2,013 research outputs found
Mould. Il progetto editoriale generatore di idee
No full textL'articolo introduce e descrive il progetto editoriale Mould, iniziato da Alessio Cancellieri e Jonathan Pierini nel 2014, con particolare riferimento ai numeri 1 e 2 rispettivamente co-curati da Cancellieri e Pierini con Markus Miessen e Joan Fontcuberta
Mould 2: (Photo) Writing Degree Zero
No full textMould is a platform for transdisciplinary investigation, which aims to interpret the complexity of contemporary culture by stimulating a dialogue between its multiple forms and contaminations. We believe that the mould, embracing the notions of imprint and tracing, conveys our view of cultural press: a place to record the existing, make it circulate, generate new ideas. Mould is a project by Alessio Cancellieri and Jonathan Pierini, published by Mould Press. A. C
Mould 1: Cultures of Assembly
No full textMould is a platform for transdisciplinary investigation, which aims to interpret the complexity of contemporary culture by stimulating a dialogue between its multiple forms and contaminations. We believe that the mould, embracing the notions of imprint and tracing, conveys our view of cultural press: a place to record the existing, make it circulate, generate new ideas. Mould is a project by Alessio Cancellieri and Jonathan Pierini, published by Mould Press. A. C
Decadal variability of the Kuroshio Extension: the response of the jet to increased atmospheric resolution in a coupled ocean–atmosphere model
No full textThe Kuroshio Extension (KE) shifts between elongated and convoluted states on interannual to decadal time scales. The nature of this low frequency variability (LFV) is still under debate since it is known to be driven by intrinsic oceanic mechanisms, but it is also synchronized with the Pacific Decadal Oscillation (PDO). In this analysis we present the results from two present-climate coupled simulations performed with the CMCC-CM2 model under the CMIP6 HighResMIP protocol and differing only by their atmospheric component resolution. The impact of increased atmospheric resolution on the KE LFV is assessed inspecting several aspects: the KE bimodality, the large-scale variability and the air–sea interactions. The KE LFV and the teleconnection mechanism that connects the KE and the PDO are well captured by both configurations. However, higher atmospheric resolution favors the occurrence of the elongated state and leads to a more realistic PDO representation. Moreover, both simulations qualitatively capture the signatures of atmosphere-driven and ocean-driven regimes over the North Pacific Ocean, even if the higher resolution induces an excessively strong ocean–atmosphere coupling that leads to an overestimation of the air–sea feedbacks. This work highlights that the small scale atmospheric variability (resolution lower than 1°) does not substantially contribute to improve the realism of the KE LFV, but causes significant differences in the air–sea interaction over the KE region likely related to the strengthening of the coupling. The eddy-permitting ocean resolution shared by both configurations is likely responsible for the degree of realism exhibited by the simulated KE LFV in the two analyzed simulations
Usefulness of cytologic criteria in ultrasound-guided fine-needle aspirates from subcentimeter canine mammary tumors
No full textWe determined cytologic features of histologically confirmed subcentimeter canine mammary tumors (CMTs) to determine reasonable criteria for an accurate cytologic diagnosis. Fifty-three CMTs from 28 bitches were included. All cytologic samples were collected by ultrasound-guided fine-needle aspiration biopsy, stained with May-Grünwald/Giemsa, and retrospectively evaluated using a scoring system established for 18 cytologic features. Mean nuclear area (MNA) was also measured for each sample by a computer-assisted program. Based on the histologic diagnosis, CMTs were divided into 2 groups: malignant tumors (25) and benign lesions (15). Data were statistically analyzed using Fisher and Mann-Whitney tests. Chromatin pattern ( p < 0.05) and macrophage infiltration ( p < 0.05) were significantly different between the groups. Median MNA was significantly ( p < 0.05) larger in malignant tumors. The evaluation of these cytologic features in subcentimeter CMTs may increase the sensitivity of cytology. les
Safety and Efficacy of intraoperative Electrochemotherapy of soft tissue sarcoma in 26 dogs
No full textSoft Tissue Sarcomas (STS) represent 15% of all skin and subcutaneous tumours in dogs. Local tumour control with wide margins surgery or a combination of surgery and radiation therapy is the standard of care in the management of these tumours. Electrochemotherapy (ECT) is a local ablative technique for the treatment of locally invasive tumours.
The aim of this study is to evaluate the safety and efficacy of intraoperative ECT in the treatment of STS in dogs.
Twenty-six dogs with a diagnosis of STS were enrolled. All dogs were treated with cytoreductive surgery with very narrow or zero margins and intraoperative electrochemotherapy coupled with systemic bleomycin. Local toxicity, tumour recurrence rate and disease free interval (DFI) were evaluated.
Most tumours were grade II (15/24), and most commonly located to the limbs (19/26). Tumour size ranged from 2 to 15 cm (median 4.75 cm). Median follow-up period was 422.5 days (range 8-1297). Treatment toxicity was well tolerated in 62% of cases (16/26 had toxicity score ≤2 in a scale of 5 as maximum) and was not associated with tumour grade, tumour size, pulse frequency and pulse voltage.
