1,721,038 research outputs found
Serum thyroid hormone-binding proteins
No full textThyroid hormones circulate in the blood mostly and reversibly bound to a set of thyroid hormone binding proteins, the most important being thyroxine-binding globulin, transthyretin and albumin. These proteins may undergo genetic and inherited variations, either decrease or excess. These variations affect measurement of serum total thyroid hormones, but do not influence the levels of free (unbound to proteins) thyroid hormones, which represent the minute, but metabolically active fraction at the tissue level
Hypokalaemic periodic paralysis and hyperthyroidism. A case report
No full textThe hypokalaemic thyrotoxic periodic paralysis (HTPP) is a rare neuromuscular disorder in hyperthyroid Caucasian patients. We describe the case of a 31-yr-old man suffering from Graves' disease, admitted to Hospital with flaccid quadriplegia. In comparison with those previously reported, this case shows some peculiarities. Neuromuscular symptoms and signs appeared one year after the onset of hyperthyroidism. No HLA haplotype usually associated with HTPP was found. None of the various factors known to be able to trigger paralytic attacks was identified in our patient. We could not induce the typical neuromuscular picture by a provocative test with glucose and insulin administration. No hyperinsulinaemia was demonstrated either in basal condition or after oral glucose tolerance test. On the basis of these findings, the present case emphasizes the possible different pathogenesis of HTPP in Oriental and Caucasian patients
Vitamin D, sport and health: a still unresolved clinical issue
No full textVitamin D metabolites have a pleiotropic role in human physiology, both in static and dynamic conditions, and a lot of vitamin D-related biological effects could influence physical and sport performances in athletes. Probably due to different factors (e.g., drugs, doping, nutrition, ultraviolet B radiation exposure), in athletes a very high prevalence of vitamin D inadequacy (i.e., deficiency or insufficiency) has been observed. Vitamin D inadequacy in athletes could be associated with specific health risks and to alterations of functional capacities, potentially influencing the fine adjustment of physical performances during training and sport competitions. When risk factors for vitamin D inadequacy exist, a preventive vitamin D supplementation is indicated, and if a vitamin D inadequacy is diagnosed, its supplementation is recommended. Unfortunately, on these issues many concerns remain unresolved. Indeed, it is not clear if athletes should be classified as a special population at increased risk for vitamin D inadequacy; moreover, in comparison to the non-athletic population, it is still not clear if athletes should have different reference ranges and different optimal target levels for serum vitamin D, if they have additional health risks, and if they need different type of supplementations (doses) for prevention and/or replacement therapy. Moreover, in athletes also the abuse of vitamin D supplements for ergogenic purposes raise different ethical and safety concerns. In this review, the main physio-pathological, functional and clinical issues that relate vitamin D to the world of athletes are described
Can combination of glucocorticoids with other immunosoppressive drugs reduce the cumulative dose of glucocorticoids for moderate-to-severe and active Graves' orbitopathy?
No full textIs it caused by a true improvement of glycemic control or by an increased number of hypoglicemic events?
No full textTreatment of moderate-to-severe and active Graves’ orbitopathy: a step forward from the OPTIC study
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