196 research outputs found
Review of Space, geography, and politics in the early Roman Empire, by C. Nicolet
No full textPeer reviewed
Notes on Praetors in Spain in the Mid-Second Century B.C.
No full textThis article reassesses the ancient evidence on the praetors who fought in the Spains in the 150s and 140s, and argues against some recent reconstructions of the fasti praetorii for these years. In particular, two new possibilities are offered: L. Mummius, pr. in Hispania Ulterior 155 and prorogued through (at least) 154; and C. Laelius, pr. in a city jurisdiction in 145, and sent ex praetura to Citerior in 144, when his friend Scipio Aemilianus secured the removal of the Spains from the consular sortition for that year. If correct, this example of a city praetor setting out after the year of the magistracy for an overseas province would provide an early precedent for what was later to be a common practice, which Sulla as dictator finally was to institutionalize.Peer reviewe
Intramolecular rhodium carbenoid insertions into aromatic C-H bonds. Preparation of 1-carboalkoxy-1,3-dihydrobenzo[c]thiophene 2,2-dioxides
No full textPT: J; CR: ABRAMOVITCH RA, 1972, J CHEM SOC CHEM COMM, P893 CAVA MP, 1959, J AM CHEM SOC, V81, P4266 COREY EJ, 1965, TETRAHEDRON LETT, P793 COREY EJ, 1965, TETRAHEDRON LETT, P803 GAUTHIER JY, 1986, TETRAHEDRON LETT, V27, P15 JEFFORD CW, 1985, TETRAHEDRON LETT, V26, P6035 MILLS ML, 1964, J ORG CHEM, V29, P2329 NICOLAOU KC, 1980, J ORG CHEM, V45, P1463 OPPOLZER W, 1980, HELV CHIM ACTA, V63, P1703 OPPOLZER W, 1980, HETEROCYCLES, V14, P1615 PIRRUNG MC, 1986, 192ND ACS NAT M REGITZ M, 1972, SYNTHESIS-STUTTGART, P351 STORFLOR H, 1984, J CHEM SOC CHEM COMM, P208 TAYLOR EC, 1983, TETRAHEDRON LETT, V24, P5453 VANLEUSEN AM, 1970, Q REP SULFUR CHEM, V5, P67; NR: 15; TC: 18; J9: TETRAHEDRON LETT; PG: 4; GA: E9407Source type: Electronic(1
Ceftaroline: A cephalosporin with expanded Gram-positive activity
No full textInfections caused by resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are now posing a major health risk for patients in hospital and community settings. There is a need to evaluate new antibiotics that would offer reliable clinical efficacy combined with a favorable safety profile for the treatment of such infections. Ceftaroline is a new member of the cephalosporin class of antibiotics with expanded activity against Gram-positive pathogens such as MRSA, vancomycin-intermediate S. aureus, vancomycin-resistant S. aureus and multidrug-resistant Streptococcus pneumoniae, while retaining good activity against common Gram-negative organisms. Phase II and III studies have shown ceftaroline to be an effective and well-tolerated treatment-tor complicated skin and skin-structure infections compared with standard therapy. Trials are ongoing in the treatment of community-acquired pneumonia. © 2009 Future Medicine.Andes D, 2006, ANTIMICROB AGENTS CH, V50, P1376, DOI 10.1128-AAC.50.4.1376-1383.2006; [Anonymous], 2006, M100S16 CLSI; BARRY PM, 2008, 48 ANN INT C ANT AG; Bo G, 2000, CLIN MICROBIOL INFEC, V6, P6; COREY GR, 2008, 48 ANN INT C ANT AG; Fenoll A, 2008, ANTIMICROB AGENTS CH, V52, P4209, DOI 10.1128-AAC.00712-08; Ge Y, 2006, 46 ANN INT C ANT AG; Ge Y, 2008, ANTIMICROB AGENTS CH, V52, P3398, DOI 10.1128-AAC.00149-08; Hinshaw RR, 2008, 48 ANN