105 research outputs found
Ontogenese des profils endocriniens dans differentes situations experimentales chez le rat
No full textSIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Correction to: Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats
No full textCorrection After the publication of this article [1] it came to our attention that Harquin Simplice Foyet was incorrectly included as Harquin Simplice Harquin Foyet. The corrected name is included in the author list. The original article was updated
Effects of Pirimiphos-methyl (An Organophosphate Insecticide) on the Fertility of Adult Male Rats
No full textEffects of Pirimiphos-methyl (An Organophosphate Insecticide) on the Fertility of Adult Male Rats
No full textEffects of Propoxur on the Reproductive System of Male Rats
No full textThe reproductive toxicity of propoxur
(2-isopropoxy-phenyl-N-methylcarbamate), a carbamate pesticide, was
investigated in adult male Wistar rats exposed to 0, 1.73, 2.6, and 5.2
mg/kg body weight/day for 90 successive days. Results obtained from
this study showed a significant (p<0.05) concentration-dependent
increase in food consumption, relative weights of testis, epididymis
and kidneys with maximum effects observed at the highest dose of
propoxur (5.2 mg/kg) compared to the control. On the contrary, there
was a significant (p<0.05) decrease in the body weight gain, sperm
density, serum and intratesticular total cholesterol concentrations,
and intratesticular total proteins in rats treated with propoxur at the
dose of 5.2 mg/kg body weight. Propoxur had no significant effect on
gestation, fertility and parturition indices, average birth weight,
litter size and pups sex ratio of untreated female rats mated with
treated males rats. These results suggested that propoxur increased
food consumption, relative weight of reproductive and detoxication
organs, decreased body weight gain and sperm density per gram of cauda
epididymis without affecting the reproductive performances.Effets du propoxur sur le système de reproduction des rats
mâles La toxicité de reproduction du propoxur (2-isopropoxy)
(2-isopropoxyphenyl - N - méthylcarbamate), un pesticide carbamate
a été étudié chez les rats adultes de souche Wistar
exposés à un poids corporel de 0, 1,73; 2,6 et 5,2 mg/kg de
poids corporel par jour pendant 90 jours successifs. Les résultats
obtenus à partir de cette étude ont montré une
croissance significative dans la consommation de la (p < 0, 05)
nourriture qui dépende de la concentration, des poids relatifs de
testieules, l'épididyme et des reins. Les effets maximums ont
été remarqués au point de la dose la plus forte du
propoxur (5, 2 mg/kg) par rapport au contrôle. Par contre, il y a
eu une baisse significative (p < 0, 5) du gain de poids corporel de,
la densité du sperme, du serum et des concentrations du
cholesterol total intratesticulaire et les protein total
intratesticulaire chez les rats qui ont été traités
à l'aide du propoxur à la dose de 5,2 mg/kg de poids corporel
par rapport au contrôle. Le propoxur n'a pas eu un effet
significatif (p > 0,05) sur la gestation, les indices de la
fécondité et de la parturition, le poids de naissance moyen,
la taille de la portée et le sex-ratio des rats femelles qui n'ont
pas été traités ont croisées avec les rats
mâles traités. Ces résultats ont suggéré que
propoxur a augmenté la consommation de la nourriture, le poids
relatif des organes de reproduction et de détoxication, diminue le
gain de poids corporel et de la concentration du sperme par gramme de
queue de l'épididyme sans que cela affecte des performances de la
reproduction
Antidiabetic effects of aqueous and dichloromethane/methanol stem bark extracts of Pterocarpus soyauxii Taub (Papilionaceae) on streptozotocin-induced diabetic rats
No full textEffects of Propoxur on the Reproductive System of Male Rats
No full textThe reproductive toxicity of propoxur
(2-isopropoxy-phenyl-N-methylcarbamate), a carbamate pesticide, was
investigated in adult male Wistar rats exposed to 0, 1.73, 2.6, and 5.2
mg/kg body weight/day for 90 successive days. Results obtained from
this study showed a significant (p<0.05) concentration-dependent
increase in food consumption, relative weights of testis, epididymis
and kidneys with maximum effects observed at the highest dose of
propoxur (5.2 mg/kg) compared to the control. On the contrary, there
was a significant (p<0.05) decrease in the body weight gain, sperm
