1,746 research outputs found
Tradução de uma disputa : Christophe versus Pétion em La tragédie du roi Christophe, de Aimé Césaire
No full textEsta contribuição propõe a tradução comentada da primeira cena da peça de teatro La Tragédie du roi Christophe (A tragédia do rei Christophe), de Aimé Césaire. O texto foi publicado pelo autor martinicano em 1963 e encenado a partir de 1964. A história aborda o embate histórico entre os dois líderes revolucionários haitianos, Alexandre Pétion (1770-1818) e Henry Christophe (1767-1820), após o estabelecimento da independência do Haiti, em 1804. O ex-escravizado Henry Christophe I, autoproclamado rei do Haiti em 1811, protagoniza, na peça, os impasses políticos decorrentes do processo de descolonização para a constituição de um novo estado haitiano livre e democrático. Optamos por traduzir a cena que anuncia e ilustra, na abertura do primeiro Ato, o caráter trágico que permeia o desenrolar dos eventos.This contribution proposes the commented translation of the first scene of the play La Tragédie du roi Christophe (The tragedy of King Christophe), by Aimé Césaire. The text was published by the Martinican author in 1963 and staged from 1964 onwards. The story addresses the historical clash between the two Haitian revolutionary leaders, Alexandre Pétion (1770-1818) and Henry Christophe (1767-1820), after the establishment of Haitian independence in 1804. The ex-enslaved Henry Christophe I, self-proclaimed King of Haiti in 1811, stars, in the play, political impasses resulting from the decolonization process, for the constitution of a new free and democratic Haitian state. We chose to translate the scene that announces and illustrates, in the opening of the first Act, the tragic character that permeates the unfolding of events
Development of new therapeutic approaches in the fight against arenavirus infections : vaccination and passive immunotherapy
No full textLa famille des Arenaviridae comporte sept virus responsables de fièvres hémorragiques humaines. Ces virus représentent un risque naturel pour les populations vivant dans les zones endémiques, ou y séjournant comme les militaires français déployés. Ce risque peut également toucher des populations vivant en dehors des zones endémiques en raison du risque d'importation d'un patient infecté ou consécutivement à l'utilisation intentionnelle et malveillante de tels virus dans le cadre d'une attaque bioterroriste. Les fièvres hémorragiques humaines causées par les arénavirus sont relativement rares et les premiers symptômes, non spécifiques, sont souvent confondus avec ceux de maladies plus fréquentes dans ces régions, comme le paludisme ou les arboviroses. Par conséquent, le diagnostic clinique est souvent retardé, ce qui réduit l'efficacité du seul traitement étiologique actuellement préconisé, la ribavirine. Dans ce contexte, le développement de solutions prophylactiques similaires au vaccin Candid #1, protégeant contre l'arénavirus Junin, constituent une alternative intéressante. Dans le cadre du développement de candidats vaccins, la première stratégie utilisée dans ce travail a consisté à atténuer la pathogénicité du virus d'intérêt en ciblant une étape clé de la réplication des arénavirus. Nous avons choisi l'étape du bourgeonnement viral, dont l'acteur principal est la protéine Z. Une preuve de concept a été réalisée avec le virus de la chorioméningite lymphocytaire (LCMV). Pour cela, nous avons conçu un système de génétique inverse qui exprime un segment L viral où le gène de la protéine Z est remplacé par un gène d'intérêt. De manière surprenante, ce virus recombinant était capable de produire en culture cellulaire une progénie à un titre très faible sans l'apport en trans de la protéine Z. Nous avons identifié des domaines tardifs dans la séquence peptidique de la nucléoprotéine, motifs peptidiques permettant le détournement de la machinerie cellulaire impliquée dans la production d'exosomes et présents dans les protéines de matrices virales, comme la protéine Z des arénavirus. Nous avons observé que ces domaines pourraient partiellement compenser l'absence de