1,093 research outputs found
Evidence based recommendations for national healthcare-associated infection surveillance
No full textThis thesis has provided new knowledge about the surveillance of healthcare associated infections both in Australia and internationally. Using a mixed methods approach, a series of evidence based and pragmatic recommendations for a national surveillance program in Australia have been generated. Gaps in current surveillance activities across Australia were identified, and findings from the novel application of a discrete choice experiment, have identified strong key stakeholder support for a preferred national program to reduce the burden of infections in Australian hospitals
Papel del factor de transcripción Kruppel-like factor 2 en la disfunción endotelial hepática asociada a la hipertensión portal y al daño por isquemia y reperfusión
No full textEl endotelio disfuncional presenta, entre otras caracteristicas, alteración en los mecanismos de vasodilatación, complicaciones trombóticas, disminución de la resistencia al estrés oxidativo, aumento de la expresión de moléculas de adhesión y de la secreción de moléculas proinflamatorias. El factor de transcripción endotelial KLF2 juega un importante papel en la regulación del fenotipo protector endotelial y su expresión depende de las fuerza hemodinámicas generadas por el flujo sanguíneo y de la administración exógena de estatinas.
La hipertensión portal y el daño hepático por I/R son dos condiciones patológicas asociadas a disfunción endotelial. Los trastornos estructurales característicos de la cirrosis hepática, la mayor causa prevalente de hipertensión portal en nuestro entorno, se acompañan de variaciones en las fuerzas hemodinámicas que pueden modificar la expresión de KLF2 y su programa transcripcional vasoprotector. Asímismo, durante la isquemia asociada a la preservación de injertos hepáticos para transplante, la interrupción de las fuerzas hemodinámicas generadas por el flujo sanguíneo podría resultar en la reducción de los programas endoteliales vasoprotectores, que se debería en parte a la pérdida de expresión de KLF2.
Los trabajos de investigación de la presente tesis doctoral amplian el conocimiento de los mecanismos moleculares responsables de la disfunción endotelial hepática, demostrando:
1. Que KLF2 está muy expresado en los hígados cirróticos y que su expresión se induce en las fases tempranas de la progresión de la enfermedad, representando un mecanismo compensador para mejorar los desórdenes vasculares característicos de los hígados cirróticos.
2. Que los hígados preservados en condiciones de transplante muestran un descenso tiempo-dependiente de KLF2, acompañado de daño hepático y aumentada resistencia vascular.
Además, demostran que la modulación farmacologica de la expresión de KLF2 puede ser beneficiosa tanto en el tratamiento de la hipertensión portal como en la preservación de los injertos hepáticos para transplante
Per un inedito capitolo burlesco attribuito al Marino
No full textIl saggio pubblica, sulla base di un manoscritto della Biblioteca Nazionale di Roma, un inedito testo burlesco del Marino, da assegnare ai suoi anni napoletani ma mai reso pubblico nel corso della vita dell'autore.The essay shall, on the basis of a manuscript in the Biblioteca Nazionale in Rome, an unpublished text burlesque of Marino, to assign to his Neapolitan years but never made public during the life of the author
Corrigendum to ‘Eribulin in combination with bevacizumab as second-line treatment for HER2-negative metastatic breast cancer progressing after first-line therapy with paclitaxel and bevacizumab: a multicenter, phase II, single arm trial (GIM11-BERGI)’: (ESMO Open (2021) 6(2), (S2059702921000089), (10.1016/j.esmoop.2021.100054))
No full textThe authors regret that at the time the article was published the following two authors were missing from the author list: R. Caputo and D. Cianniello. Both authors affiliation is the Breast Oncology Department, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy. The updated author list is as follows: C. De Angelis, D. Bruzzese, A. Bernardo, E. Baldini, L. Leo, A. Fabi, T. Gamucci, P. De Placido, F. Poggio, S. Russo, V. Forestieri, R. Lauria, I. De Santo, R. Caputo, D. Cianniello, A. Michelotti, L. Del Mastro, M. De Laurentiis, M. Giuliano, S. De Placido, G. Arpino. The authors would like to apologise for any inconvenience caused
Neoestetica: un archetipo disciplinare
No full textThe paper focuses on Du Bos’ contribution to the birth of aesthetics. Du Bos elaborates – in an anticlassicistical tone – three central notions: 1) that of “artificial passion”, 2) of the taste of “the public” (which is in turn linked to a peculiar conception of “feeling”) and 3) of “artistic genius”. The main tenet will be that such an approach does lead to a “philosophy of fine arts” (or of “artistic beauty”), i.e. the discipline with which modern aesthetics ends up identifying at the end of the xviii century. Hence the theoretical, and not just historical, interest for this author, especially when having an eye to neoaesthetics, viz. aesthetics as begotten by the crisis of the modern aesthetics around the middle of the xix century
The role of molecular techniques in preventing oral cancer and improving its poor prognosis: an illusion?