INT C ANT AG; Iizawa Yuji, 2004, Journal of Infection and Chemotherapy, V10, P146; Ishikawa T, 2003, BIOORGAN MED CHEM, V11, P2427, DOI 10.1016-S0968-0896(03)00126-3; JACQUELINE C, 2008, 48 ANN INT C ANT AG; JACQUELINE C, 2006, 46 ANN INT C ANT AG; Jacqueline C, 2007, ANTIMICROB AGENTS CH, V51, P3397, DOI 10.1128-AAC.01242-06; Kanafani ZA, 2006, ENFERM INFEC MICR CL, V24, P182, DOI 10.1157-13086552; Mariani PG, 2006, J ANTIMICROB CHEMOTH, V58, P481, DOI 10.1093-jac-dkl256; MOISE PA, 2000, ANTIMICROB AGENTS S1, V16, pS31; Mushtaq S, 2007, J ANTIMICROB CHEMOTH, V60, P300, DOI 10.1093-jac-dkm150; Riccobene T, 2008, 48 ANN INT C ANT AG; Sader HS, 2008, ANTIMICROB AGENTS CH, V52, P1153, DOI 10.1128-AAC.01351-07; Sader HS, 2005, ANTIMICROB AGENTS CH, V49, P3501, DOI 10.1128-AAC.49.8.3501-3512.2005; Sakoulas G, 2004, J CLIN MICROBIOL, V42, P2398, DOI 10.1128-JCM.42.6.2398-2402.2004; SARAVOLATZ LD, 2008, 48 ANN INT C ANT AG; SCHAADT RD, 2007, 47 ANN INT C ANT AG; Silverman JA, 2005, J INFECT DIS, V191, P2149, DOI 10.1086-430352; Talbot GH, 2007, ANTIMICROB AGENTS CH, V51, P3612, DOI 10.1128-AAC.00590-07; Tenover FC, 2007, CLIN INFECT DIS, V44, P1208, DOI 10.1086-513203; VIDAILLAC C, 2008, 48 ANN INT C ANT AG; Villegas-Estrada A, 2008, J AM CHEM SOC, V130, P9212, DOI 10.1021-ja8029448; Woods CW, 2004, CLIN INFECT DIS, V38, P1188, DOI 10.1086-383027; XIONG YQ, 2007, 47 ANN INT C ANT AG24181
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The Last Window
No full textPoems written by a student in the UNT Honors College that includes a preface discussing the long poem style employed by the author and others
Tedizolid (TR-701): A new oxazolidinone with enhanced potency
No full textIntroduction: Tedizolid phosphate (TR-701) is a new oxazolidinone prodrug that is transformed in the serum into the active drug tedizolid (TR-700). Tedizolid acts by inhibiting protein synthesis and has broad activity against Gram-positive pathogens, including strains that are resistant to linezolid. Areas covered: This review summarizes the currently available data on this new antimicrobial agent. In vitro activity, pharmacokinetics-pharmacodynamics, clinical efficacy and safety are all addressed. Expert opinion: Tedizolid will provide a useful addition to the antimicrobial armamentarium, particularly in complicated skin and skin structure infections, due to its high oral bioavailability and once-daily dosing. The results of future studies will serve to better position tedizolid among the newly approved agents for infections caused by Gram-positive organisms. © 2012 Informa UK, Ltd.[Anonymous], 2001, AM J INFECT CONTROL, V29, P404; Betriu C, 2010, ANTIMICROB AGENTS CH, V54, P2212, DOI 10.1128-AAC.01653-09; Bien P., 2010, 50 INT C ANT AG CHEM; Brown SD, 2010, ANTIMICROB AGENTS CH, V54, P2063, DOI 10.1128-AAC.01569-09; Chang S, 2003, NEW ENGL J MED, V348, P1342, DOI 10.1056-NEJMoa025025; Colak D, 2002, J ANTIMICROB CHEMOTH, V50, P397, DOI 10.1093-jac-dkf134; Colca JR, 2003, J BIOL CHEM, V278, P21972, DOI 10.1074-jbc.M302109200; Dreskin H, 2011, 51 INT C ANT AG CHEM; Falagas ME, 2006, J ANTIMICROB CHEMOTH, V58, P273, DOI 10.1093-jac-dkl219; Fluit AC, 2001, J CLIN MICROBIOL, V39, P3727, DOI 10.1128-JCM.39.10.3727-3732.2001; Fridkin SK, 2005, NEW ENGL J MED, V352, P1436, DOI 10.1056-NEJMoa043252; Gould