3,802 research outputs found
Genetic analyses and new models to improve therapeutic strategies in pancreatic cancer
Full text linkPeters, G.J. [Promotor]Giovannetti, E. [Copromotor]Würdinger, T. [Copromotor]Schuurhuis, G.J. [Copromotor
New avenues in pancreatic cancer: Targeting epigenetics and metabolism
Full text linkPeters, G.J. [Promotor]Giovannetti, E. [Copromotor
Mechanisms of trifluorothymidine cytotoxicity and thymidine phosphorylase induced angiogenesis
Full text linkPeters, G.J. [Promotor]Kruyt, F.A.E. [Copromotor
Pathogenesis of neurotoxicity and role of signaling in the efficacy of anticancer agents
Full text linkPeters, G.J. [Promotor]Giovannetti, E. [Copromotor
Molecular aspects of 5-Fluorouracil and Oxaliplatin activity
Full text linkPeters, G.J. [Promotor]Groeningen, C.J. van [Copromotor
Tumor cell resistance to antiangiogenic receptor tyrosine kinase inhibitors
Full text linkVerheul, H.M.W. [Promotor]Peters, G.J. [Promotor
Determinants of antifolate and 5-fluorouracil efficacy
Full text linkPeters, G.J. [Promotor]Pinedo, H.M. [Promotor]Jansen, G. [Copromotor
Fluid phase behaviour of ionic liquid-based systems of interest for green processes: Measurements and modelling
No full textIn the last decades a large number of applications with ionic liquids (IL) have emerged, and since the discovery that carbon dioxide can tune the miscibility of IL+organic mixtures, special attention has been drawn to the use of IL and CO2 as combined solvents for synthesis and extractions. To evaluate the applicability of the miscibility switch in different systems, this thesis presents the investigation of phase diagrams of ternary systems based on the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate (bmim[BF4]), carbon dioxide and different organic solutes. Four reactions of interest of the pharmaceutical and fine chemical industry, among them three hydrogenations, were selected as model reactions to provide the organic solutes used in phase behaviour measurements. Experiments were carried out in the Cailletet apparatus with CO2 composition varying from 10 mol% up to 70 mol%. For measurements performed with CO2 compositions up to 50 mol% and under the experimental conditions of this work, mostly liquid-vapour phase boundaries were found. For CO2 compositions above 50 mol%, the complexity of the phase diagrams increased significantly and not only liquid-vapour but also liquid-liquid phase transitions were found, as well as a very narrow three-phase region L1L2V was detected. The effect of CO2 composition in the location and extension of the homogeneous liquid phase has been also investigated. Additionally to experimental data collection, the potential of using the Group Contribution Equation of State for modelling the phase diagrams obtained in this work has been studied. Very good agreement has been found for L+V->L as well as L1+L2->L phase transitions. According to the results presented in this thesis, the GC-EOS can be considered suitable for prediction of phase equilibria in ternary systems based on an ionic liquid and carbon dioxide.Mechanical Maritime and Materials Engineerin
Combined reactions and separations using ionic liquids and carbon dioxide
No full textA new and general type of process for the chemical industry is presented using ionic liquids and supercritical carbon dioxide as combined reaction and separation media. In this process, the carbon dioxide pressure controls the miscibility of reactants, products, catalyst and ionic liquid, enabling fast atom-efficient reactions in a homogenous phase as well as instantaneous product recovery in a biphasic system. High reaction and separation rates can be achieved compared with the conventional fully biphasic alternative. Experimental and theoretical methods are used to find the operating conditions of the new approach. When the ionic liquid/carbon dioxide process is applied to the production of 1600 ton/year Levodopa, a medicine against Parkinsonian disease, the energy consumption is reduced with 20,000 GJ per year and the waste generation is reduced with 4800 ton of methanol per year and 480 kg catalyst per year, resulting in a decrease in total operational costs of 11.3 million euros per year. Therefore, from an economical and an environmental point of view, fast implementation of the new process-set up is desired. Suggestions for the fastest implementation are made based on the cyclic innovation model.Applied Science
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