la protéine Z. Des résultats similaires ont été obtenus avec deux autres arénavirus ayant une importance majeure en santé publique, les virus Lassa et Machupo, tous deux responsables de fièvres hémorragiques humaines. Cette suppression pourrait constituer une stratégie d'atténuation et semblerait prometteuse en vue du développement de candidats vaccins réplicatifs atténués. En effet, elle pourrait être utilisée sur plusieurs arénavirus responsables de pathologies humaines. Une approche complémentaire à cette stratégie vaccinale a été envisagée. Dans le but de développer un traitement d'urgence, utilisant des immunoglobulines équines hautement purifiées, les F(ab')2, selon la méthodologie de la société Fab'entech, deux études préliminaires ont été réalisées. La première a permis de vérifier la capcité des virus à se répliquer dans les cellules immunitaires circulantes de cheval. La seconde a permis l'évaluation du cahier des charges qualité de particules virales en vue de leur utilisation comme source d'antigène afin de produire les F(ab')2. Une seconde stratégie vaccinale a été envisagée, basée sur une modification du nombre de segments génomiques viraux. Des travaux précédents ont montré qu'un arénavirus à 3 segments, au lieu de 2, était viable et atténué, tout en pouvant exprimer 2 gènes d'intérêt supplémentaires. Cette stratégie a été utilisée sur le virus Machupo, responsable de fièvres hémorragiques en Bolivie. Ce virus recombinant devrait exprimer les glycoprotéiques tronquées des virus Chapare et Guanarito. Ce candidat vaccin a été caractérisé en culture cellulaire, et a induit une protection de 50% des animaux lors d'une administration en post-exposition [etc...]The Arenaviridae family comprises seven viruses responsible for human hemorrhagic fevers. These viruses represent a natural threat to the local populations, healthcare workers and scientists, as well as to the French forces deployed in the regions where these viruses are endemic. This viral threat can also be intentional in case of a bioterrorist attack. Human hemorrhagic fevers caused by arenaviruses are relatively rare and the first symptoms, frequently non-specific, are often confused with more common diseases such as malaria. Therefore, their diagnosis is delayed, which reduces the efficacy of ribavirin, the only etiological treatment currently recommended. ln this context, the development of prophylactic treatments, such as the Candid #1 vaccine targeting the Junin arenavirus, are an interesting alternative. The first strategy developed in this work to produce a vaccine candidate relied on the attenuation of the virus of interest by targeting a key stage of its replication. We chose the egress step, in which the main actor is the Z protein. This work was conducted using the lymphocytic choriomeningitis virus (LCMV). We therefore designed a reverse genetic system, and replaced the Z gene by the fluorescent protein eGFP reporter gene. Surprisingly, during its cellular infection, a progeny was detected in absence of the Z protein trans-complementation although the titer remained very low. ln this infectious model, we further identified late motifs in the nucleoprotein genome, comparable to those known in the Z protein. These NP late motifs seemed to play an essential role in the compensation of the absence of the Z protein. Similar results were observed using two others arenaviruses of medical importance, the Lassa and Machupo viruses, responsible of human hemorrhagic fevers. The strong diminution of the resulting vaccine candidate replication suggests that this strategy would render safe enough BSL-4 viruses to be used as a multivalent vaccine platform in humans. A complementary approach has been studied in this work. ln order to develop an emergency treatment, based on the production of highly purified F(ab')2 equine immunoglobulins, according to the Fab'entech technology. Two preliminary studies were carried out. The first one consisted in the study of the replication of arenaviruses in circulating horse's white blood cells. The second tested the specifications of attenuated viral