Nine dogs died during the study period, three had tumour recurrence, which was the reason for euthanasia in two cases. Of the other 17 dogs, three had tumour recurrence and in one case the limb affected was amputated as rescue treatment. Overall, tumour recurrence rate was 23% (6/26). Recurrence rate was not associated with tumour grade, anatomical site, tumour size, pulse frequency and pulse voltage. For all dogs, median DFI was not reached. For dogs with tumour recurrence, mean DFI was 240 days (range 26-1025).
Intraoperative electrochemotherapy coupled with systemic bleomycin has been well tolerated but its overall efficacy needs further investigations
Nucleated Erythrocytes and Anemia in Dogs with Systemic Inflammatory Response Syndrome: Could They Affect Outcome?
No full textDuring Systemic Inflammatory Response Syndrome (SIRS) a release of inflammatory mediators
occurs and hematological modifications are common. The study’s aim was to evaluate anemia
and nucleated RBC (NRBCs) in canine SIRS compared to the severity of illness and outcome.
This retrospective study included the following dogs: 90 with SIRS, 50 healthy, 50 with
chronic diseases. SIRS grading was based on how many criteria were fulfilled. APPLEfast score
was allocated in SIRS dogs. Mortality rate was assessed at 7 and 15 days after admission.
Hemolytic or hemorrhagic disorders were excluded. SIRS grading and APPLEfast score groups
were compared to the outcome. Types of anemia and NRBCs counts were evaluated in three
study populations and to the outcome.
APPLEfast scores >25 (p=0.03) and SIRS grading >2 (p=0.001) were associated with poor
outcome. In SIRS group, anemia was present in 56/90 dogs. The most frequent types of anemia
were mild (45%) or moderate (43%), microcytic (55%) or normocytic (41%), and normochromic
(93%). Anemia and its severity were associated with poor outcome (p=0.0197). SIRS group
showed worse anemia patterns than the other two groups (p<0.001). The presence of NRBCs
occurred in 22/90 of SIRS dogs and was associated with poor outcome (p=0.005). NRBCs count
were significantly higher in the SIRS group than healthy dogs (p=0.0007).
Mild-moderate, micro-normocytic normochromic anemia is a frequent finding in canine
SIRS. Our results suggest that circulating NRBCs and their amount could be an additional
negative prognostic value
Electrochemotherapy with intravenous bleomycin for treatment of Feline Squamous Cell Carcinoma: Experience in 12 cats
No full textThe aim of this study was to evaluate the efficacy and safety of neoadjuvant electrochemotherapy (ECT) with intravenous bleomy- cin for the treatment of skin squamous cell carcinoma (SCC) of the head in cats
Soft tissue sarcoma in dogs: a treatment review and a novel approach using electrochemotherapy in a case series Soft tissue sarcoma
No full textCanine soft tissue sarcomas (STSs) are locally invasive mesenchymal neoplasms. Electrochemotherapy (ECT) is an antitumour local ablative treatment that uses electric pulses to enhance the intracellular delivery of cytotoxic drugs. The aim of this retrospective study was to review the current treatment for STSs and to evaluate the efficacy and safety of ECT with bleomycin in canine STSs. Fifty-two dogs with 54 STSs were included. Three groups were arranged: (1) ECT alone, (2) intra-operative ECT, and (3) adjuvant ECT. Signalment, tumour size, location, histological grade and margins, and ECT parameters were collected. Recurrence rate (RR), and disease-free interval (DFI) were calculated. Treatment toxicity was assessed using a 6-point scale. STSs were mostly located on limbs (77.8%). Median tumour size was 4.3 cm (range 0.4-17.0 cm). Most STSs were grade I (47.7%) and II (50.0%) and histological margins were incomplete in 94.5% of cases. Two complete remissions, one partial remission and one stable disease were recorded in group 1. Group 2 and 3 were similar for tumour location, size and grade, histological margins, treatment toxicity, pulse frequency and voltage. Moreover, RR and DFI were similar between group 2 and 3 (23% and 25%, 81.5 and 243 days, respectively). Local toxicity post ECT was mild (score ≤2) in 66.7% of cases. Higher toxicity score was associated with higher pulse voltage (1200 V/cm vs. 1000 V/cm) (p=0.0473). ECT coupled with bleomycin resulted safe and efficient in tumour local control and should be considered as an option for treatment of canine STSs
Pannicolite e miosite granulomatosa sterile idiopatica in un cane con concomitante Leishmaniosi oculare localizzata
No full textUn Bassotto veniva sottoposto a terapia immunosoppressiva
corticosteroidea inizialmente
per sialoadenite granulomatosa bilaterale aspecifica,
poi per pannicolite granulomatosa sterile,
infine per miositi granulomatose sterili fino
alla decisione di mantenere un dosaggio minimo
efficace di metilprednisolone. Nel periodo
di osservazione il cane presentava leucopenia e
linfocitopenia. Il mantenimento di corticosteroidi
alla dose minima efficace permetteva di
mantenere la malattia in remissione. Durante la
terapia il paziente sviluppava una forma di Leishmaniosi
in sede oculare responsiva al trattamento
eziologico
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