164,369 research outputs found
Evaluation of the impact of a care pathway for femoral neck fracture. (Paper presented at Communications to the British Geriatrics Society Autumn Meeting, 17th-18th October 2002, London)
No full textDoes the use of a constraint mitten, to encourage use of the hemiplegic upper limb, improve arm function in adults with sub-acute stroke?
No full textObjective: To evaluate the effect of a constraint mitten, worn on the unaffected upper limb, on the arm and hand function of participants with hemiplegia. To estimate the sample size for a future trial. Design: An A-B-A design. Setting: Inpatient, outpatient and domiciliary setting. Subjects Ten participants with mild to moderate residual upper limb hemiparesis, between 1 and 12 months post stroke. Intervention: Following a two-week baseline period, 10 participants were advised to wear the constraint mitten on the unaffected upper limb for 9 waking hours/day for two weeks to encourage use of the hemiplegic arm. Existing levels of therapy continued during the whole study. Main measures: The primary outcome measure was the Action Research Arm Test. At the end of the intervention phase participants completed a questionnaire. Participants also recorded their daily use of the constraint mitten during the intervention phase. Results: A mean improvement in the Action Research Arm Test score of 4.0 points (95% confidence interval 1.7 to 6.2; P=00.016) was found during the intervention phase after correcting for background recovery. Mean compliance was 6.7 hours/day (74%), 90% of participants were positive about the intervention and would recommend the treatment to other stroke survivors, although 50% were relieved to stop the mitten-wearing phase. Conclusions: The use of a constraint mitten in upper limb stroke rehabilitation may be a useful adjunct to enhance functional recovery with minimal additional resources. The positive findings from this preliminary study warrant a larger randomized controlled trial of 200 participants in total. <br/
Pickering, R, QX13977
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/410790Surname: PICKERING. Given Name(s) or Initials: R. Military Service Number or Last Known Location: QX13977. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 12107.226504
Item: [2016.0049.43057] "Pickering, R, QX13977
Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo
No full textThe 5'-untranslated region of Bag-1 mRNA contains an internal ribosome entry segment (IRES) and the translation of Bag-1 protein can be initiated by both cap-dependent and cap-independent mechanisms. In general, cellular IRESs require non-canonical trans-acting factors for their activity, however, very few of the proteins that act on cellular IRESs have been identified. Proteins that interact with viral IRESs have also been shown to stimulate the activity of cellular IRESs and therefore the ability of a range of known viral trans-acting factors to stimulate the Bag-1 IRES was tested. Two proteins, poly r(C) binding protein 1 (PCBP1) and polypyrimidine tract binding protein (PTB), were found to increase the activity of the Bag-1 IRES in vitro and in vivo. The regions of the Bag-1 IRES RNA to which they bind have been determined, and it was shown that PCBP1 binds to a short 66 nt section of RNA, whilst PTB interacts with a number of sites over a larger area. The minimum section of the RNA that still retained activity was determined and both PCBP1 and PTB interacted with this region suggesting that these proteins are essential for Bag-1 IRES function.<br/