IM, 2008, INT J ANTIMICROB AG, V31, P1, DOI 10.1016-S0924-8579(08)70002-5; Hiramatsu K, 1997, J ANTIMICROB CHEMOTH, V40, P135, DOI 10.1093-jac-40.1.135; Housman ST, 2011, 51 INT C ANT AG CHEM; Hsueh PR, 1999, INFECT CONT HOSP EP, V20, P828, DOI 10.1086-501592; Im WB, 2011, EUR J MED CHEM, V46, P1027, DOI 10.1016-j.ejmech.2011.01.014; Jacobson LM, 2009, PEDIATR INFECT DIS J, V28, P445, DOI 10.1097-INF.0b013e3181927891; Jones RN, 2009, J ANTIMICROB CHEMOTH, V63, P716, DOI 10.1093-jac-dkp021; Keel RA, 2011, 51 INT C ANT AG CHEM; Kirst HA, 1998, ANTIMICROB AGENTS CH, V42, P1303; Leach KL, 2007, MOL CELL, V26, P393, DOI 10.1016-j.molcel.2007.04.005; LECLERCQ R, 1988, NEW ENGL J MED, V319, P157, DOI 10.1056-NEJM198807213190307; Lemaire S, 2009, J ANTIMICROB CHEMOTH, V64, P1035, DOI 10.1093-jac-dkp267; Livermore DM, 2009, J ANTIMICROB CHEMOTH, V63, P713, DOI 10.1093-jac-dkp002; Locke JB, 2009, ANTIMICROB AGENTS CH, V53, P5265, DOI 10.1128-AAC.00871-09; Louie A, 2011, ANTIMICROB AGENTS CH, V55, P3453, DOI 10.1128-AAC.01565-10; Mangili A, 2005, CLIN INFECT DIS, V40, P1058, DOI 10.1086-428616; Moellering RC, 2003, ANN INTERN MED, V138, P135; Moise PA, 2000, INT J ANTIMICROB AG, V16, pS31; Munoz KA, 2011, 21 EUR C CLIN MICR I; Prasad JV, 2007, CURR OPIN MICROBIOL, V10, P454, DOI 10.1016-j.mib.2007.08.001; Prokocimer P, 2008, 48 INT C ANT AG CHEM; Prokocimer P, 2011, ANTIMICROB AGENTS CH, V55, P583, DOI 10.1128-AAC.00076-10; Ramsey AM, 2009, INFECT CONT HOSP EP, V30, P184, DOI 10.1086-593956; Rodriguez-Avial I, 2012, J ANTIMICROB CHEMOTH, V67, P167, DOI 10.1093-jac-dkr403; Sakoulas G, 2004, J CLIN MICROBIOL, V42, P2398, DOI 10.1128-JCM.42.6.2398-2402.2004; Garcia MS, 2010, JAMA-J AM MED ASSOC, V303, P2260, DOI 10.1001-jama.2010.757; Schaadt R, 2009, ANTIMICROB AGENTS CH, V53, P3236, DOI 10.1128-AAC.00228-09; Shaw KJ, 2008, ANTIMICROB AGENTS CH, V52, P4442, DOI 10.1128-AAC.00859-08; SMALL PM, 1990, ANTIMICROB AGENTS CH, V34, P1227; UTTLEY AHC, 1989, EPIDEMIOL INFECT, V103, P173; van Hal SJ, 2011, EUR J CLIN MICROBIOL, V30, P603, DOI 10.1007-s10096-010-1128-3; VOSS A, 1994, EUR J CLIN MICROBIOL, V13, P50, DOI 10.1007-BF02026127; Woods CW, 2004, CLIN INFECT DIS, V38, P1188, DOI 10.1086-383027; Yamaki J, 2011, ANTIMICROB AGENTS CH, V55, P4432, DOI 10.1128-AAC.00122-11; Yum JH, 2010, ANTIMICROB AGENTS CH, V54, P5381, DOI 10.1128-AAC.00728-10; Zetola N, 2005, LANCET INFECT DIS, V5, P275, DOI 10.1016-S1473-3099(05)70112-214171
From Mendel to me: Constructing genetics knowledge through historical problem-based learning
No full textJournal Articl
The Kongo cosmogram: A theory in African-American literature, 1997
No full textThis study examines the use of Kongo cosmology as a theory of reading African-American literature. By analyzing the philosophical modes and belief systems of the Bakongo people, a general view of their cosmos is constructed and establishes the Kongo cosmogram used as the basis of this study. The community, crossroads, elders, and circularity of life all prove to be crucial elements in the Kongo cosmogram. These elements all have respective roles in the operation of the Kongo cosmogram as a literary theory. As the focus shifts from Africa to America, a study of how the Kongo cosmogram is disrupted by the Maafa and reconstructed in America via plantation existence is necessary to establish the history and function of the cosmogram in America. Finally, the Kongo cosmogram is applied as a literary theory, using Lorraine Hansberry's "A Raisin in the Sun" and James Baldwin's Go Tell It on the Mountain. These texts manifest the elements of the Kongo cosmogram and demonstrate its applicability as a literary theory
