3,346 research outputs found
Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time
No full textLive cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses.Christie A. Bader, Alexandra Sorvina, Peter V. Simpson, Phillip J. Wright, Stefano Stagni, Sally E. Plush, Massimiliano Massi and Douglas A. Brook
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
Introduction to the special issue
No full textDr Zach Simpson and Prof Peter Looker, the editors of this second, special issue of SOTL in the South, contextualise the papers in the issue in relationship to one another. These articles were select for double-blind peer-review and publication after being presented at the SOTL in the South conference in July 2017 in Johannesburg, South Africa.
How to cite this editorial:
SIMPSON, Zach; LOOKER, Peter. Editorial: introduction to the special issue. Scholarship of Teaching and Learning in the South. v. 2, n. 1, p. 1-3, Apr. 2018. Available at: http://sotl-south-journal.net/?journal=sotls&page=article&op=view&path%5B%5D=52
This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
 
The People v. Orenthal James Simpson: Race and Trial Advocacy
No full textThis chapter focuses on the trial story behind the high profile case of People v. Orenthal James Simpson. As the author points out, the Simpson case focused attention on some of the most important issues in the criminal justice system, including class and race disparities, DNA evidence, and police perjury. The author here focuses on the issue of race--its significance in the trial and how it affected the advocacy of the lawyers. She discusses the emotional conflicts over race within the defense and prosecution teams and compares and contrasts the approaches that each side ultimately decided to take. The author examines how race affected the choice of lawyers, venue and jury selection, the direct and cross-examination of the trials most controversial witness, and the closing arguments. She suggests that the strategic decisions about race made by both sides may have largely determined the outcome of the case.https://digitalcommons.wcl.american.edu/facsch_bk_contributions/1099/thumbnail.jp
Brief Investigatory Detentions: A Critique of R. v. Simpson
No full textIn this article, the author examines the brief investigative detention power created by the Ontario Court of Appeal in R. v. Simpson and challenges both the Court\u27s reasoning and the way in which the decision has been followed in other Canadian jurisdictions. The common law power to detain an individual, based upon prominent U.S. and British case law, is inconsistent with the previous Supreme Court jurisprudence on police powers. The author demonstrates this by analyzing several cases involving police powers and joins the list of commentators who have urged the country\u27s highest court to re-examine the Simpson doctrine. The author also argues that there has been a tendency for U.S. courts to grant increased discretion to the police even when such powers are unwarranted. There is a real possibility of a similar accretion of police powers in Canada. Moreover, the American experience also indicates that members of minority groups are frequently subjected to the rigours of brief investigative detention, often only because of their ethnic identity. Recent studies show that the same trend exists in Canada, serving to challenge democratic and egalitarian values that the Charter is designed to protect. The solution, according to the author, lies not with the Courts, but with Parliament taking the opportunity to define the extent and limits of brief investigative detentions
Biblical Money and the Church\u27s Mission in the Digital Age
No full textThis article examines the relationship between biblical money principles and the mission of the church in the digital age, focusing on Bitcoin as a form of "biblical money" that transcends the modern fiat money system. Based on Luke 16:9 and teachings such as Leviticus 19:36 and Proverbs 11:1, the author asserts that fair money should reflect honesty, avoid value-stealing inflation, and reduce dependence on debt. Bitcoin is judged to meet the principles of scarcity, fragmentability, portability, and resistance to censorship, making it most in line with biblical values of economic justice. In the Indonesian context, although still limited in regulation, Bitcoin has the potential to be used for the storage of value, funding cross-cultural missions, and empowering churches through decentralized financial technology. This article invites the church to rethink missiological finance by applying biblical money ethics in the midst of global economic challenges
A molecular probe for the detection of polar lipids in live cells
No full textData source: Supporting Information, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161557#sec017Lipids have an important role in many aspects of cell biology, including membrane architecture/compartment formation, intracellular traffic, signalling, hormone regulation, inflammation, energy storage and metabolism. Lipid biology is therefore integrally involved in major human diseases, including metabolic disorders, neurodegenerative diseases, obesity, heart disease, immune disorders and cancers, which commonly display altered lipid transport and metabolism. However, the investigation of these important cellular processes has been limited by the availability of specific tools to visualise lipids in live cells. Here we describe the potential for ReZolve-L1™ to localise to intracellular compartments containing polar lipids, such as for example sphingomyelin and phosphatidylethanolamine. In live Drosophila fat body tissue from third instar larvae, ReZolve-L1™ interacted mainly with lipid droplets, including the core region of these organelles. The presence of polar lipids in the core of these lipid droplets was confirmed by Raman mapping and while this was consistent with the distribution of ReZolve-L1™ it did not exclude that the molecular probe might be detecting other lipid species. In response to complete starvation conditions, ReZolve-L1™ was detected mainly in Atg8-GFP autophagic compartments, and showed reduced staining in the lipid droplets of fat body cells. The induction of autophagy by Tor inhibition also increased ReZolve-L1™ detection in autophagic compartments, whereas Atg9 knock down impaired autophagosome formation and altered the distribution of ReZolve-L1™. Finally, during Drosophila metamorphosis fat body tissues showed increased ReZolve-L1™ staining in autophagic compartments at two hours post puparium formation, when compared to earlier developmental time points. We concluded that ReZolve-L1™ is a new live cell imaging tool, which can be used as an imaging reagent for the detection of polar lipids in different intracellular compartments.Christie A. Bader, Tetyana Shandala, Elizabeth A. Carter, Angela Ivask, Taryn Guinan, Shane M. Hickey, Melissa V. Werrett, Phillip J. Wright, Peter V. Simpson, Stefano Stagni, Nicolas H. Voelcker, Peter A. Lay, Massimiliano Massi, Sally E. Plush, Douglas A. Brook
Kanter Revisited: Gender, Power and (In)visibility
No full textThis paper revisits Kanter's (1977) seminal work Men and Women of the Corporation, rereading her account of numerical advantage and disadvantage through a poststructuralist lens which exposes hidden dimensions of gendered power. This lens is captured in the ‘(In)visibility Vortex’ (Lewis and Simpson, 2010) which highlights struggles and tensions around the norm through processes of preservation and concealment within the norm as well as dynamics of revealing, exposure and disappearance as features of the margins. The study draws on developments in feminist theorizing, specially around visibility, invisibility and power, to facilitate this rereading. In so doing, the author demonstrate that while Kanter retreated from explanations based on the gendering of organizations or from recognition of gendered power, these dynamics can be identified in her text. The authors suggest that rereading classic texts can surface dimensions of organizations that have contemporary significance and can inform future research
Uranium: mineralogy, geochemistry, and the environment Reviews in mineralogy ;, v. 38./ editors, Peter C. Burns & Robert J. Finch.
