9,618 research outputs found
1983-1984: Kingdom Come
No full textForeground: James Pickering as Ellefstolen Harstad and Alan Brooks as Ola Enderssen (lying). Center: Rose Pickering as Gro Enderssen (seated) and Ellen Lauren as Kaja Ansen (standing). Background: EnsembleKingdom Come;Grayscal
1983-1984: Kingdom Come
No full textFrom left: Daniel Mooney as Kal Ansen, Ellen Lauren as Kaja Ansen, Rose Pickering as Gro Endressen, and Alan Brooks as Ola EndressenKingdom Come;Grayscal
1981-1982: Secret Injury, Secret Revenge
No full textAlan Brooks as Don Juan (foreground) and James Pickering as Don LopeSecret Injury, Secret Revenge;Grayscal
A comparison of different ways of including baseline counts in negative binomial models for data from falls prevention trials
No full textA common design for a falls prevention trial is to assess falling at baseline, randomize participants into an intervention or control group, and ask them to record the number of falls they experience during a follow-up period of time. This paper addresses how best to include the baseline count in the analysis of the follow-up count of falls in Negative Binomial (NB) regression. We examine the performance of various approaches in simulated datasets where both counts are generated from a mixed Poisson distribution with shared random subject effect. Including the baseline count after log-transformation as a regressor in NB regression (NB-logged) or as an offset (NB-offset) resulted in greater power than including the untransformed baseline count (NB-unlogged). Cook and Wei's Conditional Negative Binomial (CNB) model replicates the underlying process generating the data. In our motivating dataset, a statistically significant intervention effect resulted from the NB-logged, NB-offset and CNB models, but not from NB-unlogged, and large, outlying baseline counts were overly influential in NB-unlogged but not in NB-logged. We conclude that there is little to lose by including the log-transformed baseline count in standard NB regression compared to CNB for moderate to larger sized datasets
Fabrication of edible biocompatible carbohydrate particle-based Pickering emulsions
No full textDifferent from conventional emulsions, Pickering emulsions are stabilized by interfacially-adsorbed solid particles. Pickering emulsions have gained great interest in the past decades due to their high stability against coalescence, Ostwald ripening, and the possibility to avoid the deleterious effects linked to emulsifiers used in conventional emulsions. To fulfill the strong market trend of formulating products that are not only edible in theory, but also maintain the consumer perception of being natural, “clean label” and “green”, this study was dedicated to developing particles from biomass-based resources to form Pickering emulsions with potential application in food, cosmetic and pharmaceutic products. As a simple, organic solvent-free process, media-milling was applied to modify two major biomass materials, native starch and cellulose. Three maize starches (normal maize starch, high-amylose maize starch and waxy maize starch) with different amylose/amylopectin ratios were physically modified through media milling process to form milled starch particles. The physiochemical properties of these starches during milling process, including particle size, crystallinity and gelatinization properties were studied. Emulsions stabilized by milled starch particles with different amylose/amylopectin ratios exhibited significant difference in terms of stabilization capability and rheological properties. Milled high-amylose maize starch particles have the best stabilization ability, followed by milled normal maize starch particles. Furthermore, the stabilization capacity of the milled starch particles improves with the increase of milling time. To investigate the feasibility of Pickering emulsions stabilized by milled starch as a novel food-grade formulation for encapsulation and delivery of lipophilic bioactive compounds, curcumin was selected as model delivery target and encapsulated in the oil phase of Pickering emulsion. The digestion profile of curcumin-loaded Pickering emulsion was studied using three in vitro digestion models, simulated static small intestinal digestion model, pH-stat lipolysis model and TNO’s gastrointestinal model (TIM-1). Simulated static small intestinal digestion model and pH-stat model indicated that the bioaccessibility of curcumin encapsulated in Pickering emulsion was enhanced compared with free curcumin suspended in bulk oil phase. A significant improvement of curcumin bioaccessbility was also observed in an emulsion system vs in bulk oil when using TIM-1 model, which simulates the entire human GI tract. Overall, the study's findings showed that curcumin encapsulated in Pickering emulsion stabilized by milled starch possesses benign stability against harsh gastric conditions as well as