Geographic profiling in Nazi Berlin: fact and fiction
No full textGeographic profiling uses the locations of connected crime sites to make inferences about the probable location of the offender’s ‘anchor point’ (usually a home, but sometimes a workplace). We show how the basic ideas of the method were used in a Gestapo investigation that formed the basis of a classic German novel about domestic resistance to the Nazis during the Second World War. We use modern techniques to re-analyse this case, and show that these successfully locate the Berlin home address of Otto and Elise Hampel, who had distributed hundreds of anti-Nazi postcards, after analysing just 34 of the 214 incidents that took place before their arrest. Our study provides the first empirical evidence to support the suggestion that analysis of minor terrorism-related acts such as graffiti and theft could be used to help locate terrorist bases before more serious incidents occur
Durability of environment-recruitment relationships in aquatic ecosystems: insights from long-term monitoring in a highly modified estuary and implications for management
No full textAbstractThe environment can strongly influence the survival of aquatic organisms and their resulting dynamics. Our understanding of these relationships, typically based on correlations, underpins many contemporary resource management decisions and conservation actions. However, such relationships can break down over time as ecosystems evolve. Even when durable, they may not be very useful for management if they exhibit high variability, context dependency, or non-stationarity. Here, we systematically review the literature to identify trends across environment-recruitment relationships for aquatic taxa from California’s San Francisco Bay and Sacramento-San Joaquin Delta Estuary. This is one of the most heavily modified aquatic ecosystems in North America, and home to numerous species of concern whose relationships with the environment inform regulatory actions and constraints. We retested 23 of these relationships spanning 9 species using data that have accumulated in the years since they were first published (9-40 additional years) to determine whether they persisted. Most relationships were robust (i.e., same or stronger in magnitude) to the addition of new data, but the ability to predict how a species will respond to environmental change did not generally improve with more data. Instead, prediction error generally increased over time and in some cases very quickly, suggesting a rapid regime shift. Our results suggest that more data alone will not necessarily improve the ability of these relationships to inform decision making. We conclude by synthesizing emerging insights from the literature on best practices for the analysis, use, and refinement of environment-recruitment relationships to inform decision making in dynamic ecosystems.</jats:p
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