density, serum and intratesticular total cholesterol concentrations,
and intratesticular total proteins in rats treated with propoxur at the
dose of 5.2 mg/kg body weight. Propoxur had no significant effect on
gestation, fertility and parturition indices, average birth weight,
litter size and pups sex ratio of untreated female rats mated with
treated males rats. These results suggested that propoxur increased
food consumption, relative weight of reproductive and detoxication
organs, decreased body weight gain and sperm density per gram of cauda
epididymis without affecting the reproductive performances.Effets du propoxur sur le système de reproduction des rats
mâles La toxicité de reproduction du propoxur (2-isopropoxy)
(2-isopropoxyphenyl - N - méthylcarbamate), un pesticide carbamate
a été étudié chez les rats adultes de souche Wistar
exposés à un poids corporel de 0, 1,73; 2,6 et 5,2 mg/kg de
poids corporel par jour pendant 90 jours successifs. Les résultats
obtenus à partir de cette étude ont montré une
croissance significative dans la consommation de la (p < 0, 05)
nourriture qui dépende de la concentration, des poids relatifs de
testieules, l'épididyme et des reins. Les effets maximums ont
été remarqués au point de la dose la plus forte du
propoxur (5, 2 mg/kg) par rapport au contrôle. Par contre, il y a
eu une baisse significative (p < 0, 5) du gain de poids corporel de,
la densité du sperme, du serum et des concentrations du
cholesterol total intratesticulaire et les protein total
intratesticulaire chez les rats qui ont été traités
à l'aide du propoxur à la dose de 5,2 mg/kg de poids corporel
par rapport au contrôle. Le propoxur n'a pas eu un effet
significatif (p > 0,05) sur la gestation, les indices de la
fécondité et de la parturition, le poids de naissance moyen,
la taille de la portée et le sex-ratio des rats femelles qui n'ont
pas été traités ont croisées avec les rats
mâles traités. Ces résultats ont suggéré que
propoxur a augmenté la consommation de la nourriture, le poids
relatif des organes de reproduction et de détoxication, diminue le
gain de poids corporel et de la concentration du sperme par gramme de
queue de l'épididyme sans que cela affecte des performances de la
reproduction
Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models
No full textInternational audienceBackgroundHepatitis is a liver inflammation caused by different agents and remains a public health problem worldwide. Medicinal plants are an important source of new molecules being considered for treatment of this disease. Our work aims at evaluating the hepatoprotective properties of Neoboutonia velutina, a Cameroonian medicinal plant.MethodsThe aqueous extract has been prepared using phytochemical methods. HepG2 cells were used to assess anti-inflammatory properties of the extract at different concentrations. Acute hepatitis models (Carbon tetrachloride and Concanavalin A) were performed in mice receiving or not receiving, different extract doses by gavage. Liver injury was assessed using histology, transaminases and pro-inflammatory markers. Extract antioxidant and radical scavenging capacities were evaluated.ResultsThe extract led to a significant decrease in pro-inflammatory cytokine expression in vitro and to a remarkable protection of mice from carbon tetrachloride-induced liver injury, as shown by a significant decrease in dose-dependent transaminases level. Upon extract treatment, inflammatory markers were significantly decreased and liver injuries were limited as well. In the Concanavalin A model, the extract displayed weak effects.ConclusionsTaking into account underlying mechanisms in both hepatitis models, we demonstrate the extract’s radical scavenging capacity. Neoboutonia velutina displays a potent hepatoprotective effect mediated through radical scavenging properties
Efficacy of spot-spray application of Metarhizium anisopliae formulated in emulsifiable extract of Calpurnia aurea in attracting and infecting adult Rhipicephalus appendiculatus ticks in semifield experiments
No full textThe efficacy of spot-spray application of
conidia of Metarhizium anisopliae (Metsch.) Sorok. conidia formulated in an emulsifiable extract of Calpurnia
aurea (Ait.) Benth in attracting and infecting Rhipicephalus appendiculatus Neumann, 1901 ticks was evaluated
in semi-field experiments. Formulation was applied on a
900-cm2 spot and ticks released from various distances.