particles that could be used as an antigen source to produce the F(ab')2 under good manufacturing practices. Another vaccine strategy was developed using the previously described duplication of the LCMV S genomic small segment in order to produce a tri-segmented recombinant virus. This genetic modification, known to attenuate the LCMV virus pathogenicity, allows the expression of two genes of interest. This strategy has been applied onto the South American Machupo virus, responsible for hemorrhagic fevers in Bolivia. A recombinant Machupo virus was designed to express the truncated glycoproteins of the Chapare and Guanarito viruses, two other New World mammarenaviruses responsible of human hemorrhagic fevers. This vaccine candidate was characterized in cell culture, and showed a 50% post-exposure protective effect in the animal model used. Taken together this work led to the development of two vaccine strategies and to the identification of a promising source of antigens to be used to produce highly purified F(ab')2 polyclonal immunoglobulin, which is the first step to the development of an emergency treatmen
Morisset/PyNeb_devel: 1.1.9
No full textcommit ab6cdb8a4af2ff75b82fc1422004934945c82530
Author: morisset [email protected]
Date: Sat Jul 6 11:25:45 2019 -0700
1.1.9
V 1.1.9
commit f7e6a418d2affb8db163c8c6c2428173b5f4aacf
Author: morisset [email protected]
Date: Fri Jun 7 07:15:42 2019 -0700
Create _chianti_tools_9.py
commit 81213b885e2b359a62e3d6e73515e39dc7056561
Author: Christophe Morisset [email protected]
Date: Wed Jun 5 16:19:33 2019 -0700
Adding Chianti 9
commit 5a9a7dfc9a4d922a216ac11f39b76c2d63097d3b
Author: Christophe Morisset [email protected]
Date: Wed Jun 5 16:19:05 2019 -0700
1.1.9b4
commit 152f9192847cd7f3194e0a778caca66f966392c1
Author: morisset [email protected]
Date: Wed May 22 14:13:30 2019 -0700
T_min ans max were not used
commit 22aeec4db4efc7bcc377b54a92292e157335825d
Author: morisset [email protected]
Date: Sun May 19 10:18:52 2019 -0700
1.1.9b3
commit 4dc721eecdd2511fcde69f835fc6181f7be1b74d
Author: morisset [email protected]
Date: Sun May 19 10:18:34 2019 -0700
manage wl<Lyalpha master
commit 44192233b57ef46cc479e6bfc2a9020cbfc3d5f6
Author: morisset [email protected]
Date: Fri May 17 13:07:55 2019 -0700
1.1.9b2
commit 95e07d78fb38cc6267f38e11d3051738814a4dfd
Author: morisset [email protected]
Date: Fri May 17 13:07:47 2019 -0700
light wl array
commit 9a159290e931fbdbbff8b13968d7540f8b0cef18
Author: morisset [email protected]
Date: Fri May 17 13:07:27 2019 -0700
add continuum to init
commit da0e0b6ac19bc6808bc7366217ad4a0885e1ca0e
Author: morisset [email protected]
Date: Thu Mar 21 11:48:08 2019 -0300
1.1.9b1
before branch to Regresor developemen
Christophe Colomb, le caoutchouc et les tétines
No full textChristoph Kolumbus, Kautschuk und die Gummisauger.
Der Verfasser schildert kurz die Geschichte des Kautschuks und erwänt die apotheker welche daran beteiligt sind. Er legt anschliessend die Geschichte der Gummisauger und der Milchflaschen dar, deren eine der meistgängisten die « Robert'sche Milchflasche » gewesen ist.Christopher Columbus, rubber, and rubber nipples.
The author quickly traces the history of rubber, making note of the pharmacists who therein played a role. He exhibits the history of rubber nipples and that of infant bottles, of which one of the most widely used was the « Robert Bottle. »Labeÿ Robert. Christophe Colomb, le caoutchouc et les tétines. In: Revue d'histoire de la pharmacie, 82ᵉ année, n°300, 1994. pp. 55-63
Christophe Defeuilley, L’Entrepreneur et le Prince. La création du service public de l’eau
No full textBehind Christophe Defeuilley’s poetic title lies a comparative historical analysis of the establishment of public drinking water services in London, New York, and Paris, the three most populous cities at the dawn of the 20th century. The author combines the lens of economics and a long-term perspective (from the 16th to the beginning of the 20th century) focused largely on private and public actors, to trace how water distribution systems evolved and crystalized into the form they still have ..