No full textIn English.Includes bibliographical references.Volume 38 of Reviews in Mineralogy provides detailed reviews of various aspects of the mineralogy and geochemistry of uranium. We have attempted to produce a volume that incorporates most important aspects of uranium in natural systems, while providing some insight into important applications of uranium mineralogy and geochemistry to environmental problems. The result is a blend of perspectives and themes: historical (Chapter 1), crystal structures (Chapter 2), systematic mineralogy and paragenesis (Chapters 3 and 7), the genesis of uranium ore deposits (Chapters 4 and 6), the geochemical behavior of uranium and other actinides in natural fluids (Chapter 5), environmental aspects of uranium such as microbial effects, groundwater contamination and disposal of nuclear waste (Chapters 8, 9 and 10), and various analytical techniques applied to uranium-bearing phases (Chapters 11-14).This volume was written in preparation for a short course by the same title, sponsored by the Mineralogical Society of America, October 22 and 23, 1999 in Golden, Colorado, prior to MSA's joint annual meeting with the Geological Society of America.Ewing, Rodney C. -- Burns, Peter C. -- Finch, Robert / Murakami, Takashi -- Fayek, Mostafa / Kyser, T. Kurtis -- Murphy, William M. / Shock, Everett L. -- Plant, Jane A. / Simpson, Peter R. / Smith, Barry / Windley, Brian F. -- Janeczek, Janusz -- Suzuki, Yohey / Banfield, Jillian F. -- Abdelouas, Abdesselam / Lutze, Werner / Nuttall, H. Eric -- Wronkiewicz, David J. / Buck, Edgar C. -- Hanchar, John M. -- Čejka, Jiři -- Wolf, Stephen F. -- Hill, Frances C. Frontmatter -- COPYRIGHT -- ADDITIONAL COPIES -- FOREWORD -- PREFACE -- Mineralogy, Geochemistry and the Environment -- TABLE OF CONTENTS -- 1. Radioactivity and the 20th Century / 2. The Crystal Chemistry of Uranium / 3. Systematics and Paragenesis of Uranium Minerals / 4. Stable Isotope Geochemistry of Uranium Deposits / 5. Environmental Aqueous Geochemistry of Actinides / 6. Uranium Ore Deposits- Products of the Radioactive Earth / 7. Mineralogy and Geochemistry of Natural Fission Reactors in Gabon / 8. Geomicrobiology of Uranium / 9. Uranium Contamination in the Subsurface: Characterization and Remediation / 10. Uranium Mineralogy and the Geologic Disposal of Spent Nuclear Fuel / 11. Spectroscopic Techniques Applied to Uranium in Minerals / 12. Infrared Spectroscopy and Thermal Analysis of the Uranyl Minerals / 13. Analytical Methods for Determination of Uranium in Geological and Environmental Materials / 14. Identification of Selected Uranium-bearing Minerals and Inorganic Phases by X-ray Powder Diffraction /1 online resource (695 p.)
John A. Simpson
No full textJohn A. Simpson
Inducted: 1999
Citation: For metrological research and for creativity and innovation in developing a unique computer-controlled research facility for studying fully automated manufacturing.
Tenure: 1948-1993
Birth: 1923, Toronto, Canada
Death: 2011
Education:
Lehigh University, degrees in physics: BS, 1946; MS, 1948; PhD, 1953
Positions held:
Physicist, Supervisory Physicist and Chief, Electron Physics Section, Atomic Physics Division
Chief, Electron Physics Section, Atomic and Molecular Physics Division
Deputy Chief, Optical Physics Division
Acting Chief, Mechanics Division
Director, Center for Manufacturing Engineering, Center for Mechanical Engineering and Process Technology
Director, Manufacturing Engineering Laboratory
Honors:
U. S. Department of Commerce Gold Medal, 1975
NBS Applied Research Award, 1980
NBS Allen V. Astin Measurement Science Award, 1984
Senior Executive Service, Distinguished Executive Award, 1985
American Machinist Award, 1986
Elected to Sigma Xi
Memberships:
American Physical Society (Fellow)
National Academy of Sciences/National Research Council
National Academy of Engineering
Publications:
Author of many scientific and technical publications
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