improved dissolution profiles in small intestinal tract. All are suggested that Pickering emulsion stabilized by milled starch exhibit high potential as encapsulate and delivery system for lipophilic bioactive compounds. Milled cellulose particles of sizes ranging from 38 nm to 671 nm with rod-like shapes have also been successfully fabricated using media milling. Media milling process led to a notable decrease in the particle size and crystallinity of milled cellulose particles with the increase of milling time. The milled cellulose particles were irreversibly adsorbed at the oil/water interface and formed stable emulsions with droplet size around 60~42 µm, which exhibited benign stability over a month storage. Milled cellulose stabilized emulsions also exhibited good stability against a wide range of pH (3, 5, 7, 9) and salt conditions (0.1~100 mM) with slight change in the droplet size. The rheological tests indicated the formation of gel network in the emulsions, which promoted the stability of the emulsions. The in vitro digestion profile and phase behavior of Pickering emulsions stabilized by milled cellulose were evaluated to investigate their feasibility for encapsulation and delivery of lipophilic bioactive compounds. Curcumin encapsulated in Pickering emulsions exhibited benign stability with less than 50% degraded after storage of 30 days. The digestion behavior of emulsions under simulated small intestinal conditions was characterized using a pH-stat lipolysis model. The digestion profiles of emulsions were markedly dependent on the type of lipid and digestion buffer employed in lipid digestion experiments. The rate and extent of lipolysis of emulsions with medium chain triglycerides (MCT) was greater than emulsions with long chain triglycerides (soy bean and canola oil), reaching complete hydrolysis during lipolysis process independent of bile salt and phospholipids concentration. The structure changes of emulsions during digestion were analyzed using optical and fluorescent imaging. Although the initial digestion rate of curcumin encapsulated in Pickering emulsions with soy bean and canola oil was slower than the corresponding conventional emulsions stabilized by Tween/Span, their total extent of lipolysis was higher than that of conventional emulsions under both fasted and fed intestinal digestion conditions. The bioaccessibility of curcumin encapsulated in Pickering emulsions was higher than in corresponding surfactant stabilized conventional emulsions. High-amylose maize starch with different fatty acids (C12:0, C14:0, C16:0, C18:0, C18:1) were complexed using two heat-moisture methods. The structure properties of different starch-fatty acid complexes, including size and shapes of nanoscale supramolecular structures formed, through heat and moisture treatment, were studied. Optical microscope and SEM analysis showed that starch-fatty acid complexes retained the Maltese cross and granular morphology of native starch. X-ray diffraction revealed the crystalline morphology of starch-fatty acid complexes with B- and V-type crystallinity. And the crystallinity of the complexes varied depending on the fatty acids and methods used. USAXS/SAXS experiments demonstrated that fatty acid chain length and level of saturation affected both the lamellar structure as well as the B-type crystalline of the complexes. Moreover, the processing methods also exhibited major influence on the nanostructure of complexes. The resistance of these starch complexes against enzymatic hydrolysis was increased based on the in vitro digestion measurements. And the hydrophobicity of these complexes was enhanced. This was manifested by increased contact angles. The capacity of these starch-fatty acid complexes to form Pickering emulsions was characterized. Starch-saturated fatty acid complexes were able to form stable emulsions that endured heat treatment of 60, 80 and 100℃. However, starch-unsaturated fatty acid complexes could not form stable emulsions. The barrier properties of these emulsions could be adjusted by heat treatment, which led to swelling of starches. Lipolysis profile of PMFs loaded emulsions suggested that certain heat treatment could reduce the accessibility of lipase towards oil droplets and release of PMFs during lipolysis by enhancing the coverage of granules onto the oil-water interface. In conclusion, particles derived from biomass resources starch and cellulose have been successfully fabricated to form Pickering emulsions using simple, environmental-friendly procedures. The resulting formulations were edible, ‘green’, have exhibited exceptional stability and a practical potential to encapsulate and control release of lipophilic ingredients, making them suitable for various applications in cosmetic, food and pharmaceutical industry.Ph.D.Includes bibliographical referencesby Xuanxuan L
1981-1982: A Christmas Carol
No full textThe Cratchit Family.