Novel Dialogue 5.3 It’s on The Illabus: A Discussion with Jean-Christophe Cloutier and John Jennings (SW)
No full textJohn Jennings—Hugo Award winner, New York Times bestselling author, curator, scholar, and Artist—is keenly aware that in adapting novels for the graphic format, his decisions turn what has only been imagined into facts drawn on the page. In this conversation with critic, translator, and teacher of a creative course on the art of making comics, Jean-Christophe Cloutier, Jennings explores how he makes those decisions that range from the design of endpapers to selecting a character’s skin tone with the ultimate aim of championing Black culture and Black comics. Given that Jennings has just entered the Marvel Universe with the debut of Silver Surfer: Ghost Light, the timing is right to reflect on the pressures and pleasures of adapting beloved stories for a contemporary audience. Jennings is both teacher and student of comics’ powerful lessons, and lucky for listeners, his course comes with an illustrated syllabus, aka illabus. In the podcast’s first ever episode about graphic novels, Jennings and Cloutier talk comic book history, the power of collaboration, and the importance of long showers
Aficionados et opposants à la tauromachie. Les formes plurielles de la civilisation
No full textAficionados and Opponents to the Tauromachy. The Plural Forms of Civilization
Christophe Traïni
The opposition to the Spanish tauromachy constitutes an emblematic case of involvement aiming to build up the animal cause. Starting from Norbert Elias theory concerning the civilisation processes, the author attempts to point out the emotional economies which underlie both aficionados' passion and the denunciations of the opponents to the corrida. The author refers here to the comparative vocation of Elias theory to make intelligible the incomprehension which may resuit from the different ways of investing the civilisation values. This perspective aliows explicating why and how the bull takes on different virtues and statutes.Aficionados et opposants à la tauromachie. Les formes plurielles de la civilisation
Christophe Traïni
L'opposition à la tauromachie espagnole constitue incontestablement un cas emblématique des engagements visant à édifier la cause animale. A partir de la théorie de Norbert Elias relative aux processus de civilisation, l'auteur s'efforce de mettre en exergue les économies émotionnelles qui sous-tendent aussi bien la passion des aficionados que les dénonciations virulentes des opposants à la corrida. La vocation comparative que le sociologue allemand a toujours attribuée à sa théorie est rappelée ici avec force afin de rendre intelligible les incompréhensions qui peuvent résulter de différentes modalités d'investissement des valeurs de la civilisation. Cette perspective permet, plus particulièrement, d'expliciter pourquoi et comment le taureau se voit attribué des vertus et un statut des plus divergents.Traïni Christophe. Aficionados et opposants à la tauromachie. Les formes plurielles de la civilisation. In: Politix, vol. 16, n°64, Quatrième trimestre 2003. La question animale, sous la direction de Nicolas Dodier, Pierre-Benoît Joly et Cyril Lemieux. pp. 103-125
Taxation of financial assets in developing countries
No full textIn developing countries, most financial assets in formal markets are deposits at financial institutions. This potentially important tax base could be taxed at a low administrative cost. When revenues of financial taxes are significant, implicit taxes dwarf explicit taxes. The author focuses on the implicit taxation of financial assets through seigniorage, reserve requirements, lending targets, and interest ceilings combined with inflation. The last instrument has often been overlooked, but it has generated more than a third of implicit revenues in some cases by lowering the cost of government borrowing. Tax revenues are difficult to measure because of regulations that prevent the use of market prices for computation and distort the meaning of some definitions. For some countries, the standard method of seigniorage grossly underestimates the revenue from financial taxation. The author discusses various sources of distortion but ignores potential impacts on the level of saving and the growth rate. Although taxes on financial assets have a low administrative cost, the excess burden that stems from the misallocation of resources is probably a much higher fraction of revenues than that of other taxes.Economic Theory&Research,Environmental Economics&Policies,Banks&Banking Reform,Public Sector Economics&Finance,Municipal Financial Management
Giving shape to time: An investigation into mixed-media installation
No full textThis research investigates ways of shaping time and identifying the characteristics of time that evolve in my art practice with reference to a synthesis of two and three-dimensional material, sound, and video. The nature of this study is a three-way material exchange between theoretical discourses, my practice, and audience response. The theoretical discourse includes a survey of the notions of time from different fields of knowledge from science, literature, anthropology, and memory studies. Additionally, an analysis of two contemporary installations, Normal & Nature by a Thai artist, Kamin Lertchaiprasert, and Going Forth by Day by an American artist, Bill Viola, is included.
Project 1, A solo show by Toeingam Srisubut, featured three art pieces: time-scape, container site, and ... and a real TV. The first project explored the potential media that can give shape to time and make the characteristics of time explicit. My evaluation of this project focuses on analysing the characteristics of time that grow out of my three works, and examining the audience's multiple readings of time that reveal various indicators, e.g. spaces, narratives, audience's and my memories, and certain Thai social and economic elements.
In Project 2, a sound and performance installation Rush Hour, narrative, space, and audience participation are considered specifically. I am testing out how effective the three indicators can give shape to time, and identifying the different characteristics of time of the installation placed in a specific environment of Koh Samui.
Project 3, a mix-media installation, When I grow rich, say the bells of Shoreditch, re-tested the three indicators. This project demonstrates my personal, cultural engagements and interpretations of these indicators. The research identifies further areas for potential studies within various aspects of time as well as practical ways of giving shape to it
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