No full textauthor reply 249-51
The role of molecular techniques in preventing oral cancer and improving its poor prognosis: an illusion?
No full textauthor reply 249-51
Finding from the 2018 survey
No full text[Report] -- Executive Summary -- Resources List.prepared by: Grace L. Chikoto-Schultz, Andrew Russo, & Paul Manson (Portland State University) with Jim White (Nonprofit Association of Oregon).Title from PDF cover (viewed on October 29, 2020)."This report summarizes results from a survey administered in spring 2018 to 501(c)(3) charitable benefit nonprofit organizations across Oregon ... the survey results are quite telling of how concerned and informed nonprofit respondents are about potential hazards, what actions they have taken to prepare for potential disasters, as well as their perceived roles should a major disaster like the Cascadia Subduction Zone (CSZ) event occur"--Page 4.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
A Decade of Trials of Interferon-Alpha for Chronic Hepatitis C. A Meta-Regression Analysis
No full textThe most relevant randomized controlled trials of interferon-alpha (IFN) for naive patients with chronic hepatitis C (CHC) published in a decade, just before appearance of pegylated IFN trials in 2000, were included in this paper. Its purpose is to review the relationship between sustained biochemical response in active versus control group versus usual clinical variables as IFN regimens, cirrhosis, genotype and versus less frequently addressed variables as funding, methodological quality or location of principal author. Meta-analysis estimates of global treatment effect varied according to trial design: group 1=IFN versus placebo/no treatment, 32 RCTs, 2499 pts, OR 9.5 (6.3-14.2); group 2a=comparison of IFN schedules, 43 RCTs, 7454 pts, OR 1.6 (1.4-1.9); group 2b=IFN+other drugs versus standard IFN, 30 RCTs, 4737 pts, OR 2.0 (1.6-2.6). Fixed effects (arm-level) meta-regression on the complete data set (171 arms, 10,580 pts) revealed that sustained response was most likely in experimental arms of IFN+ribavirin or other drugs (OR 2.4), arms using yearly schedule (OR 2.0), trial principal author from Asia (OR 1.7), trial sample size >200 (OR 1.4) and arms enrolling less than 50% of cirrhotics (OR 1.3). Moreover, focus was on some significant interactions too, as the effect of trial''s quality interacting to the recorded funding (more benefit if no-profit, less if for-profit) and the effect of trial funding interacting to the location of first author (more benefit if from Asia). Three main effects (experimental arm, cirrhosis, funding) and one interaction (funding*location of principal author) explained 31% of between study variability in a random-effect meta-regression. In a subgroup analysis on a data set including available information on HCV genotype (93 arms, around 7000 pts), meta-regression revealed that genotype 1 or 4 less than 50% per arm and specialistic journal were significant predictors of either biochemical (transaminases) or virological (HCV-RNA) sustained response, in a model including the same main effects identified in the complete data set analysis. Finally, although mostly captured by different IFN regimens along time, heterogeneity of effect in a large set of (not-pegylated) IFN trials was also explained by HCV genotype and variables of quality and reporting, such as trial''s principal author from Asia
The Narratological Notion of “Career Implied Author”: its Roots, Development, and Use
No full textIl panorama narratologico attuale appare dominato da teorie anglocentriche. La scarsa comunicazione tra questi studiosi e quelli di area slava sembra condurre a una situazione paradossale: teorici inglesi e americani introducono concetti ai loro occhi “nuovi”, ma in realtà già ampiamente indagati, ad esempio, dal Formalismo russo. Sulla base di queste premesse, il contributo presenta un’attenta analisi storica e comparativa attorno alla nozione di “career implied author”, cercando infine di stimolare un dialogo costruttivo, presupposto necessario per un solido sviluppo della disciplina
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