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The role of optical coherence tomography in clarifying the mechanisms for dobutamine stress echocardiography-induced takotsubo cardiomyopathy. [Echocardiography. 2013]
The role of optical coherence tomography in clarifying the mechanisms for dobutamine stress echocardiography-induced takotsubo cardiomyopathy.
Fineschi M, D'Ascenzi F, Sirbu V, Mondillo S, Pierli C.
Echocardiography. 2013 May; 30(5):E121-4. Epub 2013 Jan 11.Dobutamine stress echocardiography and Takotsubo syndrome: could milder forms of this pathology confound the diagnostic value of the test? [Echocardiography. 2013
Preliminary Observations on the ultrastructural modifications of the freeze-cleaved circulating platelets surface in hypercholesterolemic rabbits treated with AD6
No full textCirculating platelets show on their surface some "protuberances" placed among the plasma-membrane particles when examined with FE technique. Statistic tests have shown the significant difference in the average number of such protuberances between platelets of hypercholesterolemic and normocholesterolemic rabbits. After i.v. administration of AD6 (a substance with supposed anti-aggregating action) the number of the "protuberances" of circulating platelets of the hypercholesterolemic rabbits approaches to the average value of the normocholesterolemic ones. An interpretation of such plasma-membrane protuberances is proposed. © 1978 The Italian Pharmacological Society
How should I treat pulmonary arteriovenous malformations in a patient with Rendu-Osler disease presenting with transient ischaemic attack
No full textAbstract
BACKGROUND: A 42-year-old man with no cardiovascular risk factors or history was admitted for evaluation of an episode of transient ischaemic attack (TIA). He had no cardiovascular risk factors and his physical examination was unremarkable. INVESTIGATION: Physical examination, electrography, transesophageal echocardiogram, coronary angiogram. DIAGNOSIS: Intrapulmonary shunting, in the presence of arteriovenous malformations, possible hereditary haemorrhagic telangectasia. TREATMENT: Transcatheter occlusion of multiple pulmonary arteriovenous malformations using an AMPLATZER vascular plu
The role of optical coherence tomography in clarifying the mechanisms for dobutamine stress echocardiography-induced takotsubo cardiomyopathy
No full textTakotsubo cardiomyopathy is a clinical disorder characterized by a transient dilatation and akynesis or dyskinesis of the left ventricular (LV) apex, mimicking an anterior wall acute myocardial infarction in the absence of significant coronary artery disease (CAD). It typically occurs during an episode of severe emotional or physical stress. Recent reports suggested the potential of dobutamine stress echocardiography (DSE) in inducing the aforementioned syndrome. The transient dysfunction of the LV does not fit any known coronary distribution. Furthermore, there is no obstructive CAD demonstrated at angiography to account for the observed dysfunction. Consequently, the pathophysiology of this syndrome is still undetermined. Here, we report a case of DSE-induced Takotsubo cardiomyopathy in which high-resolution intracoronary imaging was utilized to exclude possible vessel alterations to help provide potential mechanistic explanations for the development of this conditio
Subocclusion of the sinus node artery during coronary angioplasty: arrhythmological considerations
No full textWe report the case of a 58-year-old man who developed atrial fibrillation as a result of iatrogenic subocclusion of a diseased sinus node artery, originating from the left circumflex artery (LCx), occurring during LCx stenting, suggestive of an ischemic etiology of sinus node dysfunctio
Modifications of the freeze-cleaved circulating platelet membrane in hypercholesterolemic rabbits, prevented by AD6
No full textCirculating platelets present on their membrane some protuberances, placed among the plasma-membrane particles, when examined with F.E. technique. Statistic tests have shown a significant increase in the average number of such protuoerances in the platelets of hypercholesterolemic (15 - and 45 days) rabbits.
After i.v. administration of AD (8-mono-chloro carbochromen, a substance with a supposed anti-aggregaging action) the number of the protuberances of circulating platelets in the hypercholesterolemic rabbits approaches to the average values of the normocholesterolemic ones
Pulmonary hypertension in idiopathic pulmonary fibrosis: prevalence and clinical progress
No full textThe aims of the present study are to define the prevalence of pulmonary hypertension (PH) in a cohort of idiopathic pulmonary fibrosis (IPF) patients, to investigate any correlations between systolic pulmonary artery pressure (PAPs) and functional data, to evaluate clinical progress and to compare long-term survival in IPF patients with and without PH. A population of 126 IPF patients was recruited. A high prevalence of PH (39.7%, 50/126), evaluated by echocardiography on the basis of PAPs greater than 36 mmHg, was mainly observed in smokers and female patients. Regression analysis revealed a significant correlation between PAPs greater than 50 mmHg and DLCO/VA (p = 0.0294). Mean PAPs was significantly greater one year after onset of PH (p = 0.01). 11/21 patients with FVC less than 50% had a significant increase in PAPs one year after onset of PH (p = 0.02). There was a highly significant difference between survival of IPF patients with and without PH (p = 0.0001; hazard ratio = 3.56). This study revealed that PH has a high prevalence in patients with IPF and is associated with increased risk of mortality. Early diagnosis of IPF patients with pulmonary hypertension is important, so that they can be enrolled in waiting lists for lung transplant as soon as possible
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