science, and gun rights, their shows are both educational and entertaining. They have featured notable guests including Vice President Elect Tim Walz, Senator Tina Smith, and Congressman Dick Gephardt. Led by Tane Danger, an improviser with a master’s in public policy, the troupe also collaborates on innovative events – from live quiz shows to virtual museum guides – where creativity meets intelligence in engaging new ways
Chemical Constituents, Antimicrobial and Cytotoxic Activities of Hypericum riparium (Guttiferae)
No full textBetulinic acid (1), 5-hydroxy-3-methoxyxanthone (2), 1,6-dihydroxy-7-methoxyxanthone (3), daucosterol (4), bijaponicaxanthone C (5), hypercalin C (6), 1-hydroxy-6,7-dimethoxyxanthone (7), cadensin D (8) and 5-hydroxy-1,3-dimethoxyxanthone (9) were isolated from the roots of Hypericum riparium. These compounds are reported for the first time from this plant. The extracts and two of the isolated compounds (2 and 8) exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 0.97-250 mu g/mL). In addition, the brine-shrimp (Artemia salina) lethality bioassay of compound 6 showed potent cytotoxicity with LD50 of 3.23 mu g/mL
The Blood on our Moon: A Celebration of Vessels
No full textThis thesis addresses the notions of home, belonging, and
foreignness, such as that experienced by diasporic people in
Aotearoa New Zealand. While the Western notion of home might
define diasporic communities as homeless, diasporic homes are
created by establishing a sense of identity through constant
translation between their multiple cultures.
The thesis investigates gecekondu neighbourhoods, Turkish
improvised self-built homes, as a case study of diasporic
communities. These discriminated, marginalised communities
express remarkable resilience via their unique architectural
typology; a strong sense of identity prevails despite being
perceived as the others in their own homelands. Constantly
collaging and translating notions of home into their selfbuilt
houses, gecekondu communities transform their houses
into homes that reflect their identities. The case study aims
to analyse how diasporic communities architecturalise these
notions of home and belonging.
The thesis proposes that ‘vessels’, belonging to or
created by diasporic beings, are architectural objects and
carriers of identity. They are the translations of their ‘Third
Space’ identities, which when collaged together develop and
embody a sense of belonging. Vessels transform the spaces
around them, extending this sense of belonging outwards to the
architectural envelope. A collage of these vessels within a
space transforms a foreign house into a new home for diasporic
people.
The project concludes in a series of crafted vessels
which reflect the author’s personal complex diasporic identity.
The vessels are created from fragments of the authors’ memories
and experiences, and embody elements of her cultural background
as a Aotearoa New Zealand born, ethnic Korean who grew up in
Turkiye. These vessels are created in an Aotearoa New Zealand
context, using locally sourced materials. When collaged together
the vessels create a space that is both familiar to Aotearoa
New Zealand, and a reflection of the authors’ ‘Third Space’
identity. As such, the space created is one in which the author
can belong.
The author suggests that this same method could inform
the way in which conventional architectural practice approaches
designing homes for diasporic communities. In doing so, the
architectural landscape of Aotearoa New Zealand can be more
representative of the nation’s rich diversity, through the
architecturalisation of diasporic identities
Selective interference: Emergent complexity informed by programmatic, social and performative criteria
No full textParametric design tools and visual programming languages are fast becoming an important part of the architects design process. A review of current literature notes that the barrier to entry into the medium is lowering while the power of the tools available is increasing. The purpose of this research is to use these emerging tools to explore complex architectural issues related to space planning and massing. This research aims to bring these aspects of the design process together to generate an architecture where programme and aesthetic are derived in equal measure by the architect and the computer.
The project began with a series of technical studies focusing primarily on space planning, massing, site analysis and circulation with the purpose of using an amalgamation of these techniques to develop into a final generative algorithm.
These ideas are explored through an open ended design process of iterative research and testing, self and peer review, development and critical reflection. The viability of the algorithm is then tested through the generation a number of test buildings, across variety of sites.
In order to provide a direction and author a degree of creative friction within the research process, the projects are framed around the development of a mid-size, urban sited secondary school.
The final algorithm provides constraints in such a way that the architecture evolves in a natural, predictable way that can still surprise and inform, as well as consistently producing viable, interesting iterations of buildings. This process, described as an “open box” structure, produced a wide variety of working concepts and provided a high level of control as a designer
Pierre Bayard et le Livre Imaginaire++. Dans la fiction des Liaisons dangereuses
No full textConférence organisée par Elise Aru, Cecile Bishop, Alex Robbins et Léa VuongInternational audienc
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