From left: Charmaine Underheim as Marta (standing), Mark Kujawa as Ned, Jena C. Berg as Belinda, Dori Lange as Dorritt, James Pickering as Bob Cratchit, Kris Alan Kalb as Peter, and Rose Pickering as Mrs. CratchitA Christmas Carol;Grayscal
1983-1984: Kingdom Come
No full textStanding, from left: James Pickering as Ellefstolen Harstad and Tobias Anderson as Parson Dagsrood.
Kneeling: Daniel Mooney as Kal Ansen and Ellen Lauren as Kaja Ansen. Seated: Alan Brooks as Ola Enderssen, Rose Pickering as Gro Enderssen, Peter Lohnes as Thomas Ansen, Peter Rybolt as Jens Ansen, and Robert GrossmanKingdom Come;Grayscal
Alan Moore Comics as Performance, Fiction as Scalpel
No full textEclectic British author Alan Moore (b. 1953) is one of the most acclaimed and controversial comics writers to emerge since the late 1970s. He has produced a large number of well-regarded comic books and graphic novels while also making occasional forays into music, poetry, performance, and prose. In Alan Moore: Comics as Performance, Fiction as Scalpel , Annalisa Di Liddo argues that Moore employs the comics form to dissect the literary canon, the tradition of comics, contemporary society, and our understanding of history. The book considers Moore's narrative strategies and pinpoints the main thematic threads in his works: the subversion of genre and pulp fiction, the interrogation of superhero tropes, the manipulation of space and time, the uses of magic and mythology, the instability of gender and ethnic identity, and the accumulation of imagery to create satire that comments on politics and art history. Examining Moore's use of comics to scrutinize contemporary culture, Di Liddo analyzes his best-known works-- Swamp Thing, V for Vendetta, Watchmen, From Hell, Promethea , and Lost Girls . The study also highlights Moore?s lesser-known output, such as Halo Jones, Skizz , and Big Numbers , and his prose novel Voice of the Fire. Alan Moore: Comics as Performance, Fiction as Scalpel reveals Moore to be one of the most significant and distinctly postmodern comics creators of the last quarter-century.Intro -- Contents -- Preface and Acknowledgments -- Introduction -- CHAPTER 1. Formal Considerations on Alan Moore's Writing -- CHAPTER 2. Chronotopes: Outer Space, the Cityscape, and the Space of Comics -- CHAPTER 3. Moore and the Crisis of English Identity -- CHAPTER 4. Finding a Way into Lost Girls -- Conclusion -- Notes -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- ZEclectic British author Alan Moore (b. 1953) is one of the most acclaimed and controversial comics writers to emerge since the late 1970s. He has produced a large number of well-regarded comic books and graphic novels while also making occasional forays into music, poetry, performance, and prose. In Alan Moore: Comics as Performance, Fiction as Scalpel , Annalisa Di Liddo argues that Moore employs the comics form to dissect the literary canon, the tradition of comics, contemporary society, and our understanding of history. The book considers Moore's narrative strategies and pinpoints the main thematic threads in his works: the subversion of genre and pulp fiction, the interrogation of superhero tropes, the manipulation of space and time, the uses of magic and mythology, the instability of gender and ethnic identity, and the accumulation of imagery to create satire that comments on politics and art history. Examining Moore's use of comics to scrutinize contemporary culture, Di Liddo analyzes his best-known works-- Swamp Thing, V for Vendetta, Watchmen, From Hell, Promethea , and Lost Girls . The study also highlights Moore?s lesser-known output, such as Halo Jones, Skizz , and Big Numbers , and his prose novel Voice of the Fire. Alan Moore: Comics as Performance, Fiction as Scalpel reveals Moore to be one of the most significant and distinctly postmodern comics creators of the last quarter-century.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
In Alan Turing’s Name: Pardoning the Dead, Forgetting the Living
No full textThis special panel discussion brought together authorities on Alan Turing and the statutory pardon legislation intended to honour him. Leading academics, in conversation with those who have unsuccessfully petitioned to have offences disregarded, were joined by the Turing Bill’s author
Bernard Williams
No full textAn edited multi-author volume assessing the moral philosophy of the late British philosopher Bernard Williams. Contributors: Adrian Moore, John Skorupski, Alan Thomas, Robert B Louden, Michael Stocker, A. A. Long, Edward Crai
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