1,722,804 research outputs found
Onward and upward
No full textAuthor Affiliations
Past and Current Editors-in-Chief, Human Reproduction Update
As Human Reproduction Update changes its Editor-in-Chief with the first issue of 2013, it is an apt time to reflect on the history of this journal and project plans for a strong future
Plasma gonadotropin releasing hormone and corticotropin releasing hormone levels in pathological pregnancies
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Review: Human reproduction in art: from myths to hystory
No full textConception, gestation, and birth, including maternalĝ€" fetal health, have been the subject of narrative and art since early human history. Myth and histories related to pregnancy were represented by sculptors and painters as well as the subject of several operas: the mystery of reproduction was always a fascinating theme. This mystery was commonly represented across cultures and time, in the old world, from Egypt to India, to Greece and Rome continuing until the Renaissance and the Modern period. To be an artist meant also to be a scientist in several societies. The current paper reports 12 examples of the fusion of art and reproductive science. © The Author(s) 2010
Human placental corticotropin-releasing factor (CRF) in the adaptive response to pregnancy
No full textSeveral findings suggest a role of placental hormones in the regulation of maternal and fetal physiology during pregnancy. The placenta and its accessory membranes, amnion and chorion, although of fetal origin, actually undertake the role of intermediary barriers and active messengers in the maternal-fetal dialogue. They synthesize, metabolize and serve as targets for numerous hormones and cytokines which control all aspects of pregnancy and parturition. Among these, corticotropin-releasing factor (CRF) has been one of the most investigated in the last decade. The secretion of placental CRF is autonomous, but increasing evidence indicates that maternal or fetal physiological and pathological conditions may influence such secretion. In the event of acute or chronic metabolic, physical or infection stress, the placenta takes part in a stress syndrome by releasing CRF, which may contribute to restore local blood flow, and to influence the timing of delivery. Placental CRF and cytokines produced in case of intrauterine infection may activate labour, thereby helping the fetus to escape from a hostile environment.On the background of maternal and/or fetal stress elicited by a number of pathological conditions, CRF appears to play a role in coordinating adaptive changes in uterine perfusion,maternal metabolism, fluid balance and possibly uterine contractility
Opioid control of luteinizing hormone secretion in humans.
No full textThe observation that heroin-addicted subjects are amenorrheic and/or hypogonadic suggested a possible role of endogenous opioid peptides (EOP) in the regulation of the hypothalamus-pituitary-gonodal axis. Because EOP are localized all through the axis, they may influence the reproductive function acting at various levels. The injection of morphine decreases plasma LH levels, abolishing the pulsatile pattern of secretion. The evidence that naloxone, an opiate receptor blockade, increases LH levels suggests a tonic inhibitory action of EOP. The naloxone-induced LH increase is not observed before pubertal maturation, in both sexes, and is absent in children with delayed or precocious puberty and in those with Klinefelter's or Turner's syndrome, suggesting a role of gonadal function on the opioid control of LH secretion. In adult women this LH response to naloxone is present during the periovulatory and the luteal phase of the menstrual cycle, suggesting a permissive role of estradiol and mainly of progesterone on the action of EOP on the LH secretion. Indeed, in amenorrheic subjects naloxone lacks to stimulate plasma LH levels and the treatment for the induction of ovulation restores this activity. An increased inhibitory action of EOP on GnRH release may explain the inefficacy of naloxone to stimulate LH secretion in hypogonadotropinic patients, while a decreased action has been hypothesized in postmenopausal women. The clinical implications of EOP in reproductive medicine appear to be promising
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