1,412,369 research outputs found
The Pick Knitwear Story: 1856-1956
No full textAn account of
]. PICK & SONS LTD LEICESTER
Manufacturers for a hundred years. 45 page company publication
The Pick Knitwear Story, Book Two: 1956-1991
No full textAn account of
]. PICK & SONS LTD LEICESTER
Manufacturers for a hundred years. 45 page company publication
Episode 87: Vegan Cinema with Anat Pick
No full textIn this episode of Knowing Animals I am joined by Anat Pick. Anat is Associate Professor of Film Studies at Queen Mary University of London. We discuss Anat’s book chapter ‘Vegan Cinema’ which will appear in the book 'Thinking Veganism in Literature and Culture: Towards a Vegan Theory', which was published by Palgrave Macmillan in 2018. That book is edited by Emilia Quinn and Ben Westwood
Film's Religious Algorithm
No full textThis article explores Simone Weil’s concept of ‘affliction’ and the black poetics of Saidiya Hartman and Fred Moten in relation to two nonfiction films: Artur Aristakisyan’s Palms (1993) and Forough Farrokhzad’s The House Is Black (1962). The films’ contentiousness springs from their provocative depictions of suffering, presented not as a social ill but as a defiant mode of being outside of institutional power. Supplanting the search for a cure with the search for salvation, the films transcend the socially-conscious logic of documentary in favour of a ‘religious algorithm’ of profound but recalcitrant weakness. As alternative ‘city symphonies’, Palms and The House Is Black’s municipal visions complement Hartman and Moten’s vivid accounts of insurgent black life in American cities
A Structural Econometric Model of Consumer Demand at Pick-Your-Own Fruit Operations
No full textThis paper develops a fully structural econometric consumer demand model for goods which have time and monetary costs, and where time spent obtaining the goods also enters into the utility function. The model is used to analyze customers' decision to buy pick-your-own versus pre-harvested fruit at North Carolina pick-your-own fruit operations. The empirical application distinguishes the double effect of time as a resource constraint and also providing utility. Elasticity estimates show that strawberries sold at pick-your-own operations are price elastic, with pick-your-own fruit being less price elastic than pre-harvested fruit.Consumer/Household Economics,
A behavioral view of Nevanlinna-Pick interpolation
No full textThe classical Nevanlinna-Pick (NP) interpolation problem is about finding a rational function that satisfies given interpolation conditions, along with a norm condition. In this paper we address the NP problem using concepts from behavioral systems theory and quadratic differential forms (QDFs). The NP problem is solved using a certain “dualization of data”. We address system theoretic motivations for this dualization and the advantages gained in this process. Finally, we address the problem of constructing interpolating functions that satisfy a “frequency dependent” norm condition
Performance Approximation and Design of Pick-and-Pass Order Picking Systems
No full textIn this paper, we discuss an approximation method based on G/G/m queuing network modeling using Whitt’s (1983) queuing network analyzer to analyze pick-and-pass order picking systems. The objective of this approximation method is to provide an instrument for obtaining rapid performance estimates (such as order lead time and station utilization) of the order picking system. The pick-and-pass system is decomposed into conveyor pieces and pick stations. Conveyor pieces have a constant processing time, whereas the service times at a pick station depend on the number of order lines in the order to be picked at the station, the storage policy at the station, and the working methods. Our approximation method appears to be sufficiently accurate for practical purposes. It can be used to rapidly evaluate the effects of the storage methods in pick stations, the number of order pickers at stations, the size of pick stations, the arrival process of customer orders, and the impact of batching and splitting orders on system performance.simulation;warehousing;order picking;queuing network;pick-and-pass
Order batching in multi-server pick-and-sort warehouses.