Attracted ticks were individually placed in glass vials to
determine the number of M. anisopliae conidia picked by
a single tick. Infected ticks were either transferred in glass
vials or maintained in the laboratory until death or
exposed to rabbits in order to investigate the effects of
fungal infection on feeding and potential reproduction
parameters. Data showed that individual ticks picked
between 3.2 and 4.1 9 105 conidia. Mortality of 83 %
was observed among ticks maintained in the laboratory
conditions. The engorgement period of fungus-infected
ticks significantly increased by 16 % compared to the
control. A significant reduction (P \ 0.0001) was recorded in body weight, egg-mass and egg hatchability from
fungus-infected females. It is therefore possible to use M.
anisopliae formulated in C. aurea extract for an integrated
pest management approach. This study showed that conidia of M. anisopliae formulated in C. aurea extract are
effective in attracting, infecting and causing mortalities of
R. appendiculatus ticks. Moreover, the reproduction performance of fungus-infected females was significantly
reduced
Hypoglycemic and antihyperglycemic effects of Abelmoschus esculentus and Alchornea cordifolia in normal and alloxan-induced diabetic rats
No full textBackground: Abelmoschus esculentus and Alchornea cordifolia are commonly used in Traditional Chinese Medicine (TCM) to treat several diseases. Abelmoschus esculentus is used to treat infertility and menorrhagia, while Alchornea cordifolia is used for the treatment of venereal diseases, cough, and diarrhoea. However, very few studies assessed the antidiabetic effects of these plants. Therefore, this study aimed to investigate the hypoglycemic and antihyperglycemic effects of aqueous extract of A. esculentus fruits and A. cordifolia leaves. Material and Methods: Fresh Abelmoschus esculentus fruits and the powder from the dried leaves of Alchornea cordifolia leaves were prepared by maceration in the aqueous phase (200 mg/100 mL and 50 mg/100 mL respectively) for 24 h, then filtered and concentrated in an oven at 45 °C. Diabete was induced to male Wistar rats by a single intraperitoneal injection of alloxan (150 mg kg−1, b.w). Rats with a blood glucose level greater than or equal to 200 mg/dL were selected, divided into groups and were daily administered orally with either aqueous extracts of A. esculentus at 30 mg kg−1 (AEAE30) or A. cordifolia at 400 mg kg−1 (AEAC400) for 14 consecutive days. For comparison, acarbose (100 mg kg−1), glibenclamide (5 mg kg−1), and 500 mg kg−1 metformin (Glucophage) were administered orally as reference drugs. Moreover, insuline was also used as a positive control and administered intraperitoneally at a dose of 5 IU/kg. Then, blood glucose levels, oral glucose tolerance test, oral maltose tolerance club, body weight and hemoglobin were assessed. For evaluation of the aqueous extracts in the intestinal transit, imodium (2mg kg−1, p.o) and fructine (5 mg kg−1, p.o) were used as a positive control to determine the spasmolytic and laxative activities, respectively. The histopathological study of the liver, kidney, pancreas, testis, epididymis, and seminal vesicle was also carried out using the hematoxyline & eosin (H&E) technique. Results: AEAE30 and AEAC400 significantly reduced (P < 0.001) fasting blood glucose (FBG) levels and significantly prevented (P < 0.001) postprandial glycemia in AI-db rats following oral glucose tolerance test (OGTT) and oral maltose tolerance test (OMTT) in alloxan-induced diabetic rats (AI-db). In normoglycemic and insulin-resistant (IR) rats, AEAE30 significantly prevented the post-prandial blood glucose level during the OGTT (P < 0.01) only in normoglycemic rats. At the end of treatment, AEAE30 significantly reduced the relative weight of the liver (P < 0.01) and significantly increased (P < 0.001) the relative weight of the testes and pancreas while AEAC400 significantly increased the relative weight of the testes compared to untreated AI-db rats. The histopathological study revealed a restoration of alloxan-induced tissue damage close to the normal control group in AI-db animals treated with plant extracts, as well as an increase in sperm density in the epididymis unlike in the untreated AI-db group. Conclusion: These findings suggested that AEAE and AEAC exhibited hypoglycemic and antihyperglycemic activities and could be therefore a useful source of antidiabetic agent
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