P. VALERY, Cahiers 1894-1914.
No full textEdizione diplomatica integrale dei Cahiers di Paul Valéry realizzata a partire dai manoscritti depositati presso la Bibliothèque Nationale de France. Si tratta di un'edizione genetica condotta dall'équipe "Paul Valéry" dell'Institut des Textes et Manuscrits Modernes del CNRS/ENS. L'équipe è diretta da Nicole Celeyrette-Pietri e da Robert Pickering
A critical review of the effectiveness of environmental assessment and modification in the prevention of falls amongst community dwelling older people
No full textIntroduction: The potential of environmental assessment and modification to reduce falls has recently received attention within the gerontology literature. Research investigating the clinical effectiveness of this intervention in falls prevention reports conflicting results. Discrepancies are due to variation in the risk profile of study participants and the health care background of the person providing the environmental intervention or the intensity of the intervention provided.Method: The purpose of this paper is to compare and contrast two systematic reviews, which include meta-analyses, of environmental interventions for falls prevention in community dwelling older people, using the critical appraisal skills programme tool for systematic reviews. Findings: Both reviews found that: environmental assessment and modification was effective in falls prevention; intervention was effective with high but not low risk participants; and that high intensity environmental assessment was effective, whereas low intensity intervention was not. Environmental interventions which were delivered by occupational therapists were deemed high intensity, probably because their underpinning theoretical frameworks focus on the impact of the environment on function.Conclusion: We discuss possible reasons why occupational therapist led environmental assessment and modification is clinically effective in falls prevention, for people at high risk of falls, whereas non occupational therapist led intervention is not
Algoplus®Scale in Older Patients with Dementia: A Reliable Real-World Pain Assessment Tool
No full textPain is still a neglected clinical issue in elderly people with dementia and/or communicative disorders, with an unacceptable higher rate of under diagnosis and under treatment. Cognitive deficit and emotional and psychological disturbances entangle pain symptoms, affecting patient self-report. So far, observational pain tools do not have fully adequate clinimetric properties and quality requirements for easy-to-use daily rating. Older patients with dementia represent a clinical challenge. The assessment of pain is important for improving clinical outcomes, such as functional status, frailty trajectories, comorbidity, and quality of life. The PAINAID scale appears to be the most accurate pain tool in people with dementia along with the Algoplus (R) scale, a recently developed tool to rapidly assess acute pain in hospitals settings. The present study aimed to assess the clinimetric properties of the Algoplus (R), as compared to PAINAID, for detecting acute pain in a real-world cohort of hospitalized older patients with dementia
Predicting people with stroke at risk of falls
No full textBackground: falls are common following a stroke, but knowledge about predicting future fallers is lacking.Objective: to identify, at discharge from hospital, those who are most at risk of repeated falls.Methods: consecutively hospitalised people with stroke (independently mobile prior to stroke and with intact gross cognitive function) were recruited. Subjects completed a battery of tests (balance, function, mood and attention) within 2 weeks of leaving hospital and at 12 months post hospital discharge.Results: 122 participants (mean age 70.2 years) were recruited. Fall status at 12 months was available for 115 participants and of those, 63 [55%; 95% confidence interval (CI) 46–64] experienced one or more falls, 48 (42%; 95% CI 33–51) experienced repeated falls, and 62 (54%) experienced near-falls. All variables available at discharge were screened as potential predictors of falling. Six variables emerged [near-falling in hospital, Rivermead leg and trunk score, Rivermead upper limb score, Berg Balance score, mean functional reach, and the Nottingham extended activities of daily living (NEADL) score]. A score of near-falls in hospital and upper limb function was the best predictor with 70% specificity and 60% sensitivity.Conclusion: participants who were unstable (near-falls) in hospital with poor upper limb function (unable to save themselves) were most at risk of falls
Impacts of hunter-gatherers on the vegetation history of the eastern vale of pickering, Yorkshire
No full textResearch is undertaken into the vegetation and human impact at three previously un-researched archaeological sites from the eastern Vale of Pickering. The vegetation history is reconstructed from the end of the Windermere Interstadial c. 13,000 (^14)C yr BP until the final Mesolithic c. 5100 (^14)C yr BP. The early Mesolithic human impact on the vegetation is assessed using a three stage statistical test to establish the internal variability in the data as well as background variations in pollen output. The results reveal that humans had a small but significant impact on the vegetation around two of the sites. Pollen preservation at the third site precluded analyses of the impacts of humans on the vegetation. The three-stage test used to test for human impact was quite successful but requires revision before any further use. On the whole the tests confirmed the findings of conventional human impact analyses. During the pre-Holocene fires occurred on a regular basis. These fires varied in location and intensity, suggesting that some of the fires were regional or large-scale, whilst others were small and very localized. A multi-causal explanation has been given for the fires. Later, during the early Mesolithic, human groups are thought to have burnt the reedswamp at the lake edges as part of an economic strategy. Star Carr is the only site that demonstrates clearance of significant areas of woodland. During the later Mesolithic the hunter-gatherers have a greater impact on the vegetation within the Vale. This is attributed to the need for more resources as a result of vegetation change and increased population levels. Unlike their counter-parts from the North York Moors, the occupants of the lowland Vale of Pickering cause no long-term change to their environment
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
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