No full textIn many warehouses, customer orders are batched to profit from a reduction in the order picking effort. This reduction has to be offset against an increase in sorting effort. This paper studies the impact of the order batching policy on average customer order throughput time, in warehouses where the picking and sorting functions are executed separately by either a single operator or multiple parallel operators. We present a throughput time estimation model based on Whitt's queuing network approach, assuming that the number of order lines per customer order follows a discrete probability distribution and that the warehouse uses a random storage strategy. We show that the model is adequate in approximating the optimal pick batch size, minimizing average customer order throughput time. Next, we use the model to explore the different factors influencing optimal batch size, the optimal allocation of workers to picking and sorting, and the impact of different order picking strategies such as sort-while-pick (SWP) versus pick-and-sort (PAS)Order batching; Order picking and sorting; Queueing; Warehousing;
Intersecting Ecology and Film: A Paradigm Shift
No full textThis item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.This item is part 2 of the Screening Nature entry.Film theory and film studies have only recently rediscovered what is surely most visible about film: its entanglement in the world it shoots, edits, and projects. As a representational art, film ‘screens’ nonhuman nature as both revelation and concealment. The ambivalence of the screen and of the act of screening, whether as projecting and exhibiting or as filtering and veiling, comes to define film’s relationship to its materiality: its locations, onscreen lives, mise-en-scène, narrative structures, spectators, exhibition spaces, its carbon footprint and chemical building blocks, from celluloid to silicon. All of these are part of cinema’s diverse ecologies. Accordingly, the present study does not focus only on nature and animal films. We take as a point of departure films that foreground ecology in the wider sense of the word. The essays in this book are primarily interested in how something that figures as ‘nature’ becomes entangled and enmeshed in everything else. Many of the concerns Morton mentions are found here: ideology, race, class, gender, and sexuality, interspecies relations, questions of justice, politics, and aesthetics. We hope the collection offers a well-rounded demonstration of cinematic ecology in action. This introductory essay inscribes ecology and nature back into film studies, back to where nature always already is, in the hope of encouraging to ‘normalise,’ even institutionalise, a more ecocentric attention to cinema—attention to the interconnectedness of the natural world and humans within it as integral parts of the study and practice of film
Aspectes moleculars de dues malalties de transport lisosòmic: la cistinosi i la malaltia de Niemann-Pick tipus C
No full text[cat] La cistinosi i la malaltia de Niemann-Pick tipus C (NPC) són dues patologies hereditàries monogèniques poc freqüents, per aquest motiu estan classificades dins del grup de malalties anomenades rares. La cistinosi està causada per mutacions al gen CTNS, que codifica per una proteïna transmembrana del lisosoma que rep el nom de cistinosina. En canvi, la malaltia de NPC és deguda a mutacions al gen NPC1 o al gen NPC2, que codifiquen per una proteïna integral de la membrana lisosòmica i una proteïna soluble del lisosoma, respectivament, i aquestes reben el mateix nom que el gen, NPC1 i NPC2. El funcionament incorrecte d’aquestes proteïnes de transport dóna lloc a una acumulació de productes, diferent a ambdós casos, a l’interior del lisosoma, sent classificades com a malalties d’acumulació lisosòmica. Aquesta tesi doctoral s’ha centrat en l’anàlisi molecular de pacients afectes d’alguna d’aquestes dues malalties.
S’ha realitzat el primer estudi mutacional de cistinosi a la població espanyola, que ha permès la identificació de 15 mutacions diferents, 7 de les quals no havien estat descrites: tres mutacions de canvi de sentit (p.M1T, p.S270F i p.G309V), tres delecions (c.1-19_61del, c.295_310del i c.320_323delATCA) i una mutació de splicing (c.682-1G>T). La deleció de 57 kb és la mutació més freqüent a Espanya (38% dels al•lels) i conjuntament amb altres 5 mutacions representen el 73% dels al•lels estudiats. S’ha establert que els pacients amb fenotip clínic infantil tenen a ambdós al•lels mutacions que trunquen o que afecten aminoàcids conservats de les regions transmembrana de la proteïna. En canvi, la mutació p.S139F s’ha associat a la forma juvenil de la malaltia.
