50 research outputs found
Dataset of Chemiluminescent Chemosensor-Based Assay
No full text<p>This dataset allows to analyze the results in the study of the chemiluminescent chemosensor-based assay by Nilima Manoj Kumar, Pierre Picchetti, Changming Hu, Laura M. Grimm, and Frank Biedermann.</p>
<p>When using the data, please cite the corresponding paper. </p>
Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs
No full textPoint-of-care diagnostics relies on optical and electrochemical sensors to develop devices that are both compact and cost-effective. Therefore, the search for new design principles for chemosensors that enable multiple signal outputs is a particularly interesting concept. In this work, we present an unimolecular chemosensor based on cucurbit[7]uril that combines two signal readouts - namely fluorescent and electrochemical signals - in a single chemosensor design. This is achieved by utilizing the tunable fluorescence and the electrochemical properties of the reporter molecule, which depend on whether or not it is engulfed by the cucurbit[7]uril cavity in the absence or presence of the analyte. By setting up an assay using the dual readout chemosensor, illicit drug formulations containing pancuronium bromide or nicotine can be detected at low micromolar concentrations (0–100 μM). This assay is compatible with standard fluorescence plate readers and electrochemical devices, including commercially available screen-printed electrodes. Overall, the chemosensor presented in this study represents a significant advance in the development of cucurbit[7]uril chemosensors, characterized by multimodal detection capabilities. It uniquely combines traditional optical and electrochemical detection methods in a single molecular design
Conception et préparation de particules organosilice dégradables pour des applications biomédicales
No full textThe work presented in this thesis focused on the preparation and characterization of novel stimuli-responsive organosilica particles. In this respect, a series of organoalkoxysilanes have been synthesized and used to prepare organosilicas, which possess either covalently or supramolecularly linked organic bridging-groups within their silica framework. It has been shown that porous and light-degradable and organosilicas can be prepared which are able to quantitatively release hydrophobic molecules upon light-irradiation and that oligonucleotides, such as DNA and PNA can be integrated into the particles framework in order to prepare materials, which can interact with biological molecules such as enzyme or complementary DNAs. Finally, the possibility to prepare redox-responsive cage-like organosilica particles, a novel type of morphology for organosilicas, was shown and their potential use for the development of novel nanomedicines was evaluated and discusse.Les travaux présentés dans cette thèse se sont concentrés sur la préparation et la caractérisation de nouvelles particules d’organosilice sensibles aux stimuli. À cet égard, une série d'organoalkoxysilanes ont été synthétisés et utilisés pour préparer des organosilices possédant des groupes fonctionnels organiques liés de manière covalente ou supramoléculaire dans leur structure de silice. Il a été démontré qu'il est possible de préparer des organosilices poreuses et photodégradables qui sont capables, sous irradiation lumineuse, de libérer quantitativement des molécules hydrophobes. De plus, certains oligonucléotides, tels que l'ADN et l'ANP, peuvent être intégrés dans la structure des particules afin de préparer des matériaux pouvant interagir avec des molécules biologiques telles que des enzymes ou des ADN complémentaires. Enfin, la possibilité de préparer des particules d'organosilice sous forme de cage et sensibles à l'oxydoréduction a été mis en évidence et leur utilisation potentielle pour le développement de nouvelles techniques de nanomédecine a été évaluée et discutée
[ECLIPSE]_T1_CBn-amplification_Dataset containing electrochemical and photophysical characterization of CB7-Ru
No full text
Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids
No full textSynthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host–guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems
Towards an economic theory of strikes: Further evidence from Brazilian data
No full textWe analyse the history of the labor movement in Brazil since the beginning of its industrialization, with particular emphasis on the legislation governing labor disputes. A data set on strike activity for that country during the period between 1983 and 1993 is first analysed at the descriptive level, and then used to produce results based on statistical methods of frequency and duration analysis. The obtained results of frequency and duration of strikes, including their relationships with some macroeconomic variables, are compared with ones from similar studies using data from the US and Canada. The comparison shows that there seems to be a common pattern of results in these countries. An explanation for the observed features of these patterns is then sought in the context of game-theoretic models of bargaining, and suggestions for future research in the area are given.Made available in DSpace on 2011-05-07T13:56:21Z (GMT). No. of bitstreams: 2
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