L’estudi mutacional realitzat a la malaltia de Niemann-Pick tipus C ha permès establir el genotip d’un gran nombre de pacients, identificant 74 mutacions diferents, 17 de les quals no havien estat descrites: set mutacions de canvi de sentit (p.P474A, p.G535V, p.F995L, p.F1079S, p.L1106P, p.G1209E i p.S1249G), dues mutacions sense sentit (p.Q775X i p.E1089X), dues insercions (p.L1117PfsX4 i p.I1061NfsX4), una deleció en pauta (p.N916del), quatre mutacions de splicing (c.58-3280C>G, c.882-28A>T, c.2604+5G>A i c.3591+5G>A) i la primera gran deleció que afecta al gen NPC1 i gens flanquejants. També s’han pogut establir correlacions genotip-fenotip per a un conjunt de mutacions.
També s’ha demostrat la implicació de diferents mecanismes cel•lulars en la malaltia de Niemann-Pick tipus C, segons els tipus de mutacions causants: el “splicing”, el procés de “nonsense-mediated mRNA decay” i la degradació proteica portada a terme pel proteasoma. S’han identificat mutacions intròniques profundes i s’ha caracteritzat el seu efecte en el mRNA, conjuntament amb el de les mutacions de “splicing” que afecten als llocs canònics. El mecanisme de NMD és el responsable de la degradació del mRNA en tots els al•lels analitzats que codifiquen per un PTC al gen NPC1. La majoria de mutacions de canvi de sentit analitzades condueixen a una reducció significativa o a l’absència de la proteïna NPC1, degut a què la proteïna NPC1 mutada és degradada per la via de la ubiquitina-proteasoma. La proteïna NPC1 mutada recuperada, després del tractament amb els inhibidors del proteasoma (ALLN i MG132), és capaç de disminuir els nivells de colesterol a totes les línies cel•lulars NPC estudiades. Aquesta observació podria obrir la porta a l’ús d’aquests fàrmacs com a futur tractament per a la malaltia de NPC causada per determinades mutacions de canvi de sentit.[eng] “Molecular aspects of both lysosomal transport diseases: cystinosis and Niemann-Pick disease type”. The cystinosis and Niemann-Pick disease type C (NPC) are two rare monogenic hereditary diseases. The cystinosis is caused by mutations in the gene CTNS, which encodes a transmembrane protein of the lysosome that is called cystinosin. NPC disease is caused by mutations in the NPC1 or NPC2 gene, encoding an integral lysosomal membrane protein and a soluble protein of the lysosome, respectively, and these are the same name as the gene, NPC1 and NPC2. The impaired transport leads to an accumulation of products, different in both cases, inside the lysosome, being classified as lysosomal storage disorders. This thesis has focused on the molecular analysis of patients with any of these diseases.
Molecular analysis in the Spanish cystinosis patients has allowed the identification of 15 different mutations, 7 of which had not been described. The 57-kb deletion is the most common mutation in Spain (38% of alleles) and together with other 5 mutations accounted for 73% of the studied alleles. The p.S139F mutation has been associated with the juvenile form of the disease.
Molecular analysis in NPC disease has established the mutation profile in a large number of patients. 74 different mutations have been identified, 17 of which had not been described previously, including the first large deletion affecting the whole NPC1 gene and flanking genes. Genotype-phenotype correlations have been established for several mutations.
Different cellular mechanisms are involving in NPC disease: splicing, nonsense-mediated mRNA decay and proteasomal degradation. Deep intronic mutations have been identified and the effect on the mRNA has been characterized. NMD process is responsible for the mRNA decay for all analyzed NPC1 PTC-encoding mutations. Several missense mutations lead to a significant reduction or absence of NPC1 protein, because the NPC1 mutant protein is degraded by the ubiquitin-proteasome pathway. Treatment with proteasome inhibitors partially reverses the NPC1 decrease and reduces cholesterol levels in all studied NPC cell lines. This observation might represent a therapeutical approach for future treatments of NPC disease caused by specific missense mutations
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